Huang_2020
Supportive Therapie · Version 2.1
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Referenz (Autor, Jahr, Journal) |
Studientyp Mono- vs. Multizentrisch, Verblindung, Randomisierung, Arme, Fallzahl n, Land, Zeitraum
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Patienten-merkmale Indikation, Alter, Geschlecht (m/w) |
Intervention Fallzahl n, Beschreibung der präventiven bzw. therapeutischen Maßnahme |
Kontrolle Fallzahl n, Beschreibung der präventiven Maßnahme bzw. therapeutischen Maßnahme |
Zielgrößen Primärer Endpunkt Sekundäre(r) Endpunkt(e) |
Primärer Endpunkt Angaben für Intervention vs. Kontrolle Sekundäre(r) Endpunkt(e) Angaben für Intervention vs. Kontrolle |
Finanzierung |
Evidenzstufe Bei Abwertung: Angabe von Gründen Bewertung des Autors |
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Huang
2020
BMC Surg |
retrospective
Single centre
N = 811
China
11/2011 – 02/2019 |
Radiation-induced enteritis (RE) after pelvic malignancy radiation
N = 284 (35%) patients with rectal ulcer
N = 61 eligible for this study
mean age: 56.5±10.4 year
median interval between radiotherapy and colostomy: 11.8 months (interquartile ratio 8.7–16.1).
primary malignancies: cervical cancer (n=56), prostatic cancer (n=2), endometrial cancer (n=2) and rectal cancer (n=1)
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diverting colostomy on rectal ulcer of CRP patients
Pre-colostomy vs. Post-colostomy
Effective (n=30) vs. Ineffective (n=31) |
effect of colostomy on ulcerative CRP
influence factors with effectiveness of colostomy. |
overall effective rate of colostomy on ulcerative CRP: 49.2% (30/61)
CRP patients with ulcers cured after colostomy: 9 (31.1%)
pts restored intestinal continuity: 12 (19.67%)
remarkably alleviated pts with rectal bleeding: 100% (55/55) pts with anal pain: 91.4% (32/35)
multivariable analysis - independent influence factors for the effectiveness of colostomy on the rectal ulcer of CRP patients duration of stoma [OR1.211, 95% CI (1.060–1.382), P=0.005] albumin (ALB) level post-colostomy [OR1.437, 95% CI (1.102–1.875), P=0.007] |
This study was supported by Sun Yat-sen University Clinical Research 5010 Program (Grant Number: 2019021), and the National Natural Science Foundation of China (Grant Number: 81573078). The above funders had no further role in the study design; collection, analysis and interpretation of data; writing of the manuscript; or the decision to submit this manuscript for publication. |
4 retrospective design and small sample size
"Colostomy was an efective and safe procedure for treating rectal ulcer of CRP patients, and also a potential strategy for preventing and treating fstula. Duration of stoma for 12–24 months and higher ALB level could significantly improve the effectiveness of colostomy on ulcerative CRP patients." |
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