Chary 1984

Referenz

(Autor, Jahr, Journal)

Studientyp

Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum

Patientenmerkmale

Indikation, Alter, Geschlecht (m/w), CTX

Intervention

Kontrolle

Zielgröße

Primary Endpoint

Secondary Endpoint

Finanzierung

Evidenzstufe (CEBM levels/ SIGN)

Bei Abwertung: Angabe von Gründen

Chary 1984

Int. j. Radiation Oncology Biol. Phys.

Monocenter

Randomized, double-blind study

Two arms

N= 33

Canada

Cervix and prostate cancer

67.9±7.1 vs. 68.1±6. yrs.

m/f

Radiation mean dosis: 49.60±1.8 Gy

N= 17

Low fat diet (40 g/d) + 4 g cholestyramine twice daily after the second week

N= 16

Low fat diet (40 g/d) 4 g placebo twice daily

Diarrhea Incidence

Diarrhea Incidence (1/17 vs. 6/16)

Good compliance in both groups

Nausea/Emesis (6/17 vs. 2/16)

Abdominal cramping (6/17 vs. 2/16)

Dr. J.E. Knapp, Bristol-Myers Pharmaceutical group supplied the mediacation

2b/1-

Small sample size

“Cholestyramin is effective in preventing acute diarrhea induced by pelvic irradiation in patients receiving a low fat diet but is associated with side effects.”