Tungkasamit 2022
Supportive Therapie · Version 2.1
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Referenz (Autor, Jahr, Journal) |
Studientyp Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum |
Patienten-merkmale Indikation, Alter, Geschlecht (m/w) |
Intervention Fallzahl n, Beschreibung der präventiven bzw. therapeutischen Maßnahme |
Kontrolle Fallzahl n, Beschreibung der präventiven Maßnahme bzw. therapeutischen Maßnahme |
Zielgrößen Primärer Endpunkt Sekundäre(r) Endpunkt(e) |
Primärer Endpunkt Angaben für Intervention vs. Kontrolle |
Sekundäre(r) Endpunkt(e) Angaben für Intervention vs. Kontrolle |
Finanzierung |
Evidenzstufe Bei Abwertung: Angabe von Gründen Bewertung des Autors |
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Tungkasamit et al. 2022
Eur J Oncol Nurs |
multicenter randomized double-blind controlled study
3 centre
Thailand
n = 120 |
HNC patients treated with concurrent chemoradiation (CCRT)
Study group (n =60) Male n = 47 (78.3%)
Age 53,5 (33–71)
Control group (n =60) Male: n = 48 (80.0%)
Age: 57 33–83 |
Study group (n =60)
87.4% of aloe vera in hydrophilic gel |
Control group (n =60)
placebo |
efficacy of topical aloe vera gel on radiation induced dermatitis (RID) in head and neck cancer (HNC)
radiation-induced skin reaction assessment scale (RISRAS) |
Skin erythema study vs. control group Week 5 moderate/severe grade: 8 (13.6) vs. 15 (27.8); p-value 0.050
week 6 moderate/severe grade: 14 (24.1) vs. 23 (42.6); p-value 0.038
week 8 moderate/severe grade: 7 (38.9) vs. 4 (36.4); p-value 0.604
Burning sensation Week 7 RISRAS 3-4: 0 vs. 5 (11.9); p=0.016 |
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2 variations associated with radiotherapy techniques several patient factors may have affected the severity of RID
"Topical applications of aloe vera gel significantly reduced moderate to severe grades of skin erythematous and instances of moist desquamation in HNC patients receiving CCRT. In this study, there was no prophylactic efficacy for RID in the aloe vera gel group when compared to the placebo group."
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