Froseth_2015
Supportive Therapie · Version 2.1
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Referenz (Autor, Jahr, Journal) |
Studientyp Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum
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Patienten-merkmale Indikation, Alter, Geschlecht (m/w) |
Intervention Fallzahl n, Beschreibung der präventiven bzw. therapeutischen Maßnahme |
Kontrolle Fallzahl n, Beschreibung der präventiven Maßnahme bzw. therapeutischen Maßnahme |
Zielgrößen Primärer Endpunkt Sekundäre(r) Endpunkt(e) |
Primärer Endpunkt Angaben für Intervention vs. Kontrolle Sekundäre(r) Endpunkt(e) Angaben für Intervention vs. Kontrolle |
Finanzierung |
Evidenzstufe Bei Abwertung: Angabe von Gründen Bewertung des Autors |
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Frøseth
2015
Radiation Oncology |
randomized study
2 centre
n = 91
2005 – 2008
Norway |
locally advanced rectal cancer
concomiant chemotherapy (5-fluorouracil or Capecitabine),
RT before surgery: 94%
male: 54 age median: 62y (32-81)
female: 29 age median: 63 (52-74)
BMI (kg/m2) Mean (SD) Supine: 26.5 (0.2), Range 17.2 – 36.3 Prone: 26.9 (0.3), Range 17.9 – 39.4
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N = 40
RT in prone position |
N = 43
RT in supine position |
mean vector length
Dose volume relations to organs at risk |
supine position vs. prone position
estimated mean vector length (95 % CI) from LMM analysis: 5.8 mm (5.1–6.6 mm) vs. 7.1 mm (6.3–8.1 mm)
(p = 0.024).
Dose volume relations to organs at risk Mean dose ± SD (Gy), Range (Gy)
Small bowel 6.0 ± 5.2 (0.6 - 20.0) vs. 5.8 ± 5.9 (0.4 – 23.2); p = 0.85 total bowel 4.8 ± 3.4 (0.3 – 13.9) vs. 5.8 ± 4.5 (1.1 – 18.9); P =0.29 Bladder 32.6 ± 10.7 (7.1 – 47.3) vs. 33.5 ± 11.7 (6.9 – 46.3); p=0.74 |
The research was funded by grants from the Central Norway Regional Health Authority, St. Olavs University Hospital and Sør-Trøndelag University College. The authors owe the particular thanks to the participating patients and the staff at the departments of radiotherapy at St. Olavs University Hospital and Ålesund Hospital |
2b measurements of setup errors were made in only 43 % of the fractions, which may represent a sampling bias block randomisation
"The patient positioning in RT of rectal cancer patients may therefore be decided based on other factors such as the most comfortable position for the patients." |