Cao_2017

Referenz

(Autor, Jahr, Journal)

Studientyp

Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum

Patienten-merkmale

Indikation, Alter, Geschlecht (m/w)

Intervention

Fallzahl n, Beschreibung der präventiven bzw. therapeutischen Maßnahme

Kontrolle

Fallzahl n, Beschreibung der präventiven Maßnahme bzw. therapeutischen Maßnahme

Zielgrößen

Primärer Endpunkt

Sekundäre(r) Endpunkt(e)

Primärer Endpunkt

Angaben für Intervention vs. Kontrolle

Sekundäre(r) Endpunkt(e)

Angaben für Intervention vs. Kontrolle

Finanzierung

Evidenzstufe

Bei Abwertung: Angabe von Gründen

Bewertung des Autors

Cao

2017

Oncotarget

Kozelsky, 2003

Yang, 2004

Zhou, 2007

Rao, 2009

Qi, 2011

Wu, 2011

Zhang, 2012

Gu, 2012

Zhao, 2013

Vidal-Casariego, 2014

Meng, 2014

Chi, 2015

Chen, 2015

meta-analysis

n = 13 RCTs

n = 979 pts

China

1990 and 2016

cancer patients with radiation enteritis after receiving pelvic and/or abdominal

radiotherapy

Age: 30-78

glutamine for curing acute radiation enteritis: 9 RCTs

glutamine for chronic radiation enteritis: 4 RCTs

glutamine

placebo

primary endpoint: overall response rate

secondary endpoint: symptom score

N = 7  RCTs

efficacy of glutamine in improving radiation enteritis: 3.07 (95%CI: 0.79-11.96; P>0.05)

Severity of radiation enteritis

OR (95%CI)

Grade 0: 2,06 (0,82, 5,19)

Grade 1: 1,35 (0,84, 2,17)

Grade 2: 0,55 (0,20 ,1,46)

Grade 3: 0,62 (0,37, 1,02)

Grade 4: 0,59 (0,13, 2,64)

(P > 0.05 for all).

Tenesmus

grade 0: 1.14 (95%CI: 0.34-3.77)

grade 1: 0.92 (95%CI: 0.49-1.74)

grade 2: 1.38 (95%CI: 0.24-

8.03)

grade 3: 1.02 (95%CI: 0.14-7.44)

(P>0.05).

Abdominal cramping

grade 0: 1,38 (95%CI:0,21-9,12)

grade 1:1,05 (95%CI:0,39-2,84)

grade 2: 0,58 (95%CI:0,18-1,81)

grade 3: 1,24 (95%CI:0,36-4,29)

Blood in bowel movement

None: 1.50 (95%CI: 0.40-5.65)

Mild: 0.96 (95%CI: 0.51-1.82)

Moderate: 0.46 (95%CI:0.19-1.11)

(P>0.05 for all).

The authors declared that there were no competing interests related to this study.

1

no significant heterogeneity among included trials
some of the included studies were low quality
no information about the randomization methods, blinding, allocation
concealment

insufficient available data

"Implementation of glutamine fails to improve the severity and symptoms in patients with radiation enteritis."