An 2021

Referenz

(Autor, Jahr, Journal)

Studientyp

Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum

Patienten-merkmale

Indikation, Alter, Geschlecht (m/w)

Intervention

Fallzahl n, Beschreibung der präventiven bzw. therapeutischen Maßnahme

Kontrolle

Fallzahl n, Beschreibung der präventiven Maßnahme bzw. therapeutischen Maßnahme

Zielgrößen

Primärer Endpunkt

Sekundäre(r) Endpunkt(e)

Primärer Endpunkt

Angaben für Intervention vs. Kontrolle

Sekundäre(r) Endpunkt(e)

Angaben für Intervention vs. Kontrolle

Finanzierung

Evidenzstufe

Bei Abwertung: Angabe von Gründen

Bewertung des Autors

An

2021

Food Funct.

meta-analysis of randomized controlled trials

n = 715

China

until July 2020

Age: 18–89 y

Tumor: nasopharynx and larynx, paranasal sinus, thyroid, oral cavity, oropharynx,

hypopharynx, and parotid and mastoid areas.

radiotherapy dose: 50–70 Gy

9/11 studies: 60–70 Gy.

honey vs. controls (placebo, alternative medicine, or no preventive intervention)

Honey: Ziziphus honey, manuka honey, thyme honey, and natural honey

1 trial: honey + 0.15% benzydamine hydrochloride.

control group: normal saline, salt–soda, gargle, placebo, betadine, or lignocaine gel.

application:

20 mL of honey or control agent swallowed slowly 15 min before and after radiotherapy

2 studies (20 mL of honey diluted in 100 mL of purified

water).

primary outcome: number of mucositis incidences

secondary outcomes: Weight loss, pain scale, incidence of severe pain

Honey significantly reduced the incidence of grade 2 (OR: 0.43, 95%CI: 0.54–0.98, P = 0.03), grade 3 (OR: 0.24, 95% CI:0.16–0.35, P < 0.001) and grade 4 mucositis (OR: 0.17, 95%CI: 0.08–0.36, P < 0.001).

grade 1 (OR: 1.54, 95%CI: 1.15–2.06, P = 0.003): honey was not significant in preventing radiation-induced mucositis.

The incidence of unbearable pain was lower in the honey group at all grades (OR: −0.20, 95%CI: −0.33 to−0.07).

The effect of honey on weight loss and pain score was not statistically significant

This work was supported by the National Natural Science

Foundation of China (No. 81570991)

1

limited sample size led to problems of reliability and heterogeneity

"Honey can prevent and alleviate grade 2–4 mucositis, especially in high grade mucositis. Honey also provides some relief from severe pain. But, more evidence is required to prove that honey is an effective substance for relieving pain or minimizing weight loss."