Salminen 1988

Referenz

(Autor, Jahr, Journal)

Studientyp

Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum

Patientenmerkmale

Indikation, Alter, Geschlecht (m/w), CTX

Intervention

Kontrolle

Zielgröße

Primary Endpoint

Secondary Endpoint

Finanzierung

Evidenzstufe (CEBM levels/ SIGN)

Bei Abwertung: Angabe von Gründen

Salminen 1988

Clinical Radiology

Monocenter

Randomized study

Two arms

N= 24

Finnland

Cervix and uterus carcinoma

40-75 yrs.

female

Postoperative radiation therapy

N= 11

Dietary counselling (fat-free diet, low-residue diet) and 150 ml fermented milk test product  2x10⁹ live Lactobacillus acidophilus bacteria and 6,5% lactulose

One per day, 5 days prior to RT, throughout RT and for ten days after finishing the treatment regimen

N= 10

Dietary counselling (fat-free diet, low-residue diet)

Incidence of diarrhea at different control times: before treatment (1), during the treatment (2, 3, 4), six weeks after the treatment (5)

Incidence of diarrhea

control time 1 (0/11 vs. 0/10)

control time 2 (3/11 vs. 8/10) (p<0.01)

control time 3 (2/11 vs. 9/10) (p<0.01)

control time 4 (2/11 vs. 8/10) (p<0.01)

control time 5 (3/11 vs. 9/10) (p<0.01)

Use of antidiarrhoeal drugs (1/11 vs. 6/10) (p<0.01)

Test Group tolerated the yoghurt treatment well.

No information

2b-/1-

Small sample size, no blinding, no placebo was given

“The results indicated that the test product appeared to prevent radiotherapy-associated diarrhea.”