Leitlinienprogramm OnkologieMundhöhlenkarzinom

14. Literaturverzeichnis – Mundhöhlenkarzinom

Version 3.0 · März 2021 · AWMF 007/100OL
Leitlinienprogramm Onkologie · Deutsche Krebsgesellschaft · Deutsche Krebshilfe · AWMF

1. Lippman, S. M., Spitz, M., Trizna, Z., Benner, S. E., Hong, W. K., Epidemiology, biology, and chemoprevention of aerodigestive cancer, Cancer, 1994. 74(9 Suppl): p. 2719-25.

2. Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (GEKID) in Zusammenarbeit mit dem Robert Koch Institut: 5. überarbeitete, aktualisierte Ausgabe, Saarbrücken 2006.

3. Lo, W. L., Kao, S. Y., Chi, L. Y., Wong, Y. K., Chang, R. C., Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival, J Oral Maxillofac Surg, 2003. 61(7): p. 751-8.

4. Howaldt, H. P., Vorast, H., Blecher, J. C., Reicherts, M., Kainz, M., Ergebnisse aus dem DÖSAK Tumorregister, Mund-, Kiefer- und Gesichtschirurgie, 2000. 4 Suppl 1: p. S216-25.

5. Talamini, R., Bosetti, C., La Vecchia, C., Dal Maso, L., Levi, F., Bidoli, E., et.al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study, Cancer Causes Control, 2002. 13(10): p. 957-64.

6. La Vecchia, C., Tavani, A., Franceschi, S., Levi, F., Corrao, G., Negri, E., Epidemiology and prevention of oral cancer, Oral Oncol, 1997. 33(5): p. 302-12.

7. Figuero Ruiz, E., Carretero Pelaez, M. A., Cerero Lapiedra, R., Esparza Gomez, G., Moreno Lopez, L. A., Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer, Med Oral, 2004. 9(1): p. 14-23.

8. Horowitz, A. M., Canto, M. T., Child, W. L., Maryland adults' perspectives on oral cancer prevention and early detection, J Am Dent Assoc, 2002. 133(8): p. 1058-63.

9. Warnakulasuriya, K. A., Harris, C. K., Scarrott, D. M., Watt, R., Gelbier, S., Peters, T. J., et.al. An alarming lack of public awareness towards oral cancer, Br Dent J, 1999. 187(6): p. 319-22.

10. Vora, A. R., Yeoman, C. M., Hayter, J. P., Alcohol, tobacco and paan use and understanding of oral cancer risk among Asian males in Leicester, Br Dent J, 2000. 188(8): p. 444-51.

11. Cruz, G. D., Le Geros, R. Z., Ostroff, J. S., Hay, J. L., Kenigsberg, H., Franklin, D. M., Oral cancer knowledge, risk factors and characteristics of subjects in a large oral cancer screening program, J Am Dent Assoc, 2002. 133(8): p. 1064-71; quiz 1094.

12. Hay, J. L., Ostroff, J. S., Cruz, G. D., LeGeros, R. Z., Kenigsberg, H., Franklin, D. M., Oral cancer risk perception among participants in an oral cancer screening program, Cancer Epidemiol Biomarkers Prev, 2002. 11(2): p. 155-8.

13. Scottish Intercollegiate Guidelines Network, SIGN 90: Diagnosis and management of head and neck cancer, 2006.

14. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften - Ständige Kommission Leitlinien, AWMF-Regelwerk "Leitlinien", 1. Auflage 2012. 2013:

15. Altieri, A., Bosetti, C., Talamini, R., Gallus, S., Franceschi, S., Levi, F., et.al. Cessation of smoking and drinking and the risk of laryngeal cancer, Br J Cancer, 2002. 87(11): p. 1227-9.

16. Balaram, P., Sridhar, H., Rajkumar, T., Vaccarella, S., Herrero, R., Nandakumar, A., et.al. Oral cancer in southern India: the influence of smoking, drinking, paan-chewing and oral hygiene, Int J Cancer, 2002. 98(3): p. 440-5.

17. Cheng, Y. J., Hildesheim, A., Hsu, M. M., Chen, I. H., Brinton, L. A., Levine, P. H., et.al. Cigarette smoking, alcohol consumption and risk of nasopharyngeal carcinoma in Taiwan, Cancer Causes Control, 1999. 10(3): p. 201-7.

18. De Boer, M. F., Van den Borne, B., Pruyn, J. F., Ryckman, R. M., Volovics, L., Knegt, P. P., et.al. Psychosocial and physical correlates of survival and recurrence in patients with head and neck carcinoma: results of a 6-year longitudinal study, Cancer, 1998. 83(12): p. 2567-79.

19. de Graeff, A., de Leeuw, J. R., Ros, W. J., Hordijk, G. J., Blijham, G. H., Winnubst, J. A., Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer, Eur J Cancer, 2001. 37(3): p. 332-9.

20. De Stefani, E., Boffetta, P., Oreggia, F., Mendilaharsu, M., Deneo-Pellegrini, H., Smoking patterns and cancer of the oral cavity and pharynx: a case-control study in Uruguay, Oral Oncol, 1998. 34(5): p. 340-6.

21. Franceschi, S., Levi, F., La Vecchia, C., Conti, E., Dal Maso, L., Barzan, L., et.al. Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer, Int J Cancer, 1999. 83(1): p. 1-4.

22. Lissowska, J., Pilarska, A., Pilarski, P., Samolczyk-Wanyura, D., Piekarczyk, J., Bardin-Mikollajczak, A., et.al. Smoking, alcohol, diet, dentition and sexual practices in the epidemiology of oral cancer in Poland, Eur J Cancer Prev, 2003. 12(1): p. 25-33.

23. Perea-Milla Lopez, E., Minarro-Del Moral, R. M., Martinez-Garcia, C., Zanetti, R., Rosso, S., Serrano, S., et.al. Lifestyles, environmental and phenotypic factors associated with lip cancer: a case-control study in southern Spain, Br J Cancer, 2003. 88(11): p. 1702-7.

24. Critchley, J. A., Unal, B., Health effects associated with smokeless tobacco: a systematic review, Thorax, 2003. 58(5): p. 435-43.

25. Bagnardi, V., Blangiardo, M., La Vecchia, C., Corrao, G., Alcohol consumption and the risk of cancer: a meta-analysis, Alcohol Res Health, 2001. 25(4): p. 263-70.

26. Corrao, G., Bagnardi, V., Zambon, A., Arico, S., Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis, Addiction, 1999. 94(10): p. 1551-73.

27. Talamini, R., Bosetti, C., La Vecchia, C., Dal Maso, L., Levi, F., Bidoli, E., et.al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study, Cancer Causes Control, 2002. 13(10): p. 957-64.

28. Corrao, G., Bagnardi, V., Zambon, A., Arico, S., Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis, Addiction, 1999. 94(10): p. 1551-73.

29. Perea-Milla Lopez, E., Minarro-Del Moral, R. M., Martinez-Garcia, C., Zanetti, R., Rosso, S., Serrano, S., et.al. Lifestyles, environmental and phenotypic factors associated with lip cancer: a case-control study in southern Spain, Br J Cancer, 2003. 88(11): p. 1702-7.

30. Critchley, J. A., Unal, B., Health effects associated with smokeless tobacco: a systematic review, Thorax, 2003. 58(5): p. 435-43.

31. Bosetti, C., Gallus, S., Trichopoulou, A., Talamini, R., Franceschi, S., Negri, E., et.al. Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract, Cancer Epidemiol Biomarkers Prev, 2003. 12(10): p. 1091-4.

32. Bosetti, C., Talamini, R., Levi, F., Negri, E., Franceschi, S., Airoldi, L., et.al. Fried foods: a risk factor for laryngeal cancer?, Br J Cancer, 2002. 87(11): p. 1230-3.

33. Levi, F., Pasche, C., Lucchini, F., Chatenoud, L., Jacobs, D. R., Jr., La Vecchia, C., Refined and whole grain cereals and the risk of oral, oesophageal and laryngeal cancer, Eur J Clin Nutr, 2000. 54(6): p. 487-9.

34. Oreggia, F., De Stefani, E., Boffetta, P., Brennan, P., Deneo-Pellegrini, H., Ronco, A. L., Meat, fat and risk of laryngeal cancer: a case-control study in Uruguay, Oral Oncol, 2001. 37(2): p. 141-5.

35. Bosetti, C., La Vecchia, C., Talamini, R., Negri, E., Levi, F., Fryzek, J., et.al. Energy, macronutrients and laryngeal cancer risk, Ann Oncol, 2003. 14(6): p. 907-12.

36. Uzcudun, A. E., Retolaza, I. R., Fernandez, P. B., Sanchez Hernandez, J. J., Grande, A. G., Garcia, A. G., et.al. Nutrition and pharyngeal cancer: results from a case-control study in Spain, Head Neck, 2002. 24(9): p. 830-40.

37. Franceschi, S., Favero, A., Conti, E., Talamini, R., Volpe, R., Negri, E., et.al. Food groups, oils and butter, and cancer of the oral cavity and pharynx, Br J Cancer, 1999. 80(3-4): p. 614-20.

38. De Stefani, E., Oreggia, F., Boffetta, P., Deneo-Pellegrini, H., Ronco, A., Mendilaharsu, M., Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay, Oral Oncol, 2000. 36(1): p. 47-53.

39. Bosetti, C., La Vecchia, C., Talamini, R., Negri, E., Levi, F., Dal Maso, L., et.al. Food groups and laryngeal cancer risk: a case-control study from Italy and Switzerland, Int J Cancer, 2002. 100(3): p. 355-60.

40. Tavani, A., Pelucchi, C., Parpinel, M., Negri, E., Franceschi, S., Levi, F., et.al. n-3 polyunsaturated fatty acid intake and cancer risk in Italy and Switzerland, Int J Cancer, 2003. 105(1): p. 113-6.

41. Cruz, G. D., Le Geros, R. Z., Ostroff, J. S., Hay, J. L., Kenigsberg, H., Franklin, D. M., Oral cancer knowledge, risk factors and characteristics of subjects in a large oral cancer screening program, J Am Dent Assoc, 2002. 133(8): p. 1064-71; quiz 1094.

42. Dahlstrom, K. R., Adler-Storthz, K., Etzel, C. J., Liu, Z., Dillon, L., El-Naggar, A. K., et.al. Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis, Clin Cancer Res, 2003. 9(7): p. 2620-6.

43. Herrero, R., Castellsague, X., Pawlita, M., Lissowska, J., Kee, F., Balaram, P., et.al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study, J Natl Cancer Inst, 2003. 95(23): p. 1772-83.

44. van der Waal, I., Scully, C., Oral cancer: comprehending the condition, causes, controversies, control and consequences. 6. Co-morbidities, Dent Update, 2011. 38(4): p. 283-4.

45. Axell, T., Hypersensitivity of the oral mucosa: clinics and pathology, Acta Odontol Scand, 2001. 59(5): p. 315-9.

46. Macfarlane, G. J., Boyle, P., Scully, C., Oral cancer in Scotland: changing incidence and mortality, BMJ, 1992. 305(6862): p. 1121-3.

47. Department of Dental Services. Screening for oral cancer., London: Royal College of Surgeons of England. 1994.

48. British Dental Association, Opportunistic oral cancer screening, BDA occasional paper, 2000. 6:

49. Elahi, A., Zheng, Z., Park, J., Eyring, K., McCaffrey, T., Lazarus, P., The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk, Carcinogenesis, 2002. 23(7): p. 1229-34.

50. Elahi, A., Bendaly, J., Zheng, Z., Muscat, J. E., Richie, J. P., Jr., Schantz, S. P., et.al. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk, Cancer, 2003. 98(4): p. 872-80.

51. Cheng, L., Sturgis, E. M., Eicher, S. A., Spitz, M. R., Wei, Q., Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck, Cancer, 2002. 94(2): p. 393-7.

52. Zheng, Y., Shen, H., Sturgis, E. M., Wang, L. E., Eicher, S. A., Strom, S. S., et.al. Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study, Carcinogenesis, 2001. 22(8): p. 1195-9.

53. Zheng, Z., Park, J. Y., Guillemette, C., Schantz, S. P., Lazarus, P., Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk, J Natl Cancer Inst, 2001. 93(18): p. 1411-8.

54. Cruz, G. D., Le Geros, R. Z., Ostroff, J. S., Hay, J. L., Kenigsberg, H., Franklin, D. M., Oral cancer knowledge, risk factors and characteristics of subjects in a large oral cancer screening program, J Am Dent Assoc, 2002. 133(8): p. 1064-71; quiz 1094.

55. Dahlstrom, K. R., Adler-Storthz, K., Etzel, C. J., Liu, Z., Dillon, L., El-Naggar, A. K., et.al. Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis, Clin Cancer Res, 2003. 9(7): p. 2620-6.

56. Herrero, R., Castellsague, X., Pawlita, M., Lissowska, J., Kee, F., Balaram, P., et.al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study, J Natl Cancer Inst, 2003. 95(23): p. 1772-83.

57. Saraiya, M., Unger, E. R., Thompson, T. D., Lynch, C. F., Hernandez, B. Y., Lyu, C. W., et.al. US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines, J Natl Cancer Inst, 2015. 107(6): p. djv086., https://www.ncbi.nlm.nih.gov/pubmed/25925419

58. Hubbers, C. U., Akgul, B., HPV and cancer of the oral cavity, Virulence, 2015. 6(3): p. 244-8., https://www.ncbi.nlm.nih.gov/pubmed/25654476

59. Yete, S., D'Souza, W., Saranath, D., High-Risk Human Papillomavirus in Oral Cancer: Clinical Implications, Oncology, 2018. 94(3): p. 133-141., https://www.ncbi.nlm.nih.gov/pubmed/29241220

60. Ndiaye, C., Mena, M., Alemany, L., Arbyn, M., Castellsague, X., Laporte, L., et.al. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis, Lancet Oncol, 2014. 15(12): p. 1319-31., https://www.ncbi.nlm.nih.gov/pubmed/25439690

61. Miller, C. S., Johnstone, B. M., Human papillomavirus as a risk factor for oral squamous cell carcinoma: a meta-analysis, 1982-1997, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001. 91(6): p. 622-35., https://www.ncbi.nlm.nih.gov/pubmed/11402272

62. Syrjanen, S., Lodi, G., von Bultzingslowen, I., Aliko, A., Arduino, P., Campisi, G., et.al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review, Oral Dis, 2011. 17 Suppl 1: p. 58-72., https://www.ncbi.nlm.nih.gov/pubmed/21382139

63. Isayeva, T., Li, Y., Maswahu, D., Brandwein-Gensler, M., Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review, Head Neck Pathol, 2012. 6 Suppl 1: p. S104-20., https://www.ncbi.nlm.nih.gov/pubmed/22782230

64. Lingen, M. W., Xiao, W., Schmitt, A., Jiang, B., Pickard, R., Kreinbrink, P., et.al. Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas, Oral Oncol, 2013. 49(1): p. 1-8., https://www.ncbi.nlm.nih.gov/pubmed/22841678

65. Reuschenbach, M., Kansy, K., Garbe, K., Vinokurova, S., Flechtenmacher, C., Toth, C., et.al. Lack of evidence of human papillomavirus-induced squamous cell carcinomas of the oral cavity in southern Germany, Oral Oncol, 2013. 49(9): p. 937-942., https://www.ncbi.nlm.nih.gov/pubmed/23608471

66. Castellsague, X., Alemany, L., Quer, M., Halec, G., Quiros, B., Tous, S., et.al. HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients, J Natl Cancer Inst, 2016. 108(6): p. djv403., https://www.ncbi.nlm.nih.gov/pubmed/26823521

67. Kreimer, A. R., Johansson, M., Yanik, E. L., Katki, H. A., Check, D. P., Lang Kuhs, K. A., et.al. Kinetics of the Human Papillomavirus Type 16 E6 Antibody Response Prior to Oropharyngeal Cancer, J Natl Cancer Inst, 2017. 109(8):, https://www.ncbi.nlm.nih.gov/pubmed/28376197

68. Anantharaman, D., Gheit, T., Waterboer, T., Abedi-Ardekani, B., Carreira, C., McKay-Chopin, S., et.al. Human papillomavirus infections and upper aero-digestive tract cancers: the ARCAGE study, J Natl Cancer Inst, 2013. 105(8): p. 536-45., https://www.ncbi.nlm.nih.gov/pubmed/23503618

69. Kreimer, A. R., Johansson, M., Waterboer, T., Kaaks, R., Chang-Claude, J., Drogen, D., et.al. Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer, J Clin Oncol, 2013. 31(21): p. 2708-15., https://www.ncbi.nlm.nih.gov/pubmed/23775966

70. Anderson, K. S., Wallstrom, G., Langseth, H., Posner, M., Cheng, J. N., Alam, R., et.al. Pre-diagnostic dynamic HPV16 IgG seropositivity and risk of oropharyngeal cancer, Oral Oncol, 2017. 73: p. 132-137., https://www.ncbi.nlm.nih.gov/pubmed/28939065

71. von Knebel Doeberitz, M., The causal role of human papillomavirus infections in non-anogenital cancers. It's time to ask for the functional evidence, Int J Cancer, 2016. 139(1): p. 9-11., https://www.ncbi.nlm.nih.gov/pubmed/26999772

72. Schwartz, S. R., Yueh, B., McDougall, J. K., Daling, J. R., Schwartz, S. M., Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study, Otolaryngol Head Neck Surg, 2001. 125(1): p. 1-9., https://www.ncbi.nlm.nih.gov/pubmed/11458206

73. Elango, K. J., Suresh, A., Erode, E. M., Subhadradevi, L., Ravindran, H. K., Iyer, S. K., et.al. Role of human papilloma virus in oral tongue squamous cell carcinoma, Asian Pac J Cancer Prev, 2011. 12(4): p. 889-96., https://www.ncbi.nlm.nih.gov/pubmed/21790221

74. Chung, C. H., Zhang, Q., Kong, C. S., Harris, J., Fertig, E. J., Harari, P. M., et.al. p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma, J Clin Oncol, 2014. 32(35): p. 3930-8., https://www.ncbi.nlm.nih.gov/pubmed/25267748

75. Li, H., Torabi, S. J., Yarbrough, W. G., Mehra, S., Osborn, H. A., Judson, B., Association of Human Papillomavirus Status at Head and Neck Carcinoma Subsites With Overall Survival, JAMA Otolaryngol Head Neck Surg, 2018. 144(6): p. 519-525., https://www.ncbi.nlm.nih.gov/pubmed/29801040

76. Kozomara, R., Jovic, N., Magic, Z., Brankovic-Magic, M., Minic, V., p53 mutations and human papillomavirus infection in oral squamous cell carcinomas: correlation with overall survival, J Craniomaxillofac Surg, 2005. 33(5): p. 342-8., https://www.ncbi.nlm.nih.gov/pubmed/16129609

77. Duray, A., Descamps, G., Decaestecker, C., Remmelink, M., Sirtaine, N., Lechien, J., et.al. Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carcinoma, Laryngoscope, 2012. 122(7): p. 1558-65., https://www.ncbi.nlm.nih.gov/pubmed/22532307

78. Lee, L. A., Huang, C. G., Liao, C. T., Lee, L. Y., Hsueh, C., Chen, T. C., et.al. Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival, PLoS One, 2012. 7(7): p. e40767., https://www.ncbi.nlm.nih.gov/pubmed/22808258

79. Lassen, P., Primdahl, H., Johansen, J., Kristensen, C. A., Andersen, E., Andersen, L. J., et.al. Impact of HPV-associated p16-expression on radiotherapy outcome in advanced oropharynx and non-oropharynx cancer, Radiother Oncol, 2014. 113(3): p. 310-6., https://www.ncbi.nlm.nih.gov/pubmed/25544647

80. Fakhry, C., Westra, W. H., Wang, S. J., van Zante, A., Zhang, Y., Rettig, E., et.al. The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer, Cancer, 2017. 123(9): p. 1566-1575., https://www.ncbi.nlm.nih.gov/pubmed/28241096

81. Zafereo, M. E., Xu, L., Dahlstrom, K. R., Viamonte, C. A., El-Naggar, A. K., Wei, Q., et.al. Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus, Oral Oncol, 2016. 56: p. 47-53., https://www.ncbi.nlm.nih.gov/pubmed/27086486

82. Pitiphat, W., Diehl, S. R., Laskaris, G., Cartsos, V., Douglass, C. W., Zavras, A. I., Factors associated with delay in the diagnosis of oral cancer, J Dent Res, 2002. 81(3): p. 192-7.

83. Jones, T. M., Hargrove, O., Lancaster, J., Fenton, J., Shenoy, A., Roland, N. J., Waiting times during the management of head and neck tumours, J Laryngol Otol, 2002. 116(4): p. 275-9.

84. Hollows, P., McAndrew, P. G., Perini, M. G., Delays in the referral and treatment of oral squamous cell carcinoma, Br Dent J, 2000. 188(5): p. 262-5.

85. West Midlands Health Technology Assessment Collaboration (WMHTAC). The effectiveness of Toludine Blue Dye as an adjunct to oral cancer screening in general dental practice: Report 24. University of Birmingham: Department of Public Health & Epidemiology; 2000.

86. Kujan, O., Glenny, A. M., Duxbury, A. J., Thakker, N., Sloan, P., Screening programmes for the early detection and prevention of oral cancer, Cochrane Database Syst Rev, 2003. p. CD004150.

87. Humphris, G. M., Freeman, R., Clarke, H. M., Risk perception of oral cancer in smokers attending primary care: a randomised controlled trial, Oral Oncol, 2004. 40(9): p. 916-24.

88. Hay, J. L., Ostroff, J. S., Cruz, G. D., LeGeros, R. Z., Kenigsberg, H., Franklin, D. M., Oral cancer risk perception among participants in an oral cancer screening program, Cancer Epidemiol Biomarkers Prev, 2002. 11(2): p. 155-8.

89. Horowitz, A. M., Canto, M. T., Child, W. L., Maryland adults' perspectives on oral cancer prevention and early detection, J Am Dent Assoc, 2002. 133(8): p. 1058-63.

90. Warnakulasuriya, K. A., Harris, C. K., Scarrott, D. M., Watt, R., Gelbier, S., Peters, T. J., et.al. An alarming lack of public awareness towards oral cancer, Br Dent J, 1999. 187(6): p. 319-22.

91. Vora, A. R., Yeoman, C. M., Hayter, J. P., Alcohol, tobacco and paan use and understanding of oral cancer risk among Asian males in Leicester, Br Dent J, 2000. 188(8): p. 444-51.

92. Humphris, G. M., Ireland, R. S., Field, E. A., Randomised trial of the psychological effect of information about oral cancer in primary care settings, Oral Oncol, 2001. 37(7): p. 548-52.

93. Humphris, G. M., Ireland, R. S., Field, E. A., Immediate knowledge increase from an oral cancer information leaflet in patients attending a primary health care facility: a randomised controlled trial, Oral Oncol, 2001. 37(1): p. 99-102.

94. Day, G. L., Blot, W. J., Second primary tumors in patients with oral cancer, Cancer, 1992. 70(1): p. 14-9.

95. de Vries, N., Van der Waal, I., Snow, G. B., Multiple primary tumours in oral cancer, Int J Oral Maxillofac Surg, 1986. 15(1): p. 85-7.

96. Day, T. A., Davis, B. K., Gillespie, M. B., Joe, J. K., Kibbey, M., Martin-Harris, B., et.al. Oral cancer treatment, Curr Treat Options Oncol, 2003. 4(1): p. 27-41.

97. Chow, Tam-Lin, Lee, Daniel Tai-Yam, Choi, Chi-Yee, Chan, Tony Tung-Fei, Lam, Siu-Ho, Prediction of simultaneous esophageal lesions in head and neck squamous cell carcinoma: a multivariate analysis, Archives of Otolaryngology -- Head & Neck Surgery, 2009. 135(9): p. 882-5.

98. Fielding, David, Agnew, Julienne, Wright, David, Hodge, Robert, Autofluorescence improves pretreatment mucosal assessment in head and neck cancer patients, Otolaryngology - Head & Neck Surgery, 2010. 142(3 Suppl 1): p. S20-6.

99. Kesting, Marco Rainer, Schurr, Christian, Robitzky, Luisa, Steinstraesser, Lars, Nieberler, Markus, Baurecht, Hansjorg, et.al. Results of esophagogastroduodenoscopy in patients with oral squamous cell carcinoma--value of endoscopic screening: 10-year experience, Journal of Oral & Maxillofacial Surgery, 2009. 67(8): p. 1649-55.

100. Kesting, Marco Rainer, Robitzky, Luisa, Al-Benna, Sammy, Steinstraesser, Lars, Baurecht, Hansjorg, Wolff, Klaus-Dietrich, et.al. Bronchoscopy screening in primary oral squamous cell carcinoma: a 10-year experience, British Journal of Oral & Maxillofacial Surgery, 2009. 47(4): p. 279-83.

101. Lee, C. T., Chang, C. Y., Lee, Y. C., Tai, C. M., Wang, W. L., Tseng, P. H., et.al. Narrow-band imaging with magnifying endoscopy for the screening of esophageal cancer in patients with primary head and neck cancers, Endoscopy, 2010. 42(8): p. 613-9.

102. Takenaka, Ryuta, Kawahara, Yoshiro, Okada, Hiroyuki, Hori, Keisuke, Inoue, Masafumi, Kawano, Seiji, et.al. Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers, American Journal of Gastroenterology, 2009. 104(12): p. 2942-8.

103. Noor, A., Stepan, L., Kao, S. S., Dharmawardana, N., Ooi, E. H., Hodge, J. C., et.al. Reviewing indications for panendoscopy in the investigation of head and neck squamous cell carcinoma, J Laryngol Otol, 2018. 132(10): p. 901-905., https://www.ncbi.nlm.nih.gov/pubmed/30289089

104. Sharma, S. J., Linke, J. J., Kroll, T., Wuerdemann, N., Klussmann, J. P., Guntinas-Lichius, O., et.al. Rigid Triple Endoscopy Improves Clinical Staging of Primary Head and Neck Cancer, Oncol Res Treat, 2018. 41(1-2): p. 35-38., https://www.ncbi.nlm.nih.gov/pubmed/29402786

105. Kerawala, C. J., Bisase, B., Lee, J., The use of examination under anaesthesia and panendoscopy in patients presenting with oral cavity and oropharyngeal squamous cell carcinoma, Ann R Coll Surg Engl, 2009. 91(7): p. 609-12., https://www.ncbi.nlm.nih.gov/pubmed/19686610

106. Vergez, S., Moriniere, S., Dubrulle, F., Salaun, P. Y., De Mones, E., Bertolus, C., et.al. Initial staging of squamous cell carcinoma of the oral cavity, larynx and pharynx (excluding nasopharynx). Part I: Locoregional extension assessment: 2012 SFORL guidelines, Eur Ann Otorhinolaryngol Head Neck Dis, 2013. 130(1): p. 39-45., https://www.ncbi.nlm.nih.gov/pubmed/23347771

107. Scottish Executive Health Department, Scottish Referral Guidelines for Suspected CancerScottish Executive Health Department, 2002.

108. Pitiphat, W., Diehl, S. R., Laskaris, G., Cartsos, V., Douglass, C. W., Zavras, A. I., Factors associated with delay in the diagnosis of oral cancer, J Dent Res, 2002. 81(3): p. 192-7.

109. Kaanders, J. H., Hordijk, G. J., Carcinoma of the larynx: the Dutch national guideline for diagnostics, treatment, supportive care and rehabilitation, Radiother Oncol, 2002. 63(3): p. 299-307.

110. Leslie, A., Fyfe, E., Guest, P., Goddard, P., Kabala, J. E., Staging of squamous cell carcinoma of the oral cavity and oropharynx: a comparison of MRI and CT in T- and N-staging, J Comput Assist Tomogr, 1999. 23(1): p. 43-9.

111. Wolmark, N., Mamounas, E. P., Baehner, F. L., Butler, S. M., Tang, G., Jamshidian, F., et.al. Prognostic Impact of the Combination of Recurrence Score and Quantitative Estrogen Receptor Expression (ESR1) on Predicting Late Distant Recurrence Risk in Estrogen Receptor-Positive Breast Cancer After 5 Years of Tamoxifen: Results From NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-28 and B-14, J Clin Oncol, 2016. 34(20): p. 2350-8., https://www.ncbi.nlm.nih.gov/pubmed/27217450

112. Bolzoni, Andrea, Cappiello, Johnny, Piazza, Cesare, Peretti, Giorgio, Maroldi, Roberto, Farina, Davide, et.al. Diagnostic accuracy of magnetic resonance imaging in the assessment of mandibular involvement in oral-oropharyngeal squamous cell carcinoma: a prospective study, Archives of Otolaryngology -- Head & Neck Surgery, 2004. 130(7): p. 837-43.

113. Imaizumi, A., Yoshino, N., Yamada, I., Nagumo, K., Amagasa, T., Omura, K., et.al. A potential pitfall of MR imaging for assessing mandibular invasion of squamous cell carcinoma in the oral cavity, Ajnr: American Journal of Neuroradiology, 2006. 27(1): p. 114-22.

114. Van Cann, E. M., Koole, R., Oyen, W. J. G., de Rooy, J. W. J., de Wilde, P. C., Slootweg, P. J., et.al. Assessment of mandibular invasion of squamous cell carcinoma by various modes of imaging: constructing a diagnostic algorithm, International Journal of Oral & Maxillofacial Surgery, 2008. 37(6): p. 535-41.

115. Hendrikx, A. W. F., Maal, T., Dieleman, F., Van Cann, E. M., Merkx, M. A. W., Cone-beam CT in the assessment of mandibular invasion by oral squamous cell carcinoma: results of the preliminary study, International Journal of Oral and Maxillofacial Surgery, 2010. 39 (5): p. 436-439.

116. Goerres, Gerhard W., Schmid, Daniel T., Schuknecht, Bernhard, Eyrich, Gerold K., Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT.[Erratum appears in Radiology. 2006 Apr;239(1):303], Radiology, 2005. 237(1): p. 281-7.

117. Hafidh, M. A., Lacy, P. D., Hughes, J. P., Duffy, G., Timon, C. V., Evaluation of the impact of addition of PET to CT and MR scanning in the staging of patients with head and neck carcinomas, European Archives of Oto-Rhino-Laryngology, 2006. 263(9): p. 853-9.

118. Krabbe, Christiaan A., Dijkstra, Pieter U., Pruim, Jan, van der Laan, Bernard F. M., van der Wal, Jacqueline E., Gravendeel, Joost P., et.al. FDG PET in oral and oropharyngeal cancer. Value for confirmation of N0 neck and detection of occult metastases, Oral Oncology, 2008. 44(1): p. 31-6.

119. Nahmias, Claude, Carlson, Eric R., Duncan, Lisa D., Blodgett, Todd M., Kennedy, Jason, Long, Misty J., et.al. Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer, Journal of Oral & Maxillofacial Surgery, 2007. 65(12): p. 2524-35.

120. Seitz, Oliver, Chambron-Pinho, Nicole, Middendorp, Markus, Sader, Rober, Mack, Martin, Vogl, Thomas J., et.al. 18F-Fluorodeoxyglucose-PET/CT to evaluate tumor, nodal disease, and gross tumor volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen, Neuroradiology, 2009. 51(10): p. 677-86.

121. Wax, M. K., Myers, L. L., Gona, J. M., Husain, S. S., Nabi, H. A., The role of positron emission tomography in the evaluation of the N-positive neck, Otolaryngol Head Neck Surg, 2003. 129(3): p. 163-7.

122. Yen, Tzu-Chen, Chang, Joseph Tung-Chieh, Ng, Shu-Hang, Chang, Yu-Chen, Chan, Sheng-Chieh, Wang, Hung-Ming, et.al. Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: comparison with head and neck CT/MRI and histopathology, Journal of Nuclear Medicine, 2005. 46(5): p. 775-81.

123. Rao, L. P., Das, S. R., Mathews, A., Naik, B. R., Chacko, E., Pandey, M., Mandibular invasion in oral squamous cell carcinoma: investigation by clinical examination and orthopantomogram, International Journal of Oral & Maxillofacial Surgery, 2004. 33(5): p. 454-7.

124. Wilson JA, editor, Effective head and neck cancer management: consensus documentBritish Association of Otorhinolaryngologists, Head and Neck Surgeons, 1998.

125. Leslie, A., Fyfe, E., Guest, P., Goddard, P., Kabala, J. E., Staging of squamous cell carcinoma of the oral cavity and oropharynx: a comparison of MRI and CT in T- and N-staging, J Comput Assist Tomogr, 1999. 23(1): p. 43-9.

126. Kaanders, J. H., Hordijk, G. J., Carcinoma of the larynx: the Dutch national guideline for diagnostics, treatment, supportive care and rehabilitation, Radiother Oncol, 2002. 63(3): p. 299-307.

127. Vidiri, A., Ruscito, P., Pichi, B., Pellini, R., Covello, R., Sperduti, I., et.al. Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor, Journal of Experimental and Clinical Cancer Research, 2007. 26 (4): p. 575-582.

128. Vidiri, Antonello, Guerrisi, Antonino, Pellini, Raul, Manciocco, Valentina, Covello, Renato, Mattioni, Oreste, et.al. Multi-detector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the evaluation of the mandibular invasion by squamous cell carcinomas (SCC) of the oral cavity. Correlation with pathological data, Journal of Experimental & Clinical Cancer Research, 2010. 29: p. 73.

129. Babin, E., Desmonts, C., Hamon, M., Benateau, H., Hitier, M., PET/CT for assessing mandibular invasion by intraoral squamous cell carcinomas, Clinical Otolaryngology, 2008. 33(1): p. 47-51.

130. Baek, Chung-Hwan, Chung, Man Ki, Son, Young-Ik, Choi, Joon Young, Kim, Hyung-Jin, Yim, Yoo Jeong, et.al. Tumor volume assessment by 18F-FDG PET/CT in patients with oral cavity cancer with dental artifacts on CT or MR images, Journal of Nuclear Medicine, 2008. 49(9): p. 1422-8.

131. Pauleit, Dirk, Zimmermann, Andre, Stoffels, Gabriele, Bauer, Dagmar, Risse, Jorn, Fluss, Michael O., et.al. 18F-FET PET compared with 18F-FDG PET and CT in patients with head and neck cancer, Journal of Nuclear Medicine, 2006. 47(2): p. 256-61.

132. Goerres, Gerhard W., Schmid, Daniel T., Schuknecht, Bernhard, Eyrich, Gerold K., Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT.[Erratum appears in Radiology. 2006 Apr;239(1):303], Radiology, 2005. 237(1): p. 281-7.

133. Yen, Tzu-Chen, Chang, Joseph Tung-Chieh, Ng, Shu-Hang, Chang, Yu-Chen, Chan, Sheng-Chieh, Wang, Hung-Ming, et.al. Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: comparison with head and neck CT/MRI and histopathology, Journal of Nuclear Medicine, 2005. 46(5): p. 775-81.

134. Wax, M. K., Myers, L. L., Gona, J. M., Husain, S. S., Nabi, H. A., The role of positron emission tomography in the evaluation of the N-positive neck, Otolaryngol Head Neck Surg, 2003. 129(3): p. 163-7.

135. Roh, Jong-Lyel, Yeo, Nam-Kyung, Kim, Jae Seung, Lee, Jeong Hyun, Cho, Kyung-Ja, Choi, Seung-Ho, et.al. Utility of 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography and positron emission tomography/computed tomography imaging in the preoperative staging of head and neck squamous cell carcinoma, Oral Oncology, 2007. 43(9): p. 887-93.

136. Hafidh, M. A., Lacy, P. D., Hughes, J. P., Duffy, G., Timon, C. V., Evaluation of the impact of addition of PET to CT and MR scanning in the staging of patients with head and neck carcinomas, European Archives of Oto-Rhino-Laryngology, 2006. 263(9): p. 853-9.

137. Krabbe, Christiaan A., Dijkstra, Pieter U., Pruim, Jan, van der Laan, Bernard F. M., van der Wal, Jacqueline E., Gravendeel, Joost P., et.al. FDG PET in oral and oropharyngeal cancer. Value for confirmation of N0 neck and detection of occult metastases, Oral Oncology, 2008. 44(1): p. 31-6.

138. Nahmias, Claude, Carlson, Eric R., Duncan, Lisa D., Blodgett, Todd M., Kennedy, Jason, Long, Misty J., et.al. Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer, Journal of Oral & Maxillofacial Surgery, 2007. 65(12): p. 2524-35.

139. Imaizumi, A., Yoshino, N., Yamada, I., Nagumo, K., Amagasa, T., Omura, K., et.al. A potential pitfall of MR imaging for assessing mandibular invasion of squamous cell carcinoma in the oral cavity, Ajnr: American Journal of Neuroradiology, 2006. 27(1): p. 114-22.

140. Van Cann, E. M., Koole, R., Oyen, W. J., de Rooy, J. W., de Wilde, P. C., Slootweg, P. J., et.al. Assessment of mandibular invasion of squamous cell carcinoma by various modes of imaging: constructing a diagnostic algorithm, Int J Oral Maxillofac Surg, 2008. 37(6): p. 535-41., https://www.ncbi.nlm.nih.gov/pubmed/18406107

141. Wiener, Edzard, Pautke, Christoph, Link, Thomas M., Neff, Andreas, Kolk, Andreas, Comparison of 16-slice MSCT and MRI in the assessment of squamous cell carcinoma of the oral cavity, European Journal of Radiology, 2006. 58(1): p. 113-8.

142. Bolzoni, Andrea, Cappiello, Johnny, Piazza, Cesare, Peretti, Giorgio, Maroldi, Roberto, Farina, Davide, et.al. Diagnostic accuracy of magnetic resonance imaging in the assessment of mandibular involvement in oral-oropharyngeal squamous cell carcinoma: a prospective study, Archives of Otolaryngology -- Head & Neck Surgery, 2004. 130(7): p. 837-43.

143. Seitz, Oliver, Chambron-Pinho, Nicole, Middendorp, Markus, Sader, Rober, Mack, Martin, Vogl, Thomas J., et.al. 18F-Fluorodeoxyglucose-PET/CT to evaluate tumor, nodal disease, and gross tumor volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen, Neuroradiology, 2009. 51(10): p. 677-86.

144. Gu, Dong Hyeon, Yoon, Dae Young, Park, Chan Hee, Chang, Suk Ki, Lim, Kyoung Ja, Seo, Young Lan, et.al. CT, MR, (18)F-FDG PET/CT, and their combined use for the assessment of mandibular invasion by squamous cell carcinomas of the oral cavity, Acta Radiologica, 2010. 51(10): p. 1111-9.

145. Kyzas, P. A., Evangelou, E., Denaxa-Kyza, D., Ioannidis, J. P., 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis, J Natl Cancer Inst, 2008. 100(10): p. 712-20.

146. Dammann, Florian, Horger, Marius, Mueller-Berg, Marcus, Schlemmer, Heinz, Claussen, Claus D., Hoffman, Juergen, et.al. Rational diagnosis of squamous cell carcinoma of the head and neck region: comparative evaluation of CT, MRI, and 18FDG PET.[Erratum appears in AJR Am J Roentgenol. 2005 Jun;184(6):1968], AJR, 2005. 184(4): p. 1326-31.

147. Ng, Shu-Hang, Yen, Tzu-Chen, Chang, Joseph Tung-Chieh, Chan, Sheng-Chieh, Ko, Sheung-Fat, Wang, Hung-Ming, et.al. Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck, Journal of Clinical Oncology, 2006. 24(27): p. 4371-6.

148. Ng, Shu-Hang, Yen, Tzu-Chen, Liao, Chun-Ta, Chang, Joseph Tung-Chieh, Chan, Sheng-Chieh, Ko, Sheung-Fat, et.al. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation, Journal of Nuclear Medicine, 2005. 46(7): p. 1136-43.

149. Sumi, Misa, Kimura, Yasuo, Sumi, Tadateru, Nakamura, Takashi, Diagnostic performance of MRI relative to CT for metastatic nodes of head and neck squamous cell carcinomas, Journal of Magnetic Resonance Imaging, 2007. 26(6): p. 1626-33.

150. van den Brekel, M. W., Castelijns, J. A., Stel, H. V., Golding, R. P., Meyer, C. J., Snow, G. B., Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study, Eur Arch Otorhinolaryngol, 1993. 250(1): p. 11-7.

151. Wiener, Edzard, Pautke, Christoph, Link, Thomas M., Neff, Andreas, Kolk, Andreas, Comparison of 16-slice MSCT and MRI in the assessment of squamous cell carcinoma of the oral cavity, European Journal of Radiology, 2006. 58(1): p. 113-8.

152. Adams, S., Baum, R. P., Stuckensen, T., Bitter, K., Hor, G., Prospective comparison of 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer, Eur J Nucl Med, 1998. 25(9): p. 1255-60.

153. Stokkel, M. P., ten Broek, F. W., Hordijk, G. J., Koole, R., van Rijk, P. P., Preoperative evaluation of patients with primary head and neck cancer using dual-head 18fluorodeoxyglucose positron emission tomography, Ann Surg, 2000. 231(2): p. 229-34.

154. Takes, R. P., Righi, P., Meeuwis, C. A., Manni, J. J., Knegt, P., Marres, H. A., et.al. The value of ultrasound with ultrasound-guided fine-needle aspiration biopsy compared to computed tomography in the detection of regional metastases in the clinically negative neck, Int J Radiat Oncol Biol Phys, 1998. 40(5): p. 1027-32.

155. Balogova, S., Perie, S., Kerrou, K., Grahek, D., Montravers, F., Angelard, B., et.al. Prospective comparison of FDG and FET PET/CT in patients with head and neck squamous cell carcinoma, Molecular Imaging & Biology, 2008. 10(6): p. 364-73.

156. Gencoglu, U., Guneren, E., Gozu, A., Ozsoy, Z., Vural, G., The coherence between fine needle aspiration cytology and histopathology of palpable neck nodes in lower lip carcinoma patients, European Journal of Plastic Surgery, 2003. 26 (2): p. 82-84.

157. Kim, S. Y., Roh, J. L., Kim, J. S., Ryu, C. H., Lee, J. H., Cho, K. J., et.al. Utility of FDG PET in patients with squamous cell carcinomas of the oral cavity, European Journal of Surgical Oncology, 2008. 34(2): p. 208-15.

158. Roh, Jong-Lyel, Yeo, Nam-Kyung, Kim, Jae Seung, Lee, Jeong Hyun, Cho, Kyung-Ja, Choi, Seung-Ho, et.al. Utility of 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography and positron emission tomography/computed tomography imaging in the preoperative staging of head and neck squamous cell carcinoma, Oral Oncology, 2007. 43(9): p. 887-93.

159. Schwartz, David L., Ford, Eric, Rajendran, Joseph, Yueh, Bevan, Coltrera, Marc D., Virgin, Jeffery, et.al. FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma, International Journal of Radiation Oncology, Biology, Physics, 2005. 61(1): p. 129-36.

160. Jeong, Han-Sin, Baek, Chung-Hwan, Son, Young-Ik, Ki Chung, Man, Kyung Lee, Dong, Young Choi, Joon, et.al. Use of integrated 18F-FDG PET/CT to improve the accuracy of initial cervical nodal evaluation in patients with head and neck squamous cell carcinoma, Head & Neck, 2007. 29(3): p. 203-10.

161. van den Brekel, M. W., Castelijns, J. A., Snow, G. B., Diagnostic evaluation of the neck, Otolaryngol Clin North Am, 1998. 31(4): p. 601-20.

162. Dammann, Florian, Horger, Marius, Mueller-Berg, Marcus, Schlemmer, Heinz, Claussen, Claus D., Hoffman, Juergen, et.al. Rational diagnosis of squamous cell carcinoma of the head and neck region: comparative evaluation of CT, MRI, and 18FDG PET.[Erratum appears in AJR Am J Roentgenol. 2005 Jun;184(6):1968], AJR, 2005. 184(4): p. 1326-31.

163. Ng, Shu-Hang, Yen, Tzu-Chen, Chang, Joseph Tung-Chieh, Chan, Sheng-Chieh, Ko, Sheung-Fat, Wang, Hung-Ming, et.al. Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck, Journal of Clinical Oncology, 2006. 24(27): p. 4371-6.

164. Schroeder, Ursula, Dietlein, Markus, Wittekindt, Claus, Ortmann, Monika, Stuetzer, Hartmut, Vent, Julia, et.al. Is there a need for positron emission tomography imaging to stage the N0 neck in T1-T2 squamous cell carcinoma of the oral cavity or oropharynx?, Annals of Otology, Rhinology & Laryngology, 2008. 117(11): p. 854-63.

165. Nakamoto, Yuji, Tamai, Ken, Saga, Tsuneo, Higashi, Tatsuya, Hara, Tadashi, Suga, Tsuyoshi, et.al. Clinical value of image fusion from MR and PET in patients with head and neck cancer, Molecular Imaging & Biology, 2009. 11(1): p. 46-53.

166. Schwartz, David L., Ford, Eric, Rajendran, Joseph, Yueh, Bevan, Coltrera, Marc D., Virgin, Jeffery, et.al. FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma, International Journal of Radiation Oncology, Biology, Physics, 2005. 61(1): p. 129-36.

167. Jeong, H. S., Baek, C. H., Son, Y. I., Cho, D. Y., Man, K. C., Min, J. Y., et.al. Sentinel lymph node radiolocalization with 99mTc filtered tin colloid in clinically node-negative squamous cell carcinomas of the oral cavity, Journal of Korean Medical Science, 2006. 21 (5): p. 865-870.

168. Stokkel, M. P., ten Broek, F. W., Hordijk, G. J., Koole, R., van Rijk, P. P., Preoperative evaluation of patients with primary head and neck cancer using dual-head 18fluorodeoxyglucose positron emission tomography, Ann Surg, 2000. 231(2): p. 229-34.

169. Adams, S., Baum, R. P., Stuckensen, T., Bitter, K., Hor, G., Prospective comparison of 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer, Eur J Nucl Med, 1998. 25(9): p. 1255-60.

170. Pentenero, Monica, Cistaro, Angela, Brusa, Mario, Ferraris, Maria Maddalena, Pezzuto, Carla, Carnino, Riccardo, et.al. Accuracy of 18F-FDG-PET/CT for staging of oral squamous cell carcinoma, Head & Neck, 2008. 30(11): p. 1488-96.

171. Wensing, Bart M., Vogel, Wouter V., Marres, Henri A. M., Merkx, Matthias A. W., Postema, Ernst J., Oyen, Wim J. G., et.al. FDG-PET in the clinically negative neck in oral squamous cell carcinoma.[Erratum appears in Laryngoscope. 2006 Jul;116(7 Pt 1):1302], Laryngoscope, 2006. 116(5): p. 809-13.

172. Yamazaki, Yutaka, Saitoh, Masaaki, Notani, Ken-ichi, Tei, Kanchu, Totsuka, Yasunori, Takinami, Shu-ichi, et.al. Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer, Annals of Nuclear Medicine, 2008. 22(3): p. 177-84.

173. Piao, Yongnan, Bold, Bayarkhuu, Tayier, Abulajiang, Ishida, Ryuji, Omura, Ken, Okada, Norihiko, et.al. Evaluation of 18F-FDG PET/CT for diagnosing cervical nodal metastases in patients with oral cavity or oropharynx carcinoma, Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 2009. 108(6): p. 933-8.

174. Hohlweg-Majert, Bettina, Metzger, Marc C., Voss, Pit J., Holzle, Frank, Wolff, Klaus-Dietrich, Schulze, Dirk, Preoperative cervical lymph node size evaluation in patients with malignant head/neck tumors: comparison between ultrasound and computer tomography, Journal of Cancer Research & Clinical Oncology, 2009. 135(6): p. 753-9.

175. Thomsen, J. B., Sorensen, J. A., Grupe, P., Karstoft, J., Krogdahl, A., Staging N0 oral cancer: lymphoscintigraphy and conventional imaging, Acta Radiologica, 2005. 46(5): p. 492-6.

176. To, E. W. H., Tsang, W. M., Cheng, J., Lai, E., Pang, P., Ahuja, A. T., et.al. Is neck ultrasound necessary for early stage oral tongue carcinoma with clinically N0 neck?, Dento-Maxillo-Facial Radiology, 2003. 32(3): p. 156-9.

177. Borgemeester, Maarten C., van den Brekel, Michiel W. M., van Tinteren, Harm, Smeele, Ludi E., Pameijer, Frank A., van Velthuysen, Marie-Louise F., et.al. Ultrasound-guided aspiration cytology for the assessment of the clinically N0 neck: factors influencing its accuracy, Head & Neck, 2008. 30(11): p. 1505-13.

178. Brouwer, Jolijn, de Bree, Remco, Comans, Emile F. I., Castelijns, Jonas A., Hoekstra, Otto S., Leemans, C. Rene, Positron emission tomography using [18F]fluorodeoxyglucose (FDG-PET) in the clinically negative neck: is it likely to be superior?, European Archives of Oto-Rhino-Laryngology, 2004. 261(9): p. 479-83.

179. Takes, R. P., Righi, P., Meeuwis, C. A., Manni, J. J., Knegt, P., Marres, H. A., et.al. The value of ultrasound with ultrasound-guided fine-needle aspiration biopsy compared to computed tomography in the detection of regional metastases in the clinically negative neck, Int J Radiat Oncol Biol Phys, 1998. 40(5): p. 1027-32.

180. Gencoglu, U., Guneren, E., Gozu, A., Ozsoy, Z., Vural, G., The coherence between fine needle aspiration cytology and histopathology of palpable neck nodes in lower lip carcinoma patients, European Journal of Plastic Surgery, 2003. 26 (2): p. 82-84.

181. Andrle, J., Schartinger, V. H., Schwentner, I., Deibl, M., Sprinzl, G. M., Initial staging examinations for head and neck squamous cell carcinoma: are they appropriate?, J Laryngol Otol, 2009. 123(8): p. 885-8.

182. Arunachalam, P. S., Putnam, G., Jennings, P., Messersmith, R., Robson, A. K., Role of computerized tomography (CT) scan of the chest in patients with newly diagnosed head and neck cancers, Clin Otolaryngol Allied Sci, 2002. 27(12383307): p. 409-411.

183. Ghosh, Samit K., Roland, Nicholas J., Kumar, Aman, Tandon, Sankalap, Lancaster, Jeffrey L., Jackson, Shaun R., et.al. Detection of synchronous lung tumors in patients presenting with squamous cell carcinoma of the head and neck, Head & Neck, 2009. 31(12): p. 1563-70.

184. Loh, Kwok Seng, Brown, Dale H., Baker, James T., Gilbert, Ralph W., Gullane, Patrick J., Irish, Jonathan C., A rational approach to pulmonary screening in newly diagnosed head and neck cancer, Head & Neck, 2005. 27(11): p. 990-4.

185. Bongers, Vivian, Hobbelink, Monique G., van Rijk, Peter P., Hordijk, Gert-Jan, Cost-effectiveness of dual-head 18F-fluorodeoxyglucose PET for the detection of recurrent laryngeal cancer, Cancer Biother Radiopharm, 2002. 17(12136522): p. 303-306.

186. Lonneux, M., Lawson, G., Ide, C., Bausart, R., Remacle, M., Pauwels, S., Positron emission tomography with fluorodeoxyglucose for suspected head and neck tumor recurrence in the symptomatic patient, Laryngoscope, 2000. 110(10983949): p. 1493-1497.

187. Nakamoto, Yuji, Tamai, Ken, Saga, Tsuneo, Higashi, Tatsuya, Hara, Tadashi, Suga, Tsuyoshi, et.al. Clinical value of image fusion from MR and PET in patients with head and neck cancer, Molecular Imaging & Biology, 2009. 11(1): p. 46-53.

188. Haughey, B. H., Gates, G. A., Arfken, C. L., Harvey, J., Meta-analysis of second malignant tumors in head and neck cancer: the case for an endoscopic screening protocol, Ann Otol Rhinol Laryngol, 1992. 101(2 Pt 1): p. 105-12.

189. de Bree, R., Deurloo, E. E., Snow, G. B., Leemans, C. R., Screening for distant metastases in patients with head and neck cancer, Laryngoscope, 2000. 110(3 Pt 1): p. 397-401.

190. Warner, Giles C., Cox, Graham J., Evaluation of chest radiography versus chest computed tomography in screening for pulmonary malignancy in advanced head and neck cancer, J Otolaryngol, 2003. 32(12866595): p. 107-109.

191. Keith, D. J. W., Ong, T. K., Martin, I. C., The role of thoracic computed tomography in staging newly-diagnosed oral squamous cell carcinoma, British Journal of Oral & Maxillofacial Surgery, 2006. 44(3): p. 198-202.

192. Bisase, Brian, Kerawala, Cyrus, Lee, Jonathan, The role of computed tomography of the chest in the staging of early squamous cell carcinoma of the tongue, British Journal of Oral & Maxillofacial Surgery, 2008. 46(5): p. 367-9.

193. van den Brekel, M. W., Castelijns, J. A., Stel, H. V., Golding, R. P., Meyer, C. J., Snow, G. B., Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study, Eur Arch Otorhinolaryngol, 1993. 250(1): p. 11-7.

194. Arunachalam, P. S., Putnam, G., Jennings, P., Messersmith, R., Robson, A. K., Role of computerized tomography (CT) scan of the chest in patients with newly diagnosed head and neck cancers, Clin Otolaryngol Allied Sci, 2002. 27(12383307): p. 409-411.

195. Ghosh, Samit K., Roland, Nicholas J., Kumar, Aman, Tandon, Sankalap, Lancaster, Jeffrey L., Jackson, Shaun R., et.al. Detection of synchronous lung tumors in patients presenting with squamous cell carcinoma of the head and neck, Head & Neck, 2009. 31(12): p. 1563-70.

196. Kyzas, P. A., Evangelou, E., Denaxa-Kyza, D., Ioannidis, J. P., 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis, J Natl Cancer Inst, 2008. 100(10): p. 712-20.

197. Bongers, Vivian, Hobbelink, Monique G., van Rijk, Peter P., Hordijk, Gert-Jan, Cost-effectiveness of dual-head 18F-fluorodeoxyglucose PET for the detection of recurrent laryngeal cancer, Cancer Biother Radiopharm, 2002. 17(12136522): p. 303-306.

198. Lonneux, M., Lawson, G., Ide, C., Bausart, R., Remacle, M., Pauwels, S., Positron emission tomography with fluorodeoxyglucose for suspected head and neck tumor recurrence in the symptomatic patient, Laryngoscope, 2000. 110(10983949): p. 1493-1497.

199. Jungehulsing, M., Scheidhauer, K., Damm, M., Pietrzyk, U., Eckel, H., Schicha, H., et.al. 2[F]-fluoro-2-deoxy-D-glucose positron emission tomography is a sensitive tool for the detection of occult primary cancer (carcinoma of unknown primary syndrome) with head and neck lymph node manifestation, Otolaryngol Head Neck Surg, 2000. 123(3): p. 294-301.

200. Johansen, Jorgen, Eigtved, Annika, Buchwald, Christian, Theilgaard, Sune A., Hansen, Hanne S., Implication of 18F-fluoro-2-deoxy-D-glucose positron emission tomography on management of carcinoma of unknown primary in the head and neck: a Danish cohort study, Laryngoscope, 2002. 112(12439171): p. 2009-2014.

201. Regelink, G., Brouwer, J., de Bree, R., Pruim, J., van der Laan, B. F., Vaalburg, W., et.al. Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities, Eur J Nucl Med Mol Imaging, 2002. 29(8): p. 1024-30.

202. Reviews., EBM, Multi-agent chemotherapy for early breast cancer, Cochrane Database of Systematic Review., 2003.

203. Coatesworth, Andrew P., MacLennan, Ken, Squamous cell carcinoma of the upper aerodigestive tract: the prevalence of microscopic extracapsular spread and soft tissue deposits in the clinically N0 neck, Head Neck, 2002. 24(11891957): p. 258-261.

204. Carinci, F., Pelucchi, S., Farina, A., De Franciscis, G., Calearo, C., Extension as a prognostic factor in oropharyngeal cancer: largest mucosal dimension compared with number of (sub)sites involved, Br J Oral Maxillofac Surg, 1998. 36(6): p. 440-445.

205. Hirvikoski, P., Kumpulainen, E., Virtaniemi, J., Pirinen, R., Salmi, L., Halonen, P., et.al. Enhanced apoptosis correlates with poor survival in patients with laryngeal cancer but not with cell proliferation, bcl-2 or p53 expression, Eur J Cancer, 1999. 35(10448265): p. 231-237.

206. Fortin, A., Couture, C., Doucet, R., Albert, M., Allard, J., Tetu, B., Does histologic grade have a role in the management of head and neck cancers?, J Clin Oncol, 2001. 19(11689578): p. 4107-4116.

207. Yamazaki, H., Inoue, T., Teshima, T., Tanaka, E., Koizumi, M., Kagawa, K., et.al. Tongue cancer treated with brachytherapy: is thickness of tongue cancer a prognostic factor for regional control?, Anticancer Res, 1998. 18(2B): p. 1261-5.

208. O'Brien, C. J., Lauer, C. S., Fredricks, S., Clifford, A. R., McNeil, E. B., Bagia, J. S., et.al. Tumor thickness influences prognosis of T1 and T2 oral cavity cancer--but what thickness?, Head Neck, 2003. 25(11): p. 937-45.

209. Nishimaki, Tadashi, Kanda, Tatsuo, Nakagawa, Satoru, Kosugi, Shin-ichi, Tanabe, Tadashi, Hatakeyama, Katsuyoshi, Outcomes and prognostic factors after surgical resection of hypopharyngeal and cervical esophageal carcinomas, Int Surg, 2002. 87(1): p. 38-44.

210. Recht, A., Edge, S. B., Solin, L. J., Robinson, D. S., Estabrook, A., Fine, R. E., et.al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology, J Clin Oncol, 2001. 19(5): p. 1539-69., https://www.ncbi.nlm.nih.gov/pubmed/11230499

211. Ang, K. Kian, Berkey, Brian A., Tu, Xiaoyu, Zhang, Hua-Zhong, Katz, Ruth, Hammond, Elizabeth H., et.al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma, Cancer Res, 2002. 62(12499279): p. 7350-7356.

212. Spiro, R. H., Guillamondegui, O., Paulino, A. F., Huvos, A. G., Pattern of invasion and margin assessment in patients with oral tongue cancer, Head Neck, 1999. 21(5): p. 408-413.

213. Wong, R. J., Keel, S. B., Glynn, R. J., Varvares, M. A., Histological pattern of mandibular invasion by oral squamous cell carcinoma, Laryngoscope, 2000. 110(1): p. 65-72.

214. Weijers, M., Snow, G. B., Bezemer, P. D., van der Wal, J. E., van der Waal, I., The clinical relevance of epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma: an analysis of 37 patients, J Oral Pathol Med, 2002. 31(11896817): p. 11-15.

215. Bailey, J. S., Blanchaert, R. H., Ord, R. A., Management of oral squamous cell carcinoma treated with inadequate excisional biopsy, J Oral Maxillofac Surg, 2001. 59(11526566): p. 1007-1010.

216. McMahon, J., O'Brien, C. J., Pathak, I., Hamill, R., McNeil, E., Hammersley, N., et.al. Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and oropharyngeal cancer, Br J Oral Maxillofac Surg, 2003. 41(4): p. 224-31.

217. Slootweg, Pieter J., Hordijk, Gert Jan, Schade, Yolanda, van Es, Robert J. J., Koole, Ronald, Treatment failure and margin status in head and neck cancer. A critical view on the potential value of molecular pathology, Oral Oncol, 2002. 38(12110346): p. 500-503.

218. Ribeiro, N. F. F., Godden, D. R. P., Wilson, G. E., Butterworth, D. M., Woodwards, R. T. M., Do frozen sections help achieve adequate surgical margins in the resection of oral carcinoma?, Int J Oral Maxillofac Surg, 2003. 32(12729775): p. 152-158.

219. DiNardo, L. J., Lin, J., Karageorge, L. S., Powers, C. N., Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery, Laryngoscope, 2000. 110(10 Pt 1): p. 1773-6.

220. Spector, J. G., Sessions, D. G., Haughey, B. H., Chao, K. S., Simpson, J., El Mofty, S., et.al. Delayed regional metastases, distant metastases, and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx, Laryngoscope, 2001. 111(11404625): p. 1079-1087.

221. Ozdek, A., Sarac, S., Akyol, M. U., Unal, O. F., Sungur, A., Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas, Eur Arch Otorhinolaryngol, 2000. 257(11052252): p. 389-392.

222. Ang, K. Kian, Berkey, Brian A., Tu, Xiaoyu, Zhang, Hua-Zhong, Katz, Ruth, Hammond, Elizabeth H., et.al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma, Cancer Res, 2002. 62(12499279): p. 7350-7356.

223. Bailey, J. S., Blanchaert, R. H., Ord, R. A., Management of oral squamous cell carcinoma treated with inadequate excisional biopsy, J Oral Maxillofac Surg, 2001. 59(11526566): p. 1007-1010.

224. Carinci, F., Pelucchi, S., Farina, A., De Franciscis, G., Calearo, C., Extension as a prognostic factor in oropharyngeal cancer: largest mucosal dimension compared with number of (sub)sites involved, Br J Oral Maxillofac Surg, 1998. 36(6): p. 440-445.

225. Coatesworth, Andrew P., MacLennan, Ken, Squamous cell carcinoma of the upper aerodigestive tract: the prevalence of microscopic extracapsular spread and soft tissue deposits in the clinically N0 neck, Head Neck, 2002. 24(11891957): p. 258-261.

226. DiNardo, L. J., Lin, J., Karageorge, L. S., Powers, C. N., Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery, Laryngoscope, 2000. 110(10 Pt 1): p. 1773-6.

227. Fortin, A., Couture, C., Doucet, R., Albert, M., Allard, J., Tetu, B., Does histologic grade have a role in the management of head and neck cancers?, J Clin Oncol, 2001. 19(11689578): p. 4107-4116.

228. Hirvikoski, P., Kumpulainen, E., Virtaniemi, J., Pirinen, R., Salmi, L., Halonen, P., et.al. Enhanced apoptosis correlates with poor survival in patients with laryngeal cancer but not with cell proliferation, bcl-2 or p53 expression, Eur J Cancer, 1999. 35(10448265): p. 231-237.

229. McMahon, J., O'Brien, C. J., Pathak, I., Hamill, R., McNeil, E., Hammersley, N., et.al. Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and oropharyngeal cancer, Br J Oral Maxillofac Surg, 2003. 41(4): p. 224-31.

230. Nishimaki, Tadashi, Kanda, Tatsuo, Nakagawa, Satoru, Kosugi, Shin-ichi, Tanabe, Tadashi, Hatakeyama, Katsuyoshi, Outcomes and prognostic factors after surgical resection of hypopharyngeal and cervical esophageal carcinomas, Int Surg, 2002. 87(1): p. 38-44.

231. O'Brien, C. J., Lauer, C. S., Fredricks, S., Clifford, A. R., McNeil, E. B., Bagia, J. S., et.al. Tumor thickness influences prognosis of T1 and T2 oral cavity cancer--but what thickness?, Head Neck, 2003. 25(11): p. 937-45.

232. Ribeiro, N. F. F., Godden, D. R. P., Wilson, G. E., Butterworth, D. M., Woodwards, R. T. M., Do frozen sections help achieve adequate surgical margins in the resection of oral carcinoma?, Int J Oral Maxillofac Surg, 2003. 32(12729775): p. 152-158.

233. Slootweg, Pieter J., Hordijk, Gert Jan, Schade, Yolanda, van Es, Robert J. J., Koole, Ronald, Treatment failure and margin status in head and neck cancer. A critical view on the potential value of molecular pathology, Oral Oncol, 2002. 38(12110346): p. 500-503.

234. Spiro, R. H., Guillamondegui, O., Paulino, A. F., Huvos, A. G., Pattern of invasion and margin assessment in patients with oral tongue cancer, Head Neck, 1999. 21(5): p. 408-413.

235. Weijers, M., Snow, G. B., Bezemer, P. D., van der Wal, J. E., van der Waal, I., The clinical relevance of epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma: an analysis of 37 patients, J Oral Pathol Med, 2002. 31(11896817): p. 11-15.

236. Wong, R. J., Keel, S. B., Glynn, R. J., Varvares, M. A., Histological pattern of mandibular invasion by oral squamous cell carcinoma, Laryngoscope, 2000. 110(1): p. 65-72.

237. Yamazaki, H., Inoue, T., Teshima, T., Tanaka, E., Koizumi, M., Kagawa, K., et.al. Tongue cancer treated with brachytherapy: is thickness of tongue cancer a prognostic factor for regional control?, Anticancer Res, 1998. 18(2B): p. 1261-5.

238. Brasilino de Carvalho, M., Quantitative analysis of the extent of extracapsular invasion and its prognostic significance: a prospective study of 170 cases of carcinoma of the larynx and hypopharynx, Head Neck, 1998. 20(1): p. 16-21.

239. Brasilino de Carvalho, M., Quantitative analysis of the extent of extracapsular invasion and its prognostic significance: a prospective study of 170 cases of carcinoma of the larynx and hypopharynx, Head Neck, 1998. 20(1): p. 16-21.

240. Enepekides, D. J., Sultanem, K., Nguyen, C., Shenouda, G., Black, M. J., Rochon, L., Occult cervical metastases: immunoperoxidase analysis of the pathologically negative neck, Otolaryngol Head Neck Surg, 1999. 120(5): p. 713-717.

241. Esposito, E. D., Motta, S., Cassiano, B., Motta, G., Occult lymph node metastases in supraglottic cancers of the larynx, Otolaryngol Head Neck Surg, 2001. 124(3): p. 253-7.

242. Greenberg, Jayson S., Fowler, Robert, Gomez, Jose, Mo, Vivian, Roberts, Dianna, El Naggar, Adel K., et.al. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer, Cancer, 2003. 97(12627511): p. 1464-1470.

243. Suoglu, Y., Erdamar, B., Katircioglu, O. S., Karatay, M. C., Sunay, T., Extracapsular spread in ipsilateral neck and contralateral neck metastases in laryngeal cancer, Ann Otol Rhinol Laryngol, 2002. 111(5 Pt 1): p. 447-54.

244. Tankere, F., Camproux, A., Barry, B., Guedon, C., Depondt, J., Gehanno, P., Prognostic value of lymph node involvement in oral cancers: a study of 137 cases, Laryngoscope, 2000. 110(11129021): p. 2061-2065.

245. Woolgar, J. A., Rogers, S. N., Lowe, D., Brown, J. S., Vaughan, E. D., Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread, Oral Oncol, 2003. 39(12509965): p. 130-137.

246. Tankere, F., Camproux, A., Barry, B., Guedon, C., Depondt, J., Gehanno, P., Prognostic value of lymph node involvement in oral cancers: a study of 137 cases, Laryngoscope, 2000. 110(11129021): p. 2061-2065.

247. Woolgar, J. A., Rogers, S. N., Lowe, D., Brown, J. S., Vaughan, E. D., Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread, Oral Oncol, 2003. 39(12509965): p. 130-137.

248. Suoglu, Y., Erdamar, B., Katircioglu, O. S., Karatay, M. C., Sunay, T., Extracapsular spread in ipsilateral neck and contralateral neck metastases in laryngeal cancer, Ann Otol Rhinol Laryngol, 2002. 111(5 Pt 1): p. 447-54.

249. Greenberg, Jayson S., Fowler, Robert, Gomez, Jose, Mo, Vivian, Roberts, Dianna, El Naggar, Adel K., et.al. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer, Cancer, 2003. 97(12627511): p. 1464-1470.

250. Esposito, E. D., Motta, S., Cassiano, B., Motta, G., Occult lymph node metastases in supraglottic cancers of the larynx, Otolaryngol Head Neck Surg, 2001. 124(3): p. 253-7.

251. Enepekides, D. J., Sultanem, K., Nguyen, C., Shenouda, G., Black, M. J., Rochon, L., Occult cervical metastases: immunoperoxidase analysis of the pathologically negative neck, Otolaryngol Head Neck Surg, 1999. 120(5): p. 713-717.

252. Byers, R. M., El-Naggar, A. K., Lee, Y. Y., Rao, B., Fornage, B., Terry, N. H., et.al. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?, Head Neck, 1998. 20(2): p. 138-44.

253. Ferlito, A., Partridge, M., Brennan, J., Hamakawa, H., Lymph node micrometastases in head and neck cancer: a review, Acta Otolaryngol, 2001. 121(6): p. 660-5.

254. Lindel, K., Beer, K. T., Laissue, J., Greiner, R. H., Aebersold, D. M., Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma, Cancer, 2001. 92(4): p. 805-13.

255. Buchwald, C., Lindeberg, H., Pedersen, B. L., Franzmann, M. B., Human papilloma virus and p53 expression in carcinomas associated with sinonasal papillomas: a Danish Epidemiological study 1980-1998, Laryngoscope, 2001. 111(6): p. 1104-10.

256. Friesland, S., Mellin, H., Munck-Wikland, E., Nilsson, A., Lindholm, J., Dalianis, T., et.al. Human papilloma virus (HPV) and p53 immunostaining in advanced tonsillar carcinoma--relation to radiotherapy response and survival, Anticancer Res, 2001. 21(1B): p. 529-34.

257. Gillison, M. L., Koch, W. M., Capone, R. B., Spafford, M., Westra, W. H., Wu, L., et.al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers, J Natl Cancer Inst, 2000. 92(9): p. 709-20.

258. Takes, R. P., Baatenburg De Jong, R. J., Alles, M. J., Meeuwis, C. A., Marres, H. A., Knegt, P. P., et.al. Markers for nodal metastasis in head and neck squamous cell cancer, Arch Otolaryngol Head Neck Surg, 2002. 128(5): p. 512-8.

259. Helliwell, T. R., Molecular markers of metastasis in squamous carcinomas, J Pathol, 2001. 194(3): p. 289-93.

260. Denis, F., Garaud, P., Bardet, E., Alfonsi, M., Sire, C., Germain, T., et.al. Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems, Int J Radiat Oncol Biol Phys, 2003. 55(1): p. 93-8.

261. Epstein, J. B., Lunn, R., Le, N., Stevenson-Moore, P., Periodontal attachment loss in patients after head and neck radiation therapy, Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 1998. 86(6): p. 673-7.

262. dos Santos, C. R., Goncalves Filho, J., Magrin, J., Johnson, L. F., Ferlito, A., Kowalski, L. P., Involvement of level I neck lymph nodes in advanced squamous carcinoma of the larynx, Ann Otol Rhinol Laryngol, 2001. 110(10): p. 982-4.

263. Johansen, L. V., Grau, C., Overgaard, J., Hypopharyngeal squamous cell carcinoma--treatment results in 138 consecutively admitted patients, Acta Oncol, 2000. 39(4): p. 529-36.

264. Levendag, P. C., Nowak, P. J., van der Sangen, M. J., Jansen, P. P., Eijkenboom, W. M., Planting, A. S., et.al. Local tumor control in radiation therapy of cancers in the head and neck, Am J Clin Oncol, 1996. 19(5): p. 469-477.

265. Rodgers, L. W., Jr., Stringer, S. P., Mendenhall, W. M., Parsons, J. T., Cassisi, N. J., Million, R. R., Management of squamous cell carcinoma of the floor of mouth, Head Neck, 1993. 15(1): p. 16-9.

266. Crampette, L., Garrel, R., Gardiner, Q., Maurice, N., Mondain, M., Makeieff, M., et.al. Modified subtotal laryngectomy with cricohyoidoepiglottopexy--long term results in 81 patients, Head Neck, 1999. 21(2): p. 95-103.

267. Giovanni, A., Guelfucci, B., Gras, R., Yu, P., Zanaret, M., Partial frontolateral laryngectomy with epiglottic reconstruction for management of early-stage glottic carcinoma, Laryngoscope, 2001. 111(4 Pt 1): p. 663-8.

268. Luukkaa, M., Aitasalo, K., Pulkkinen, J., Lindholm, P., Valavaara, R., Grenman, R., Neodymium YAG contact laser in the treatment of cancer of the mobile tongue, Acta Otolaryngol, 2002. 122(3): p. 318-22.

269. Edwards, D. M., Johnson, N. W., Treatment of upper aerodigestive tract cancers in England and its effect on survival, Br J Cancer, 1999. 81(2): p. 323-9.

270. Bahadur, S., Thakar, A., Mohanti, B. K., Lal, P., Results of radiotherapy with, or without, salvage surgery versus combined surgery and radiotherapy in advanced carcinoma of the hypopharynx, J Laryngol Otol, 2002. 116(1): p. 29-32.

271. Leon, X., Quer, M., Orus, C., Moran, J., Recher, K., Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced pyriform sinus carcinoma, Eur Arch Otorhinolaryngol, 2002. 259(1): p. 32-6.

272. Barzan, L., Talamini, R., Politi, D., Minatel, E., Gobitti, C., Franchin, G., Squamous cell carcinoma of the hypopharynx treated with surgery and radiotherapy, J Laryngol Otol, 2002. 116(1): p. 24-8.

273. MacKenzie, R. G., Franssen, E., Balogh, J. M., Gilbert, R. W., Birt, D., Davidson, J., Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx: a comparison limited to patients eligible for surgery, Int J Radiat Oncol Biol Phys, 2000. 47(1): p. 65-71.

274. Porter, M. J., McIvor, N. P., Morton, R. P., Hindley, A. C., Audit in the management of T3 fixed-cord laryngeal cancer, Am J Otolaryngol, 1998. 19(6): p. 360-4.

275. Staton, J., Robbins, K. T., Newman, L., Samant, S., Sebelik, M., Vieira, F., Factors predictive of poor functional outcome after chemoradiation for advanced laryngeal cancer, Otolaryngol Head Neck Surg, 2002. 127(1): p. 43-7.

276. Terrell, J. E., Fisher, S. G., Wolf, G. T., Long-term quality of life after treatment of laryngeal cancer. The Veterans Affairs Laryngeal Cancer Study Group, Arch Otolaryngol Head Neck Surg, 1998. 124(9): p. 964-71.

277. Bergqvist, M., Brodin, O., Pouzon, A., Linder, A., Hesselius, P., Blomquist, E., Radiation treatment of T1-T4 squamous cell carcinoma of the larynx: a retrospective analysis and long-term follow-up of 135 patients, Anticancer Res, 2002. 22(2B): p. 1239-42.

278. Paisley, S., Warde, P. R., O'Sullivan, B., Waldron, J., Gullane, P. J., Payne, D., et.al. Results of radiotherapy for primary subglottic squamous cell carcinoma, Int J Radiat Oncol Biol Phys, 2002. 52(5): p. 1245-50.

279. Orus, C., Leon, X., Vega, M., Quer, M., Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy, Eur Arch Otorhinolaryngol, 2000. 257(9): p. 512-6.

280. Medini, E., Medini, I., Lee, C. K., Gapany, M., Levitt, S. H., Curative radiotherapy for stage II-III squamous cell carcinoma of the glottic larynx, Am J Clin Oncol, 1998. 21(3): p. 302-5.

281. Lavertu, P., Bonafede, J. P., Adelstein, D. J., Saxton, J. P., Strome, M., Wanamaker, J. R., et.al. Comparison of surgical complications after organ-preservation therapy in patients with stage III or IV squamous cell head and neck cancer, Arch Otolaryngol Head Neck Surg, 1998. 124(4): p. 401-6.

282. Mendenhall, W. M., Amdur, R. J., Stringer, S. P., Villaret, D. B., Cassisi, N. J., Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery?, J Clin Oncol, 2000. 18(11): p. 2219-25.

283. Mendenhall, W. M., Stringer, S. P., Amdur, R. J., Hinerman, R. W., Moore-Higgs, G. J., Cassisi, N. J., Is radiation therapy a preferred alternative to surgery for squamous cell carcinoma of the base of tongue?, J Clin Oncol, 2000. 18(1): p. 35-42.

284. Tschudi, D., Stoeckli, S., Schmid, S., Quality of life after different treatment modalities for carcinoma of the oropharynx, Laryngoscope, 2003. 113(11): p. 1949-54.

285. Pfreundner, L., Hoppe, F., Willner, J., Preisler, V., Bratengeier, K., Hagen, R., et.al. Induction chemotherapy with paclitaxel and cisplatin and CT-based 3D radiotherapy in patients with advanced laryngeal and hypopharyngeal carcinomas--a possibility for organ preservation, Radiother Oncol, 2003. 68(2): p. 163-70.

286. Humphris, G. M., Freeman, R., Clarke, H. M., Risk perception of oral cancer in smokers attending primary care: a randomised controlled trial, Oral Oncol, 2004. 40(9): p. 916-24.

287. Newell, R., Ziegler, L., Stafford, N., Lewin, R. J., The information needs of head and neck cancer patients prior to surgery, Ann R Coll Surg Engl, 2004. 86(6): p. 407-10.

288. Epstein, J. B., Lunn, R., Le, N., Stevenson-Moore, P., Periodontal attachment loss in patients after head and neck radiation therapy, Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 1998. 86(6): p. 673-7.

289. Denis, F., Garaud, P., Bardet, E., Alfonsi, M., Sire, C., Germain, T., et.al. Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems, Int J Radiat Oncol Biol Phys, 2003. 55(1): p. 93-8.

290. Hicks, W. L., Loree, T. R., Garcia, R. I., Maamoun, S., Marshall, D., Orner, J. B., et.al. Squamous cell carcinoma of the floor of mouth: a 20-year review, Head Neck, 1997. 19(5): p. 400-405.

291. Kovacs, A. F., Relevance of positive margins in case of adjuvant therapy of oral cancer, Int J Oral Maxillofac Surg, 2004. 33(5): p. 447-453.

292. Loree, T. R., Strong, E. W., Significance of positive margins in oral cavity squamous carcinoma, Am J Surg, 1990. 160(4): p. 410-414.

293. O'Brien, C. J., Adams, J. R., McNeil, E. B., Taylor, P., Laniewski, P., Clifford, A., et.al. Influence of bone invasion and extent of mandibular resection on local control of cancers of the oral cavity and oropharynx, Int J Oral Maxillofac Surg, 2003. 32(5): p. 492-497.

294. Parsons, J. T., Mendenhall, W. M., Stringer, S. P., Cassisi, N. J., Million, R. R., An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity, Int J Radiat Oncol Biol Phys, 1997. 39(1): p. 137-48.

295. Sessions, D. G., Spector, G. J., Lenox, J., Parriott, S., Haughey, B., Chao, C., et.al. Analysis of treatment results for floor-of-mouth cancer, Laryngoscope, 2000. 110(10): p. 1764-1772.

296. Sutton, D. N., Brown, J. S., Rogers, S. N., Vaughan, E. D., Woolgar, J. A., The prognostic implications of the surgical margin in oral squamous cell carcinoma, Int J Oral Maxillofac Surg, 2003. 32(1): p. 30-34.

297. Abler, A., Roser, M., Weingart, D., [On the indications for and morbidity of segmental resection of the mandible for squamous cell carcinoma in the lower oral cavity], Mund-, Kiefer- und Gesichtschirurgie, 2005. 9(3): p. 137-42.

298. Brown, J. S., Kalavrezos, N., D'Souza, J., Lowe, D., Magennis, P., Woolgar, J. A., Factors that influence the method of mandibular resection in the management of oral squamous cell carcinoma, Br J Oral Maxillofac Surg, 2002. 40(4): p. 275-284.

299. Munoz Guerra, Mario Fernando, Naval Gias, Luis, Campo, Francisco Rodriguez, Perez, Jesus Sastre, Marginal and segmental mandibulectomy in patients with oral cancer: a statistical analysis of 106 cases, J Oral Maxillofac Surg, 2003. 61(11): p. 1289-1296.

300. Muscatello, L., Lenzi, R., Pellini, R., Giudice, M., Spriano, G., Marginal mandibulectomy in oral cancer surgery: A 13-year experience, European Archives of Oto-Rhino-Laryngology, 2010. 267 (5): p. 759-764.

301. Namaki, Shunsuke, Matsumoto, Mitsuhiko, Ohba, Hiroiku, Tanaka, Hiroshi, Koshikawa, Noriaki, Shinohara, Mitsuyo, Masticatory efficiency before and after surgery in oral cancer patients: comparative study of glossectomy, marginal mandibulectomy and segmental mandibulectomy, Journal of Oral Science, 2004. 46(2): p. 113-7.

302. Wolff, Diana, Hassfeld, Stefan, Hofele, Christof, Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity, J Craniomaxillofac Surg, 2004. 32(5): p. 318-323.

303. Soo, K. C., Tan, E. H., Wee, J., Lim, D., Tai, B. C., Khoo, M. L., et.al. Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison, Br J Cancer, 2005. 93(3): p. 279-86.

304. Rodgers, L. W., Jr., Stringer, S. P., Mendenhall, W. M., Parsons, J. T., Cassisi, N. J., Million, R. R., Management of squamous cell carcinoma of the floor of mouth, Head Neck, 1993. 15(1): p. 16-9.

305. Sessions, D. G., Spector, G. J., Lenox, J., Parriott, S., Haughey, B., Chao, C., et.al. Analysis of treatment results for floor-of-mouth cancer, Laryngoscope, 2000. 110(10): p. 1764-1772.

306. Lefebvre, J. L., Coche-Dequeant, B., Buisset, E., Mirabel, X., Van, J. T., Prevost, B., Management of early oral cavity cancer. Experience of Centre Oscar Lambret, Eur J Cancer B Oral Oncol, 1994. 30(3): p. 216-20.

307. Panje, W. R., Smith, B., McCabe, B. F., Epidermoid carcinoma of the floor of the mouth: surgical therapy vs combined therapy vs radiation therapy, Otolaryngol Head Neck Surg, 1980. 88(6): p. 714-720.

308. Iyer, Shridhar Ganpathi, Pradhan, S. A., Pai, P. S., Patil, S., Surgical treatment outcomes of localized squamous carcinoma of buccal mucosa, Head Neck, 2004. 26(10): p. 897-902.

309. Turner, S. L., Slevin, N. J., Gupta, N. K., Swindell, R., Radical external beam radiotherapy for 333 squamous carcinomas of the oral cavity--evaluation of late morbidity and a watch policy for the clinically negative neck, Radiother Oncol, 1996. 41(1): p. 21-9.

310. Glanzmann, C., Gratz, K. W., Radionecrosis of the mandibula: a retrospective analysis of the incidence and risk factors, Radiother Oncol, 1995. 36(2): p. 94-9100.

311. Parsons, J. T., Mendenhall, W. M., Stringer, S. P., Cassisi, N. J., Million, R. R., An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity, Int J Radiat Oncol Biol Phys, 1997. 39(1): p. 137-48.

312. Kovacs, A. F., Relevance of positive margins in case of adjuvant therapy of oral cancer, Int J Oral Maxillofac Surg, 2004. 33(5): p. 447-453.

313. O'Brien, C. J., Adams, J. R., McNeil, E. B., Taylor, P., Laniewski, P., Clifford, A., et.al. Influence of bone invasion and extent of mandibular resection on local control of cancers of the oral cavity and oropharynx, Int J Oral Maxillofac Surg, 2003. 32(5): p. 492-497.

314. Hicks, W. L., Loree, T. R., Garcia, R. I., Maamoun, S., Marshall, D., Orner, J. B., et.al. Squamous cell carcinoma of the floor of mouth: a 20-year review, Head Neck, 1997. 19(5): p. 400-405.

315. Loree, T. R., Strong, E. W., Significance of positive margins in oral cavity squamous carcinoma, Am J Surg, 1990. 160(4): p. 410-414.

316. Zelefsky, M. J., Harrison, L. B., Fass, D. E., Armstrong, J. G., Shah, J. P., Strong, E. W., Postoperative radiation therapy for squamous cell carcinomas of the oral cavity and oropharynx: impact of therapy on patients with positive surgical margins, Int J Radiat Oncol Biol Phys, 1993. 25(1): p. 17-21.

317. Brown, J. S., Kalavrezos, N., D'Souza, J., Lowe, D., Magennis, P., Woolgar, J. A., Factors that influence the method of mandibular resection in the management of oral squamous cell carcinoma, Br J Oral Maxillofac Surg, 2002. 40(4): p. 275-284.

318. Wolff, Diana, Hassfeld, Stefan, Hofele, Christof, Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity, J Craniomaxillofac Surg, 2004. 32(5): p. 318-323.

319. Munoz Guerra, Mario Fernando, Naval Gias, Luis, Campo, Francisco Rodriguez, Perez, Jesus Sastre, Marginal and segmental mandibulectomy in patients with oral cancer: a statistical analysis of 106 cases, J Oral Maxillofac Surg, 2003. 61(11): p. 1289-1296.

320. Namaki, Shunsuke, Matsumoto, Mitsuhiko, Ohba, Hiroiku, Tanaka, Hiroshi, Koshikawa, Noriaki, Shinohara, Mitsuyo, Masticatory efficiency before and after surgery in oral cancer patients: comparative study of glossectomy, marginal mandibulectomy and segmental mandibulectomy, Journal of Oral Science, 2004. 46(2): p. 113-7.

321. Rogers, Simon N., Devine, John, Lowe, Derek, Shokar, Parminder, Brown, James S., Vaugman, E. David, Longitudinal health-related quality of life after mandibular resection for oral cancer: a comparison between rim and segment, Head & Neck, 2004. 26(1): p. 54-62.

322. Byers, R. M., El-Naggar, A. K., Lee, Y. Y., Rao, B., Fornage, B., Terry, N. H., et.al. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?, Head Neck, 1998. 20(2): p. 138-44.

323. Byers, R. M., Wolf, P. F., Ballantyne, A. J., Rationale for elective modified neck dissection, Head Neck Surg, 1988. 10(3): p. 160-167.

324. Cole, I., Hughes, L., The relationship of cervical lymph node metastases to primary sites of carcinoma of the upper aerodigestive tract: a pathological study, Aust N Z J Surg, 1997. 67(12): p. 860-865.

325. Crean, St-John, Hoffman, A., Potts, John, Fardy, M. J., Reduction of occult metastatic disease by extension of the supraomohyoid neck dissection to include level IV, Head Neck, 2003. 25(12953312): p. 758-762.

326. Hao, Sheng-Po, Tsang, Ngan Ming, The role of supraomohyoid neck dissection in patients of oral cavity carcinoma(small star, filled), Oral Oncol, 2002. 38(11978555): p. 309-312.

327. Henick, D. H., Silver, C. E., Heller, K. S., Shaha, A. R., El, G. H., Wolk, D. P., Supraomohyoid neck dissection as a staging procedure for squamous cell carcinomas of the oral cavity and oropharynx, Head Neck, 1995. 17(2): p. 119-123.

328. Kligerman, J., Lima, R. A., Soares, J. R., Prado, L., Dias, F. L., Freitas, E. Q., et.al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity, Am J Surg, 1994. 168(7977957): p. 391-394.

329. McGuirt, W. F., Johnson, J. T., Myers, E. N., Rothfield, R., Wagner, R., Floor of mouth carcinoma. The management of the clinically negative neck, Arch Otolaryngol Head Neck Surg, 1995. 121(7873143): p. 278-282.

330. Nieuwenhuis, Eline J. C., Castelijns, Jonas A., Pijpers, Rik, van den Brekel, Michiel W. M., Brakenhoff, Ruud H., van der Waal, Isaac, et.al. Wait-and-see policy for the N0 neck in early-stage oral and oropharyngeal squamous cell carcinoma using ultrasonography-guided cytology: is there a role for identification of the sentinel node?, Head Neck, 2002. 24(11891961): p. 282-289.

331. O'Brien, C. J., Traynor, S. J., McNeil, E., McMahon, J. D., Chaplin, J. M., The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx, Arch Otolaryngol Head Neck Surg, 2000. 126(3): p. 360-5.

332. Shah, J. P., Candela, F. C., Poddar, A. K., The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity, Cancer, 1990. 66(1): p. 109-113.

333. Smith, G. I., O'Brien, C. J., Clark, J., Shannon, K. F., Clifford, A. R., McNeil, E. B., et.al. Management of the neck in patients with T1 and T2 cancer in the mouth, Br J Oral Maxillofac Surg, 2004. 42(6): p. 494-500.

334. Spiro, J. D., Spiro, R. H., Shah, J. P., Sessions, R. B., Strong, E. W., Critical assessment of supraomohyoid neck dissection, Am J Surg, 1988. 156(4): p. 286-289.

335. Spiro, R. H., Morgan, G. J., Strong, E. W., Shah, J. P., Supraomohyoid neck dissection, Am J Surg, 1996. 172(8988669): p. 650-653.

336. Turner, S. L., Slevin, N. J., Gupta, N. K., Swindell, R., Radical external beam radiotherapy for 333 squamous carcinomas of the oral cavity--evaluation of late morbidity and a watch policy for the clinically negative neck, Radiother Oncol, 1996. 41(1): p. 21-9.

337. Results of a prospective trial on elective modified radical classical versus supraomohyoid neck dissection in the management of oral squamous carcinoma. Brazilian Head and Neck Cancer Study Group, Am J Surg, 1998. 176(5): p. 422-7.

338. Bier, J., Radical neck dissection versus conservative neck dissection for squamous cell carcinoma of the oral cavity, Recent Results Cancer Res, 1994. 134: p. 57-62.

339. Bocca, E., Pignataro, O., Oldini, C., Cappa, C., Functional neck dissection: an evaluation and review of 843 cases, Laryngoscope, 1984. 94(7): p. 942-945.

340. Byers, R. M., Modified neck dissection. A study of 967 cases from 1970 to 1980, Am J Surg, 1985. 150(4): p. 414-21.

341. Johnson, J. T., Carcinoma of the larynx: selective approach to the management of cervical lymphatics, Ear Nose Throat J, 1994. 73(5): p. 303-5.

342. Leon, X., Quer, M., Orus, C., Sancho, F. J., Bague, S., Burgues, J., Selective dissection of levels II-III with intraoperative control of the upper and middle jugular nodes: a therapeutic option for the N0 neck, Head Neck, 2001. 23(6): p. 441-446.

343. Manni, J. J., van den Hoogen, F. J., Supraomohyoid neck dissection with frozen section biopsy as a staging procedure in the clinically node-negative neck in carcinoma of the oral cavity, Am J Surg, 1991. 162(4): p. 373-376.

344. Molinari, R., Cantu, G., Chiesa, F., Grandi, C., Retrospective comparison of conservative and radical neck dissection in laryngeal cancer, Ann Otol Rhinol Laryngol, 1980. 89(6 Pt 1): p. 578-81.

345. Spiro, R. H., Gallo, O., Shah, J. P., Selective jugular node dissection in patients with squamous carcinoma of the larynx or pharynx, Am J Surg, 1993. 166(4): p. 399-402.

346. D'Cruz, Anil K., Siddachari, Ravichand C., Walvekar, Rohan R., Pantvaidya, Gouri H., Chaukar, Devendra A., Deshpande, Mandar S., et.al. Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial, Head & Neck, 2009. 31(5): p. 618-24.

347. Dias, F. L., Kligerman, J., Matos de Sa, G., Arcuri, R. A., Freitas, E. Q., Farias, T., et.al. Elective neck dissection versus observation in stage I squamous cell carcinomas of the tongue and floor of the mouth, Otolaryngol Head Neck Surg, 2001. 125(1): p. 23-29.

348. Fakih, A. R., Rao, R. S., Borges, A. M., Patel, A. R., Elective versus therapeutic neck dissection in early carcinoma of the oral tongue, Am J Surg, 1989. 158(4): p. 309-313.

349. Grandi, C., Mingardo, M., Guzzo, M., Licitra, L., Podrecca, S., Molinari, R., Salvage surgery of cervical recurrences after neck dissection or radiotherapy, Head Neck, 1993. 15(4): p. 292-295.

350. Ho, C. M., Lam, K. H., Wei, W. I., Lau, W. F., Treatment of neck nodes in oral cancer, Surg Oncol, 1992. 1(1341238): p. 73-78.

351. Huang, Shiang-Fu, Kang, Chung-Jan, Lin, Chen-Yu, Fan, Kang-Hsing, Yen, Tzu-Chen, Wang, Hung-Ming, et.al. Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection, Cancer, 2008. 112(5): p. 1066-75.

352. Lydiatt, D. D., Robbins, K. T., Byers, R. M., Wolf, P. F., Treatment of stage I and II oral tongue cancer, Head Neck, 1993. 15(4): p. 308-312.

353. van den Brekel, M. W., Castelijns, J. A., Snow, G. B., Diagnostic evaluation of the neck, Otolaryngol Clin North Am, 1998. 31(4): p. 601-20.

354. Vandenbrouck, C., Sancho-Garnier, H., Chassagne, D., Saravane, D., Cachin, Y., Micheau, C., Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial, Cancer, 1980. 46(2): p. 386-390.

355. Wolfensberger, M., Zbaeren, P., Dulguerov, P., Muller, W., Arnoux, A., Schmid, S., Surgical treatment of early oral carcinoma-results of a prospective controlled multicenter study, Head Neck, 2001. 23(7): p. 525-530.

356. Spiro, R. H., Morgan, G. J., Strong, E. W., Shah, J. P., Supraomohyoid neck dissection, Am J Surg, 1996. 172(8988669): p. 650-653.

357. Nieuwenhuis, Eline J. C., Castelijns, Jonas A., Pijpers, Rik, van den Brekel, Michiel W. M., Brakenhoff, Ruud H., van der Waal, Isaac, et.al. Wait-and-see policy for the N0 neck in early-stage oral and oropharyngeal squamous cell carcinoma using ultrasonography-guided cytology: is there a role for identification of the sentinel node?, Head Neck, 2002. 24(11891961): p. 282-289.

358. Spiro, J. D., Spiro, R. H., Shah, J. P., Sessions, R. B., Strong, E. W., Critical assessment of supraomohyoid neck dissection, Am J Surg, 1988. 156(4): p. 286-289.

359. Smith, G. I., O'Brien, C. J., Clark, J., Shannon, K. F., Clifford, A. R., McNeil, E. B., et.al. Management of the neck in patients with T1 and T2 cancer in the mouth, Br J Oral Maxillofac Surg, 2004. 42(6): p. 494-500.

360. Crean, St-John, Hoffman, A., Potts, John, Fardy, M. J., Reduction of occult metastatic disease by extension of the supraomohyoid neck dissection to include level IV, Head Neck, 2003. 25(12953312): p. 758-762.

361. Hao, Sheng-Po, Tsang, Ngan Ming, The role of supraomohyoid neck dissection in patients of oral cavity carcinoma(small star, filled), Oral Oncol, 2002. 38(11978555): p. 309-312.

362. O'Brien, C. J., Traynor, S. J., McNeil, E., McMahon, J. D., Chaplin, J. M., The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx, Arch Otolaryngol Head Neck Surg, 2000. 126(3): p. 360-5.

363. Henick, D. H., Silver, C. E., Heller, K. S., Shaha, A. R., El, G. H., Wolk, D. P., Supraomohyoid neck dissection as a staging procedure for squamous cell carcinomas of the oral cavity and oropharynx, Head Neck, 1995. 17(2): p. 119-123.

364. Cole, I., Hughes, L., The relationship of cervical lymph node metastases to primary sites of carcinoma of the upper aerodigestive tract: a pathological study, Aust N Z J Surg, 1997. 67(12): p. 860-865.

365. McGuirt, W. F., Johnson, J. T., Myers, E. N., Rothfield, R., Wagner, R., Floor of mouth carcinoma. The management of the clinically negative neck, Arch Otolaryngol Head Neck Surg, 1995. 121(7873143): p. 278-282.

366. Kligerman, J., Lima, R. A., Soares, J. R., Prado, L., Dias, F. L., Freitas, E. Q., et.al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity, Am J Surg, 1994. 168(7977957): p. 391-394.

367. Akhtar, Shabbir, Ikram, Mubasher, Ghaffar, Shehzad, Neck involvement in early carcinoma of tongue. Is elective neck dissection warranted?, JPMA - Journal of the Pakistan Medical Association, 2007. 57(6): p. 305-7.

368. Fakih, A. R., Rao, R. S., Borges, A. M., Patel, A. R., Elective versus therapeutic neck dissection in early carcinoma of the oral tongue, Am J Surg, 1989. 158(4): p. 309-313.

369. Ho, C. M., Lam, K. H., Wei, W. I., Lau, W. F., Treatment of neck nodes in oral cancer, Surg Oncol, 1992. 1(1341238): p. 73-78.

370. Lydiatt, D. D., Robbins, K. T., Byers, R. M., Wolf, P. F., Treatment of stage I and II oral tongue cancer, Head Neck, 1993. 15(4): p. 308-312.

371. Vandenbrouck, C., Sancho-Garnier, H., Chassagne, D., Saravane, D., Cachin, Y., Micheau, C., Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial, Cancer, 1980. 46(2): p. 386-390.

372. Robbins, K. Thomas, Clayman, Garry, Levine, Paul A., Medina, Jesus, Sessions, Roy, Shaha, Ashok, et.al. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery, Arch Otolaryngol Head Neck Surg, 2002. 128(12117328): p. 751-758.

373. Robbins, K. Thomas, Clayman, Garry, Levine, Paul A., Medina, Jesus, Sessions, Roy, Shaha, Ashok, et.al. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery, Arch Otolaryngol Head Neck Surg, 2002. 128(12117328): p. 751-758.

374. Piedbois, P., Mazeron, J. J., Haddad, E., Coste, A., Martin, M., Levy, C., et.al. Stage I-II squamous cell carcinoma of the oral cavity treated by iridium-192: is elective neck dissection indicated?, Radiother Oncol, 1991. 21(2): p. 100-106.

375. Yuen, A. P., Wei, W. I., Lam, L. K., Ho, W. K., Kwong, D., Results of surgical salvage of locoregional recurrence of carcinoma of the tongue after radiotherapy failure, Ann Otol Rhinol Laryngol, 1997. 106(9): p. 779-782.

376. Weiss, M. H., Harrison, L. B., Isaacs, R. S., Use of decision analysis in planning a management strategy for the stage N0 neck, Arch Otolaryngol Head Neck Surg, 1994. 120(8018319): p. 699-702.

377. Grandi, C., Mingardo, M., Guzzo, M., Licitra, L., Podrecca, S., Molinari, R., Salvage surgery of cervical recurrences after neck dissection or radiotherapy, Head Neck, 1993. 15(4): p. 292-295.

378. D'Cruz, Anil K., Siddachari, Ravichand C., Walvekar, Rohan R., Pantvaidya, Gouri H., Chaukar, Devendra A., Deshpande, Mandar S., et.al. Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial, Head & Neck, 2009. 31(5): p. 618-24.

379. Huang, Shiang-Fu, Kang, Chung-Jan, Lin, Chen-Yu, Fan, Kang-Hsing, Yen, Tzu-Chen, Wang, Hung-Ming, et.al. Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection, Cancer, 2008. 112(5): p. 1066-75.

380. Dias, F. L., Kligerman, J., Matos de Sa, G., Arcuri, R. A., Freitas, E. Q., Farias, T., et.al. Elective neck dissection versus observation in stage I squamous cell carcinomas of the tongue and floor of the mouth, Otolaryngol Head Neck Surg, 2001. 125(1): p. 23-29.

381. Wolfensberger, M., Zbaeren, P., Dulguerov, P., Muller, W., Arnoux, A., Schmid, S., Surgical treatment of early oral carcinoma-results of a prospective controlled multicenter study, Head Neck, 2001. 23(7): p. 525-530.

382. Iype, Elizabeth Mathew, Sebastian, Paul, Mathew, Aleyamma, Balagopal, P. G., Varghese, Bipin T., Thomas, Shaji, The role of selective neck dissection (I-III) in the treatment of node negative (N0) neck in oral cancer, Oral Oncology, 2008. 44(12): p. 1134-8.

383. Yuen, Anthony Po-Wing, Ho, Chiu Ming, Chow, Tam Lin, Tang, Lap Chiu, Cheung, Wing Yung, Ng, Raymond Wai-Man, et.al. Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma, Head & Neck, 2009. 31(6): p. 765-72.

384. Beltramini, G. A., Massarelli, O., Demarchi, M., Copelli, C., Cassoni, A., Valentini, V., et.al. Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review, Oral Oncol, 2012. 48(2): p. 97-101., https://www.ncbi.nlm.nih.gov/pubmed/21993155

385. Givi, B., Eskander, A., Awad, M. I., Kong, Q., Montero, P. H., Palmer, F. L., et.al. Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate, Head Neck, 2016. 38 Suppl 1: p. E1688-94., https://www.ncbi.nlm.nih.gov/pubmed/26614119

386. Feng, Z., Li, J. N., Li, C. Z., Guo, C. B., Elective neck dissection versus observation for cN0 neck of squamous cell carcinoma primarily located in the maxillary gingiva and alveolar ridge: a retrospective study of 129 cases, Oral Surg Oral Med Oral Pathol Oral Radiol, 2013. 116(5): p. 556-61., https://www.ncbi.nlm.nih.gov/pubmed/24119520

387. Berger, M., Grau, E., Saure, D., Ristow, O., Thiele, O., Hofele, C., et.al. Occurrence of cervical lymph node metastasis of maxillary squamous cell carcinoma - A monocentric study of 171 patients, J Craniomaxillofac Surg, 2015. 43(10): p. 2195-9., https://www.ncbi.nlm.nih.gov/pubmed/26515265

388. Poeschl, P. W., Seemann, R., Czembirek, C., Russmueller, G., Sulzbacher, I., Selzer, E., et.al. Impact of elective neck dissection on regional recurrence and survival in cN0 staged oral maxillary squamous cell carcinoma, Oral Oncol, 2012. 48(2): p. 173-8., https://www.ncbi.nlm.nih.gov/pubmed/21974917

389. D'Cruz, A. K., Vaish, R., Kapre, N., Dandekar, M., Gupta, S., Hawaldar, R., et.al. Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer, N Engl J Med, 2015. 373(6): p. 521-9., https://www.ncbi.nlm.nih.gov/pubmed/26027881

390. De Silva, R. K., Siriwardena, Bsms, Samaranayaka, A., Abeyasinghe, Wamul, Tilakaratne, W. M., A model to predict nodal metastasis in patients with oral squamous cell carcinoma, PLoS One, 2018. 13(8): p. e0201755., https://www.ncbi.nlm.nih.gov/pubmed/30091996

391. Sagheb, K., Sagheb, K., Taylor, K. J., Al-Nawas, B., Walter, C., Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 25 years, Clin Oral Investig, 2014. 18(4): p. 1221-7., http://www.ncbi.nlm.nih.gov/pubmed/23934238

392. Shah, J. P., Candela, F. C., Poddar, A. K., The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity, Cancer, 1990. 66(1): p. 109-113.

393. Byers, R. M., Wolf, P. F., Ballantyne, A. J., Rationale for elective modified neck dissection, Head Neck Surg, 1988. 10(3): p. 160-167.

394. Jin, W. L., Ye, W. M., Zheng, J. W., Zhou, L., Zhu, H. G., Zhang, Z. Y., et.al. Occult cervical lymph node metastases in 100 consecutive patients with cN0 tongue cancer, Chinese Medical Journal, 2008. 121 (19): p. 1871-1874.

395. Byers, R. M., Weber, R. S., Andrews, T., McGill, D., Kare, R., Wolf, P., Frequency and therapeutic implications of "skip metastases" in the neck from squamous carcinoma of the oral tongue, Head Neck, 1997. 19(1): p. 14-9.

396. Corlette, Toby H., Cole, Ian E., Albsoul, Nader, Ayyash, Mohammad, Neck dissection of level IIb: is it really necessary?, Laryngoscope, 2005. 115(9): p. 1624-6.

397. Elsheikh, Mohamed Nasser, Mahfouz, Magdy Elsayed, Elsheikh, Ehab, Level IIb lymph nodes metastasis in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma: a molecular-based study, Laryngoscope, 2005. 115(9): p. 1636-40.

398. Lim, Young Chang, Song, Mee Hyun, Kim, Sang Cheol, Kim, Kwang Moon, Choi, Eun Chang, Preserving level IIb lymph nodes in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma, Archives of Otolaryngology -- Head & Neck Surgery, 2004. 130(9): p. 1088-91.

399. Santoro, Roberto, Franchi, Alessandro, Gallo, Oreste, Burali, Giulia, de' Campora, Enrico, Nodal metastases at level IIb during neck dissection for head and neck cancer: clinical and pathologic evaluation, Head & Neck, 2008. 30(11): p. 1483-7.

400. Kowalski, L. P., Bagietto, R., Lara, J. R., Santos, R. L., Tagawa, E. K., Santos, I. R., Factors influencing contralateral lymph node metastasis from oral carcinoma, Head Neck, 1999. 21(2): p. 104-110.

401. De Zinis, Luca Oscar Redaelli, Bolzoni, Andrea, Piazza, Cesare, Nicolai, Piero, Prevalence and localization of nodal metastases in squamous cell carcinoma of the oral cavity: role and extension of neck dissection, European Archives of Oto-Rhino-Laryngology, 2006. 263(12): p. 1131-5.

402. Johnson, J. T., Carcinoma of the larynx: selective approach to the management of cervical lymphatics, Ear Nose Throat J, 1994. 73(5): p. 303-5.

403. Manni, J. J., van den Hoogen, F. J., Supraomohyoid neck dissection with frozen section biopsy as a staging procedure in the clinically node-negative neck in carcinoma of the oral cavity, Am J Surg, 1991. 162(4): p. 373-376.

404. Leon, X., Quer, M., Orus, C., Sancho, F. J., Bague, S., Burgues, J., Selective dissection of levels II-III with intraoperative control of the upper and middle jugular nodes: a therapeutic option for the N0 neck, Head Neck, 2001. 23(6): p. 441-446.

405. Byers, R. M., Modified neck dissection. A study of 967 cases from 1970 to 1980, Am J Surg, 1985. 150(4): p. 414-21.

406. Bocca, E., Pignataro, O., Oldini, C., Cappa, C., Functional neck dissection: an evaluation and review of 843 cases, Laryngoscope, 1984. 94(7): p. 942-945.

407. Molinari, R., Cantu, G., Chiesa, F., Grandi, C., Retrospective comparison of conservative and radical neck dissection in laryngeal cancer, Ann Otol Rhinol Laryngol, 1980. 89(6 Pt 1): p. 578-81.

408. Spiro, R. H., Gallo, O., Shah, J. P., Selective jugular node dissection in patients with squamous carcinoma of the larynx or pharynx, Am J Surg, 1993. 166(4): p. 399-402.

409. Bier, J., Radical neck dissection versus conservative neck dissection for squamous cell carcinoma of the oral cavity, Recent Results Cancer Res, 1994. 134: p. 57-62.

410. Yu, Shibin, Li, Jinrong, Li, Zubing, Zhang, Wenfeng, Zhao, Jihong, Efficacy of supraomohyoid neck dissection in patients with oral squamous cell carcinoma and negative neck, American Journal of Surgery, 2006. 191(1): p. 94-9.

411. Liaw, Gwo-An, Yen, Ching-Yu, Chiang, Wei-Fan, Lee, Chin-Hai, Yang, Cheng, Chiou, Chang-Ta, et.al. Outcome of treatment with total main tumor resection and supraomohyoid neck dissection in oral squamous cell carcinoma, Journal of the Formosan Medical Association, 2006. 105(12): p. 971-7.

412. Liu, M., Wang, S. J., Yang, X., Peng, H., Diagnostic Efficacy of Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Meta-Analysis of 66 Studies, PLoS One, 2017. 12(1): p. e0170322., https://www.ncbi.nlm.nih.gov/pubmed/28107500

413. Paleri, V., Rees, G., Arullendran, P., Shoaib, T., Krishman, S., Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: a diagnostic meta-analysis, Head Neck, 2005. 27(9): p. 739-47., https://www.ncbi.nlm.nih.gov/pubmed/16047368

414. Thompson, C. F., St John, M. A., Lawson, G., Grogan, T., Elashoff, D., Mendelsohn, A. H., Diagnostic value of sentinel lymph node biopsy in head and neck cancer: a meta-analysis, Eur Arch Otorhinolaryngol, 2013. 270(7): p. 2115-22., https://www.ncbi.nlm.nih.gov/pubmed/23263205

415. Govers, T. M., Hannink, G., Merkx, M. A., Takes, R. P., Rovers, M. M., Sentinel node biopsy for squamous cell carcinoma of the oral cavity and oropharynx: a diagnostic meta-analysis, Oral Oncol, 2013. 49(8): p. 726-32., https://www.ncbi.nlm.nih.gov/pubmed/23680537

416. Lin, R., Yan, J., Liu, W., Fan, T., Tang, L., The predictive value of cervical lymph node metastasis through sentinel lymph node biopsy in patients with oral cancer: A meta-analysis, J Cancer Res Ther, 2016. 12(Supplement): p. C256-C259., https://www.ncbi.nlm.nih.gov/pubmed/28230030

417. Yamauchi, K., Kogashiwa, Y., Nakamura, T., Moro, Y., Nagafuji, H., Kohno, N., Diagnostic evaluation of sentinel lymph node biopsy in early head and neck squamous cell carcinoma: a meta-analysis, Head Neck, 2015. 37(1): p. 127-33., https://www.ncbi.nlm.nih.gov/pubmed/24478151

418. Alvarez Amezaga, J., Barbier Herrero, L., Pijoan del Barrio, J. I., Martin Rodriguez, J. C., Romo Simon, L., Genolla Subirats, J., et.al. Diagnostic efficacy of sentinel node biopsy in oral squamous cell carcinoma. Cohort study and meta-analysis, Med Oral Patol Oral Cir Bucal, 2007. 12(3): p. E235-43.

419. Alkureishi, L. W., Ross, G. L., Shoaib, T., Soutar, D. S., Robertson, A. G., Thompson, R., et.al. Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a European multicenter trial, Ann Surg Oncol, 2010. 17(9): p. 2459-64., https://www.ncbi.nlm.nih.gov/pubmed/20552410

420. Fan, S. F., Zeng, Z. Y., Peng, H. W., Guo, Z. M., Wang, S. L., Zhang, Q., Sentinel lymph node biopsy versus elective neck dissection in patients with cT1-2N0 oral tongue squamous cell carcinoma, Oral Surg Oral Med Oral Pathol Oral Radiol, 2014. 117(2): p. 186-90., https://www.ncbi.nlm.nih.gov/pubmed/24332157

421. Moya-Plana, A., Auperin, A., Guerlain, J., Gorphe, P., Casiraghi, O., Mamelle, G., et.al. Sentinel node biopsy in early oral squamous cell carcinomas: Long-term follow-up and nodal failure analysis, Oral Oncol, 2018. 82: p. 187-194., https://www.ncbi.nlm.nih.gov/pubmed/29909896

422. Schiefke, F., Akdemir, M., Weber, A., Akdemir, D., Singer, S., Frerich, B., Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection, Head Neck, 2009. 31(4): p. 503-12., https://www.ncbi.nlm.nih.gov/pubmed/19156833

423. Inoue, Hiroyuki, Nibu, Ken-Ichi, Saito, Miki, Otsuki, Naoki, Ishida, Haruhiko, Onitsuka, Tetsuro, et.al. Quality of life after neck dissection, Archives of Otolaryngology -- Head & Neck Surgery, 2006. 132(6): p. 662-6.

424. Laverick, S., Lowe, D., Brown, J. S., Vaughan, E. D., Rogers, S. N., The Impact of Neck Dissection on Health-Related Quality of Life, Archives of Otolaryngology - Head and Neck Surgery, 2004. 130 (2): p. 149-154.

425. Andersen, P. E., Shah, J. P., Cambronero, E., Spiro, R. H., The role of comprehensive neck dissection with preservation of the spinal accessory nerve in the clinically positive neck, Am J Surg, 1994. 168(7977984): p. 499-502.

426. Bocca, E., Pignataro, O., A conservation technique in radical neck dissection, Ann Otol Rhinol Laryngol, 1967. 76(5): p. 975-987.

427. Brandenburg, J. H., Lee, C. Y., The eleventh nerve in radical neck surgery, Laryngoscope, 1981. 91(11): p. 1851-1859.

428. Chu, W., Strawitz, J. G., Results in suprahyoid, modified radical, and standard radical neck dissections for metastatic squamous cell carcinoma: recurrence and survival, Am J Surg, 1978. 136(707733): p. 512-515.

429. Jesse, R. H., Ballantyne, A. J., Larson, D., Radical or modified neck dissection: a therapeutic dilemma, Am J Surg, 1978. 136(707734): p. 516-519.

430. Kohler, Hugo Fontan, Cunha, Isabella Werneck da, Kowalski, Luiz Paulo, Impact of modified radical neck dissections on the number of retrieved nodes, recurrence and survival, Revista Brasileira de Otorrinolaringologia, 2010. 76(3): p. 374-7.

431. Lingeman, R. E., Helmus, C., Stephens, R., Ulm, J., Neck dissection: radical or conservative, Ann Otol Rhinol Laryngol, 1977. 86(6 Pt 1): p. 737-44.

432. Patel, Rajan S., Clark, Jonathan R., Gao, Kan, O'Brien, Christopher J., Effectiveness of selective neck dissection in the treatment of the clinically positive neck, Head & Neck, 2008. 30(9): p. 1231-6.

433. Rapoport, Abrao, Ortellado, Daniel Kanabben, Amar, Ali, Lehn, Carlos Neutzling, Dedivitis, Rogerio Aparecido, Perez, Ricardo Salinas, et.al. Radical versus supraomohyoid neck dissection in the treatment of squamous cell carcinoma of the inferior level of the mouth, Revista Brasileira de Otorrinolaringologia, 2007. 73(5): p. 641-6.

434. Andersen, Peter E., Warren, Frank, Spiro, Jeffrey, Burningham, Alan, Wong, Richard, Wax, Mark K., et.al. Results of selective neck dissection in management of the node-positive neck, Arch Otolaryngol Head Neck Surg, 2002. 128(12365890): p. 1180-1184.

435. Chepeha, Douglas B., Hoff, Paul T., Taylor, Rodney J., Bradford, Carol R., Teknos, Theodoros N., Esclamado, Ramon M., Selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck, Laryngoscope, 2002. 112(12148849): p. 434-438.

436. Shepard, Peter M., Olson, Jordan, Harari, Paul M., Leverson, Glen, Hartig, Gregory K., Therapeutic selective neck dissection outcomes, Otolaryngology - Head & Neck Surgery, 2010. 142(5): p. 741-6.

437. Schiff, B. A., Roberts, D. B., El-Naggar, A., Garden, A. S., Myers, J. N., Selective vs modified radical neck dissection and postoperative radiotherapy vs observation in the treatment of squamous cell carcinoma of the oral tongue, Arch Otolaryngol Head Neck Surg, 2005. 131(10): p. 874-8., https://www.ncbi.nlm.nih.gov/pubmed/16230589

438. Shin, Y. S., Koh, Y. W., Kim, S. H., Choi, E. C., Selective neck dissection for clinically node-positive oral cavity squamous cell carcinoma, Yonsei Med J, 2013. 54(1): p. 139-44., https://www.ncbi.nlm.nih.gov/pubmed/23225810

439. Liao, C. T., Hsueh, C., Lee, L. Y., Lin, C. Y., Fan, K. H., Wang, H. M., et.al. Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy, Oral Oncol, 2012. 48(4): p. 329-36., https://www.ncbi.nlm.nih.gov/pubmed/22104249

440. Liang, L. Z., Liu, X. Q., Kong, Q. Y., Liao, G. Q., Selective Versus Comprehensive Neck Dissection in Patients With T1 and T2 Oral Squamous Cell Carcinoma and cN0pN(+) Neck, J Oral Maxillofac Surg, 2016. 74(6): p. 1271-6., https://www.ncbi.nlm.nih.gov/pubmed/26850871

441. Koerdt, S., Rockl, J., Rommel, N., Mucke, T., Wolff, K. D., Kesting, M. R., Lymph node management in the treatment of oral cancer: Analysis of a standardized approach, J Craniomaxillofac Surg, 2016. 44(10): p. 1737-1742., https://www.ncbi.nlm.nih.gov/pubmed/27580851

442. Brizel, David M., Prosnitz, Robert G., Hunter, Shannon, Fisher, Samuel R., Clough, Robert L., Downey, Mary Ann, et.al. Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer, Int J Radiat Oncol Biol Phys, 2004. 58(15050318): p. 1418-1423.

443. Frank, Douglas K., Hu, Kenneth S., Culliney, Bruce E., Persky, Mark S., Nussbaum, Moses, Schantz, Stimson P., et.al. Planned neck dissection after concomitant radiochemotherapy for advanced head and neck cancer, Laryngoscope, 2005. 115(15933512): p. 1015-1020.

444. Wang, S. J., Wang, M. B., Yip, H., Calcaterra, T. C., Combined radiotherapy with planned neck dissection for small head and neck cancers with advanced cervical metastases, Laryngoscope, 2000. 110(11081586): p. 1794-1797.

445. De Zinis, Luca Oscar Redaelli, Bolzoni, Andrea, Piazza, Cesare, Nicolai, Piero, Prevalence and localization of nodal metastases in squamous cell carcinoma of the oral cavity: role and extension of neck dissection, European Archives of Oto-Rhino-Laryngology, 2006. 263(12): p. 1131-5.

446. Lim, Young Chang, Song, Mee Hyun, Kim, Sang Cheol, Kim, Kwang Moon, Choi, Eun Chang, Preserving level IIb lymph nodes in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma, Archives of Otolaryngology -- Head & Neck Surgery, 2004. 130(9): p. 1088-91.

447. Ritoe, S. C., Krabbe, P. F., Jansen, M. M., Festen, J., Joosten, F. B., Kaanders, J. H., et.al. Screening for second primary lung cancer after treatment of laryngeal cancer, Laryngoscope, 2002. 112(11): p. 2002-8.

448. Koo, Bon Seok, Lim, Young Chang, Lee, Jin Seok, Choi, Eun Chang, Management of contralateral N0 neck in oral cavity squamous cell carcinoma, Head & Neck, 2006. 28(10): p. 896-901.

449. Koo, Bon Seok, Lim, Young Chang, Lee, Jin Seok, Choi, Eun Chang, Management of contralateral N0 neck in oral cavity squamous cell carcinoma, Head & Neck, 2006. 28(10): p. 896-901.

450. Jesse, R. H., Ballantyne, A. J., Larson, D., Radical or modified neck dissection: a therapeutic dilemma, Am J Surg, 1978. 136(707734): p. 516-519.

451. Lingeman, R. E., Helmus, C., Stephens, R., Ulm, J., Neck dissection: radical or conservative, Ann Otol Rhinol Laryngol, 1977. 86(6 Pt 1): p. 737-44.

452. Brandenburg, J. H., Lee, C. Y., The eleventh nerve in radical neck surgery, Laryngoscope, 1981. 91(11): p. 1851-1859.

453. Andersen, P. E., Shah, J. P., Cambronero, E., Spiro, R. H., The role of comprehensive neck dissection with preservation of the spinal accessory nerve in the clinically positive neck, Am J Surg, 1994. 168(7977984): p. 499-502.

454. Bocca, E., Pignataro, O., A conservation technique in radical neck dissection, Ann Otol Rhinol Laryngol, 1967. 76(5): p. 975-987.

455. Chu, W., Strawitz, J. G., Results in suprahyoid, modified radical, and standard radical neck dissections for metastatic squamous cell carcinoma: recurrence and survival, Am J Surg, 1978. 136(707733): p. 512-515.

456. Kohler, Hugo Fontan, Cunha, Isabella Werneck da, Kowalski, Luiz Paulo, Impact of modified radical neck dissections on the number of retrieved nodes, recurrence and survival, Revista Brasileira de Otorrinolaringologia, 2010. 76(3): p. 374-7.

457. Patel, Rajan S., Clark, Jonathan R., Gao, Kan, O'Brien, Christopher J., Effectiveness of selective neck dissection in the treatment of the clinically positive neck, Head & Neck, 2008. 30(9): p. 1231-6.

458. Rapoport, Abrao, Ortellado, Daniel Kanabben, Amar, Ali, Lehn, Carlos Neutzling, Dedivitis, Rogerio Aparecido, Perez, Ricardo Salinas, et.al. Radical versus supraomohyoid neck dissection in the treatment of squamous cell carcinoma of the inferior level of the mouth, Revista Brasileira de Otorrinolaringologia, 2007. 73(5): p. 641-6.

459. Chepeha, Douglas B., Hoff, Paul T., Taylor, Rodney J., Bradford, Carol R., Teknos, Theodoros N., Esclamado, Ramon M., Selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck, Laryngoscope, 2002. 112(12148849): p. 434-438.

460. Andersen, Peter E., Warren, Frank, Spiro, Jeffrey, Burningham, Alan, Wong, Richard, Wax, Mark K., et.al. Results of selective neck dissection in management of the node-positive neck, Arch Otolaryngol Head Neck Surg, 2002. 128(12365890): p. 1180-1184.

461. Shepard, Peter M., Olson, Jordan, Harari, Paul M., Leverson, Glen, Hartig, Gregory K., Therapeutic selective neck dissection outcomes, Otolaryngology - Head & Neck Surgery, 2010. 142(5): p. 741-6.

462. Pathak, K. A., Das, A. K., Agarwal, R., Talole, S., Deshpande, M. S., Chaturvedi, P., et.al. Selective neck dissection (I-III) for node negative and node positive necks, Oral Oncology, 2006. 42 (8): p. 837-841.

463. Vikram, B., Strong, E. W., Shah, J. P., Spiro, R., Failure in the neck following multimodality treatment for advanced head and neck cancer, Head Neck Surg, 1984. 6(3): p. 724-9.

464. Bernier, J., Domenge, C., Ozsahin, M., Matuszewska, K., Lefebvre, J. L., Greiner, R. H., et.al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer, N Engl J Med, 2004. 350(19): p. 1945-52.

465. Cooper, J. S., Pajak, T. F., Forastiere, A. A., Jacobs, J., Campbell, B. H., Saxman, S. B., et.al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck, N Engl J Med, 2004. 350(19): p. 1937-44.

466. Pagedar, N. A., Gilbert, R. W., Selective neck dissection: a review of the evidence, Oral Oncol, 2009. 45(4-5): p. 416-20., https://www.ncbi.nlm.nih.gov/pubmed/19091624

467. Agarwal, S. K., Akali, N. R., Sarin, D., Prospective analysis of 231 elective neck dissections in oral squamous cell carcinoma with node negative neck-To decide the extent of neck dissection, Auris Nasus Larynx, 2018. 45(1): p. 156-161., https://www.ncbi.nlm.nih.gov/pubmed/28662778

468. Bajwa, M. S., McMillan, R., Khattak, O., Thomas, M., Krishnan, O. P., Webster, K., Neck recurrence after level I-IV or I-III selective neck dissection in the management of the clinically N0 neck in patients with oral squamous cell carcinoma, Head Neck, 2011. 33(3): p. 403-6., https://www.ncbi.nlm.nih.gov/pubmed/20629073

469. Jones, H. B., Sykes, A., Bayman, N., Sloan, P., Swindell, R., Patel, M., et.al. The impact of lymphovascular invasion on survival in oral carcinoma, Oral Oncol, 2009. 45(1): p. 10-5., https://www.ncbi.nlm.nih.gov/pubmed/18620889

470. Matsushita, Y., Yanamoto, S., Takahashi, H., Yamada, S., Naruse, T., Sakamoto, Y., et.al. A clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma, Int J Oral Maxillofac Surg, 2015. 44(5): p. 543-8., https://www.ncbi.nlm.nih.gov/pubmed/25697063

471. Cariati, P., Cabello Serrano, A., Fernandez Solis, J., Martinez Lara, I., Distribution of cervical metastasis in tongue cancer: Are occult metastases predictable? A retrospective study of 117 oral tongue carcinomas, J Craniomaxillofac Surg, 2018. 46(1): p. 155-161., https://www.ncbi.nlm.nih.gov/pubmed/29174473

472. Argiris, Athanassios, Stenson, Kerstin M., Brockstein, Bruce E., Mittal, Bharat B., Pelzer, Harold, Kies, Merrill S., et.al. Neck dissection in the combined-modality therapy of patients with locoregionally advanced head and neck cancer, Head Neck, 2004. 26(15122662): p. 447-455.

473. Clayman, G. L., Johnson, C. J., Morrison, W., Ginsberg, L., Lippman, S. M., The role of neck dissection after chemoradiotherapy for oropharyngeal cancer with advanced nodal disease, Arch Otolaryngol Head Neck Surg, 2001. 127(11177029): p. 135-139.

474. Brizel, David M., Prosnitz, Robert G., Hunter, Shannon, Fisher, Samuel R., Clough, Robert L., Downey, Mary Ann, et.al. Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer, Int J Radiat Oncol Biol Phys, 2004. 58(15050318): p. 1418-1423.

475. Mabanta, S. R., Mendenhall, W. M., Stringer, S. P., Cassisi, N. J., Salvage treatment for neck recurrence after irradiation alone for head and neck squamous cell carcinoma with clinically positive neck nodes, Head Neck, 1999. 21(7): p. 591-594.

476. Byers, R. M., Clayman, G. L., Guillamondequi, O. M., Peters, L. J., Goepfert, H., Resection of advanced cervical metastasis prior to definitive radiotherapy for primary squamous carcinomas of the upper aerodigestive tract, Head Neck, 1992. 14(2): p. 133-138.

477. Reddy, A. N., Eisele, D. W., Forastiere, A. A., Lee, D. J., Westra, W. H., Califano, J. A., Neck dissection followed by radiotherapy or chemoradiotherapy for small primary oropharynx carcinoma with cervical metastasis, Laryngoscope, 2005. 115(7): p. 1196-200.

478. Moergel, M., Meurer, P., Ingel, K., Wendt, T. G., Al-Nawas, B., Effectiveness of postoperative radiotherapy in patients with small oral and oropharyngeal squamous cell carcinoma and concomitant ipsilateral singular cervical lymph node metastasis (pN1) : A meta-analysis, Strahlenther Onkol, 2011. 187(6): p. 337-43., https://www.ncbi.nlm.nih.gov/pubmed/21603991

479. Barry, C. P., Wong, D., Clark, J. R., Shaw, R. J., Gupta, R., Magennis, P., et.al. Postoperative radiotherapy for patients with oral squamous cell carcinoma with intermediate risk of recurrence: A case match study, Head Neck, 2017. 39(7): p. 1399-1404., https://www.ncbi.nlm.nih.gov/pubmed/28452199

480. Chen, M. M., Harris, J. P., Hara, W., Sirjani, D., Divi, V., Association of Postoperative Radiotherapy With Survival in Patients With N1 Oral Cavity and Oropharyngeal Squamous Cell Carcinoma, JAMA Otolaryngol Head Neck Surg, 2016. 142(12): p. 1224-1230., https://www.ncbi.nlm.nih.gov/pubmed/27832255

481. Unterhuber, T., Duma, M. N., Rau, A., Nieberler, M., Wolff, K. D., Kesting, M. R., Oral squamous cell carcinoma: the impact of stage-dependent therapy regimes on postoperative disease recurrence, Oral Surg Oral Med Oral Pathol Oral Radiol, 2016. 121(2): p. 133-8., https://www.ncbi.nlm.nih.gov/pubmed/26711710

482. Bhandari, K., Wang, D. C., Li, S. C., Jiang, B. H., Guo, Y. X., Koirala, U., et.al. Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis, Head Neck, 2015. 37(9): p. 1392-400., https://www.ncbi.nlm.nih.gov/pubmed/24839013

483. Eskiizmir, G., Ozgur, E., Karaca, G., Temiz, P., Yanar, N. H., Ozyurt, B. C., Stage is a prognostic factor for surgically treated patients with early-stage lip cancer for whom a 'wait and see' policy in terms of neck status has been implemented, J Laryngol Otol, 2017. 131(10): p. 889-894., https://www.ncbi.nlm.nih.gov/pubmed/28807064

484. Altinyollar, H., Bulut, H., Berberoglu, U., Is suprahyoid dissection a diagnostic operation in lower lip carcinoma?, J Exp Clin Cancer Res, 2002. 21(1): p. 29-30., https://www.ncbi.nlm.nih.gov/pubmed/12071525

485. Agostini, T., Spinelli, G., Arcuri, F., Perello, R., Metastatic Squamous Cell Carcinoma of the Lower Lip: Analysis of the 5-Year Survival Rate, Arch Craniofac Surg, 2017. 18(2): p. 105-111., https://www.ncbi.nlm.nih.gov/pubmed/28913316

486. Vanderlei, J. P., Pereira-Filho, F. J., da Cruz, F. A., de Mello, F. L., Kruschewsky Lde, S., de Freitas, L. C., et.al. Management of neck metastases in T2N0 lip squamous cell carcinoma, Am J Otolaryngol, 2013. 34(2): p. 103-6., https://www.ncbi.nlm.nih.gov/pubmed/23164629

487. Khalil, H. H., Elaffandi, A. H., Afifi, A., Alsayed, Y., Mahboub, T., El-Refaie, K. M., Sentinel lymph node biopsy (SLNB) in management of N0 stage T1-T2 lip cancer as a "same day" procedure, Oral Oncol, 2008. 44(6): p. 608-12., https://www.ncbi.nlm.nih.gov/pubmed/17936674

488. Wermker, K., Belok, F., Schipmann, S., Klein, M., Schulze, H. J., Hallermann, C., Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer, J Craniomaxillofac Surg, 2015. 43(4): p. 545-52., https://www.ncbi.nlm.nih.gov/pubmed/25753473

489. Vartanian, J. G., Carvalho, A. L., de Araujo Filho, M. J., Junior, M. H., Magrin, J., Kowalski, L. P., Predictive factors and distribution of lymph node metastasis in lip cancer patients and their implications on the treatment of the neck, Oral Oncol, 2004. 40(2): p. 223-7., https://www.ncbi.nlm.nih.gov/pubmed/14693248

490. Ozkul, Y., Songu, M., Imre, A., Tunc, E., Ozkul, Z., Arslanoglu, S., et.al. Early stage squamous cell carcinoma of the lower lip: predictive factors for recurrence, J Laryngol Otol, 2016. 130(4): p. 369-72., https://www.ncbi.nlm.nih.gov/pubmed/26860988

491. Szewczyk, M., Pazdrowski, J., Golusinski, P., Danczak-Pazdrowska, A., Marszalek, S., Golusinski, W., Analysis of selected risk factors for nodal metastases in head and neck cutaneous squamous cell carcinoma, Eur Arch Otorhinolaryngol, 2015. 272(10): p. 3007-12., https://www.ncbi.nlm.nih.gov/pubmed/25217080

492. Castelli, M. L., Pecorari, G., Succo, G., Bena, A., Andreis, M., Sartoris, A., Pectoralis major myocutaneous flap: analysis of complications in difficult patients, Eur Arch Otorhinolaryngol, 2001. 258(10): p. 542-5.

493. Suh, J. D., Sercarz, J. A., Abemayor, E., Calcaterra, T. C., Rawnsley, J. D., Alam, D., et.al. Analysis of outcome and complications in 400 cases of microvascular head and neck reconstruction, Arch Otolaryngol Head Neck Surg, 2004. 130(8): p. 962-6.

494. Villaret, D. B., Futran, N. A., The indications and outcomes in the use of osteocutaneous radial forearm free flap, Head Neck, 2003. 25(6): p. 475-81.

495. Azizzadeh, B., Yafai, S., Rawnsley, J. D., Abemayor, E., Sercarz, J. A., Calcaterra, T. C., et.al. Radial forearm free flap pharyngoesophageal reconstruction, Laryngoscope, 2001. 111(5): p. 807-10.

496. Chiarini, L., De Santis, G., Bedogni, A., Nocini, P. F., Lining the mouth floor with prelaminated fascio-mucosal free flaps: clinical experience, Microsurgery, 2002. 22(5): p. 177-86.

497. Disa, J. J., Pusic, A. L., Hidalgo, D. A., Cordeiro, P. G., Microvascular reconstruction of the hypopharynx: defect classification, treatment algorithm, and functional outcome based on 165 consecutive cases, Plast Reconstr Surg, 2003. 111(2): p. 652-60; discussion 661-3.

498. Genden, E. M., Kaufman, M. R., Katz, B., Vine, A., Urken, M. L., Tubed gastro-omental free flap for pharyngoesophageal reconstruction, Arch Otolaryngol Head Neck Surg, 2001. 127(7): p. 847-53.

499. Hayden, R. E., Deschler, D. G., Lateral thigh free flap for head and neck reconstruction, Laryngoscope, 1999. 109(9): p. 1490-4.

500. Jol, J. K., Quak, J. J., de Bree, R., Leemans, C. R., Larynx preservation surgery for advanced posterior pharyngeal wall carcinoma with free flap reconstruction: a critical appraisal, Oral Oncol, 2003. 39(6): p. 552-8.

501. Julieron, M., Germain, M. A., Schwaab, G., Marandas, P., Bourgain, J. L., Wibault, P., et.al. Reconstruction with free jejunal autograft after circumferential pharyngolaryngectomy: eighty-three cases, Ann Otol Rhinol Laryngol, 1998. 107(7): p. 581-7.

502. Makitie, A. A., Beasley, N. J., Neligan, P. C., Lipa, J., Gullane, P. J., Gilbert, R. W., Head and neck reconstruction with anterolateral thigh flap, Otolaryngol Head Neck Surg, 2003. 129(5): p. 547-55.

503. Villaret, D. B., Futran, N. A., The indications and outcomes in the use of osteocutaneous radial forearm free flap, Head Neck, 2003. 25(6): p. 475-81.

504. Chiarini, L., De Santis, G., Bedogni, A., Nocini, P. F., Lining the mouth floor with prelaminated fascio-mucosal free flaps: clinical experience, Microsurgery, 2002. 22(5): p. 177-86.

505. Azizzadeh, B., Yafai, S., Rawnsley, J. D., Abemayor, E., Sercarz, J. A., Calcaterra, T. C., et.al. Radial forearm free flap pharyngoesophageal reconstruction, Laryngoscope, 2001. 111(5): p. 807-10.

506. Jol, J. K., Quak, J. J., de Bree, R., Leemans, C. R., Larynx preservation surgery for advanced posterior pharyngeal wall carcinoma with free flap reconstruction: a critical appraisal, Oral Oncol, 2003. 39(6): p. 552-8.

507. Disa, J. J., Pusic, A. L., Hidalgo, D. A., Cordeiro, P. G., Microvascular reconstruction of the hypopharynx: defect classification, treatment algorithm, and functional outcome based on 165 consecutive cases, Plast Reconstr Surg, 2003. 111(2): p. 652-60; discussion 661-3.

508. Genden, E. M., Kaufman, M. R., Katz, B., Vine, A., Urken, M. L., Tubed gastro-omental free flap for pharyngoesophageal reconstruction, Arch Otolaryngol Head Neck Surg, 2001. 127(7): p. 847-53.

509. Hayden, R. E., Deschler, D. G., Lateral thigh free flap for head and neck reconstruction, Laryngoscope, 1999. 109(9): p. 1490-4.

510. Makitie, A. A., Beasley, N. J., Neligan, P. C., Lipa, J., Gullane, P. J., Gilbert, R. W., Head and neck reconstruction with anterolateral thigh flap, Otolaryngol Head Neck Surg, 2003. 129(5): p. 547-55.

511. Zheng, G. S., Su, Y. X., Liao, G. Q., Chen, Z. F., Wang, L., Jiao, P. F., et.al. Mandible reconstruction assisted by preoperative virtual surgical simulation, Oral Surg Oral Med Oral Pathol Oral Radiol, 2012. 113(5): p. 604-11., http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22676986

512. Zweifel, D. F., Simon, C., Hoarau, R., Pasche, P., Broome, M., Are virtual planning and guided surgery for head and neck reconstruction economically viable?, J Oral Maxillofac Surg, 2015. 73(1): p. 170-5., http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=25443385

513. Okay, D., Al Shetawi, A. H., Moubayed, S. P., Mourad, M., Buchbinder, D., Urken, M. L., Worldwide 10-Year Systematic Review of Treatment Trends in Fibula Free Flap for Mandibular Reconstruction, J Oral Maxillofac Surg, 2016. 74(12): p. 2526-2531., https://www.ncbi.nlm.nih.gov/pubmed/27400143

514. Roser, S. M., Ramachandra, S., Blair, H., Grist, W., Carlson, G. W., Christensen, A. M., et.al. The accuracy of virtual surgical planning in free fibula mandibular reconstruction: comparison of planned and final results, J Oral Maxillofac Surg, 2010. 68(11): p. 2824-32., http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20828910

515. Weitz, J., Bauer, F. J., Hapfelmeier, A., Rohleder, N. H., Wolff, K. D., Kesting, M. R., Accuracy of mandibular reconstruction by three-dimensional guided vascularised fibular free flap after segmental mandibulectomy, Br J Oral Maxillofac Surg, 2016. 54(5): p. 506-10., https://www.ncbi.nlm.nih.gov/pubmed/26898519

516. Antony, A. K., Chen, W. F., Kolokythas, A., Weimer, K. A., Cohen, M. N., Use of virtual surgery and stereolithography-guided osteotomy for mandibular reconstruction with the free fibula, Plast Reconstr Surg, 2011. 128(5): p. 1080-4., http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22030490

517. Ritschl, L. M., Mucke, T., Fichter, A., Gull, F. D., Schmid, C., Duc, J. M. P., et.al. Functional Outcome of CAD/CAM-Assisted versus Conventional Microvascular, Fibular Free Flap Reconstruction of the Mandible: A Retrospective Study of 30 Cases, J Reconstr Microsurg, 2017. 33(4): p. 281-291., https://www.ncbi.nlm.nih.gov/pubmed/28099975

518. Schepers, R. H., Raghoebar, G. M., Vissink, A., Stenekes, M. W., Kraeima, J., Roodenburg, J. L., et.al. Accuracy of fibula reconstruction using patient-specific CAD/CAM reconstruction plates and dental implants: A new modality for functional reconstruction of mandibular defects, J Craniomaxillofac Surg, 2015. 43(5): p. 649-57., https://www.ncbi.nlm.nih.gov/pubmed/25911122

519. Wilde, F., Hanken, H., Probst, F., Schramm, A., Heiland, M., Cornelius, C. P., Multicenter study on the use of patient-specific CAD/CAM reconstruction plates for mandibular reconstruction, Int J Comput Assist Radiol Surg, 2015. 10(12): p. 2035-51., https://www.ncbi.nlm.nih.gov/pubmed/25843949

520. Duncan, W., MacDougall, R. H., Kerr, G. R., Downing, D., Adverse effect of treatment gaps in the outcome of radiotherapy for laryngeal cancer, Radiother Oncol, 1996. 41(3): p. 203-7.

521. Robertson, C., Robertson, A. G., Hendry, J. H., Roberts, S. A., Slevin, N. J., Duncan, W. B., et.al. Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers, Int J Radiat Oncol Biol Phys, 1998. 40(2): p. 319-29.

522. Jacobsen, P. B., Donovan, K. A., Vadaparampil, S. T., Small, B. J., Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue, Health Psychol, 2007. 26(6): p. 660-7.

523. Cox, J. D., Stetz, J., Pajak, T. F., Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC), Int J Radiat Oncol Biol Phys, 1995. 31(5): p. 1341-6.

524. Rubin, P., Constine, L. S., Fajardo, L. F., Phillips, T. L., Wasserman, T. H., RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system, Int J Radiat Oncol Biol Phys, 1995. 31(5): p. 1041-2.

525. The National Cancer Institute, Cancer Therapy Evaluation Programme., 2006.

526. Wiernik, G., Bates, T. D., Bleehen, N. M., Brindle, J. M., Bullimore, J., Fowler, J. F., et.al. Final report of the general clinical results of the British Institute of Radiology fractionation study of 3F/wk versus 5F/wk in radiotherapy of carcinoma of the laryngo-pharynx, Br J Radiol, 1990. 63(747): p. 169-80.

527. Rezvani, M., Alcock, C. J., Fowler, J. F., Haybittle, J. L., Hopewell, J. W., Wiernik, G., Normal tissue reactions in the British Institute of Radiology Study of 3 fractions per week versus 5 fractions per week in the treatment of carcinoma of the laryngo-pharynx by radiotherapy, Br J Radiol, 1991. 64(768): p. 1122-33.

528. Gowda, R. V., Henk, J. M., Mais, K. L., Sykes, A. J., Swindell, R., Slevin, N. J., Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience, Radiother Oncol, 2003. 68(2): p. 105-11.

529. Stuschke, M., Thames, H. D., Hyperfractionated radiotherapy of human tumors: overview of the randomized clinical trials, Int J Radiat Oncol Biol Phys, 1997. 37(2): p. 259-67.

530. Cancer Care Ontario Practice Guidelines Initiative, Accelerated radiotherapy for locally advanced squamous cell carcinoma of the head and neck, revised 2002, 2002.

531. Overgaard, J., Hansen, H. S., Specht, L., Overgaard, M., Grau, C., Andersen, E., et.al. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial, Lancet, 2003. 362(9388): p. 933-40.

532. Hliniak, A., Gwiazdowska, B., Szutkowski, Z., Kraszewska, E., Kukolowicz, P., Jarzabski, A., et.al. A multicentre randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time, Radiother Oncol, 2002. 62(1): p. 1-10.

533. Horiot, J. C., Bontemps, P., van den Bogaert, W., Le Fur, R., van den Weijngaert, D., Bolla, M., et.al. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial, Radiother Oncol, 1997. 44(2): p. 111-21.

534. Bourhis, J., Overgaard, J., Audry, H., Ang, K. K., Saunders, M., Bernier, J., et.al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis, Lancet, 2006. 368(9538): p. 843-54., https://www.ncbi.nlm.nih.gov/pubmed/16950362

535. Glenny, A. M., Furness, S., Worthington, H. V., Conway, D. I., Oliver, R., Clarkson, J. E., et.al. Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy, Cochrane Database Syst Rev, 2010. p. CD006387.

536. Duncan, W., MacDougall, R. H., Kerr, G. R., Downing, D., Adverse effect of treatment gaps in the outcome of radiotherapy for laryngeal cancer, Radiother Oncol, 1996. 41(3): p. 203-7.

537. Robertson, C., Robertson, A. G., Hendry, J. H., Roberts, S. A., Slevin, N. J., Duncan, W. B., et.al. Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers, Int J Radiat Oncol Biol Phys, 1998. 40(2): p. 319-29.

538. Chao, K. S., Deasy, J. O., Markman, J., Haynie, J., Perez, C. A., Purdy, J. A., et.al. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results, Int J Radiat Oncol Biol Phys, 2001. 49(4): p. 907-16.

539. Chen, Y. J., Kuo, J. V., Ramsinghani, N. S., Al-Ghazi, M. S., Intensity-modulated radiotherapy for previously irradiated, recurrent head-and-neck cancer, Med Dosim, 2002. 27(2): p. 171-6.

540. Podd, T. J., Carton, A. T., Barrie, R., Dawes, P. K., Roberts, J. T., Stassen, L. F., et.al. Treatment of oral cancers using iridium-192 interstitial irradiation, Br J Oral Maxillofac Surg, 1994. 32(7947563): p. 207-213.

541. Shibuya, H., Hoshina, M., Takeda, M., Matsumoto, S., Suzuki, S., Okada, N., Brachytherapy for stage I & II oral tongue cancer: an analysis of past cases focusing on control and complications, Int J Radiat Oncol Biol Phys, 1993. 26(1): p. 51-58.

542. Pernot, M., Hoffstetter, S., Peiffert, D., Luporsi, E., Marchal, C., Kozminski, P., et.al. Epidermoid carcinomas of the floor of mouth treated by exclusive irradiation: statistical study of a series of 207 cases, Radiother Oncol, 1995. 35(7480819): p. 177-185.

543. Mazeron, J. J., Crook, J. M., Benck, V., Marinello, G., Martin, M., Raynal, M., et.al. Iridium 192 implantation of T1 and T2 carcinomas of the mobile tongue, Int J Radiat Oncol Biol Phys, 1990. 19(6): p. 1369-1376.

544. Matsumoto, S., Takeda, M., Shibuya, H., Suzuki, S., T1 and T2 squamous cell carcinomas of the floor of the mouth: results of brachytherapy mainly using 198Au grains, Int J Radiat Oncol Biol Phys, 1996. 34(8598360): p. 833-841.

545. Leung, T. W., Wong, V. Y., Kwan, K. H., Ng, T. Y., Wong, C. M., Tung, S. Y., et.al. High dose rate brachytherapy for early stage oral tongue cancer, Head Neck, 2002. 24(3): p. 274-81.

546. Hareyama, M., Nishio, M., Saito, A., Kagami, Y., Asano, K., Oouchi, A., et.al. Results of cesium needle interstitial implantation for carcinoma of the oral tongue, Int J Radiat Oncol Biol Phys, 1993. 25(1): p. 29-34.

547. Bachaud, J. M., Delannes, M., Allouache, N., Benchalal, M., Alzieu, C., David, J. M., et.al. Radiotherapy of stage I and II carcinomas of the mobile tongue and/or floor of the mouth, Radiother Oncol, 1994. 31(3): p. 199-206.

548. Pernot, M., Malissard, L., Hoffstetter, S., Luporsi, E., Peiffert, D., Aletti, P., et.al. The study of tumoral, radiobiological, and general health factors that influence results and complications in a series of 448 oral tongue carcinomas treated exclusively by irradiation, Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 673-9.

549. Pernot, M., Luporsi, E., Hoffstetter, S., Peiffert, D., Aletti, P., Marchal, C., et.al. Complications following definitive irradiation for cancers of the oral cavity and the oropharynx (in a series of 1134 patients), Int J Radiat Oncol Biol Phys, 1997. 37(3): p. 577-85.

550. Fujita, M., Hirokawa, Y., Kashiwado, K., Akagi, Y., Kashimoto, K., Kiriu, H., et.al. An analysis of mandibular bone complications in radiotherapy for T1 and T2 carcinoma of the oral tongue, Int J Radiat Oncol Biol Phys, 1996. 34(2): p. 333-9.

551. Mazeron, J. J., Crook, J., Martin, M., Peynegre, R., Pierquin, B., Iridium 192 implantation of squamous cell carcinomas of the oropharynx, Am J Otolaryngol, 1989. 10(5): p. 317-21.

552. Pernot, M., Malissard, L., Taghian, A., Hoffstetter, S., Luporsi, E., Forcard, J. J., et.al. Velotonsillar squamous cell carcinoma: 277 cases treated by combined external irradiation and brachytherapy--results according to extension, localization, and dose rate, Int J Radiat Oncol Biol Phys, 1992. 23(4): p. 715-23.

553. Hammerlid, E., Mercke, C., Sullivan, M., Westin, T., A prospective quality of life study of patients with oral or pharyngeal carcinoma treated with external beam irradiation with or without brachytherapy, Oral Oncol, 1997. 33(3): p. 189-96.

554. Licitra, L., Locati, L. D., Cavina, R., Garassino, I., Mattavelli, F., Pizzi, N., et.al. Primary chemotherapy followed by anterior craniofacial resection and radiotherapy for paranasal cancer, Ann Oncol, 2003. 14(3): p. 367-72.

555. Pignon, J. P., Bourhis, J., Domenge, C., Designe, L., Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer, Lancet, 2000. 355(9208): p. 949-55.

556. Bourhis J, Amand C, Pignon JP. Update of MACH-NC (Meta-Analysis of Chemotherapy in Head and Neck Cancer) database focused on concomitant chemoradiotherapy: 5505. J Clin Oncol 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition) 2004;22(14S (July 15 Supplement)).

557. Pignon, J. P., Bourhis, J., Domenge, C., Designe, L., Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer, Lancet, 2000. 355(9208): p. 949-55.

558. Pignon, J. P., le Maitre, A., Maillard, E., Bourhis, J., Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients, Radiother Oncol, 2009. 92(1): p. 4-14.

559. Blanchard, P., Baujat, B., Holostenco, V., Bourredjem, A., Baey, C., Bourhis, J., et.al. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site, Radiother Oncol, 2011. 100(1): p. 33-40.

560. Licitra, L., Locati, L. D., Cavina, R., Garassino, I., Mattavelli, F., Pizzi, N., et.al. Primary chemotherapy followed by anterior craniofacial resection and radiotherapy for paranasal cancer, Ann Oncol, 2003. 14(3): p. 367-72.

561. Budach, W., Hehr, T., Budach, V., Belka, C., Dietz, K., A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck, BMC Cancer, 2006. 6: p. 28.

562. Cancer Care Ontario Practice Guidelines Initiative, Concomitant chemotherapy and radiotherapy in squamous cell head and neck cancer (excluding nasopharynx), 2000.

563. Henk, J. M., Bishop, K., Shepherd, S. F., Treatment of head and neck cancer with CHART and nimorazole: phase II study, Radiother Oncol, 2003. 66(1): p. 65-70.

564. Olmi, P., Crispino, S., Fallai, C., Torri, V., Rossi, F., Bolner, A., et.al. Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy--a multicenter randomized trial, Int J Radiat Oncol Biol Phys, 2003. 55(1): p. 78-92.

565. Wendt, T. G., Grabenbauer, G. G., Rodel, C. M., Thiel, H. J., Aydin, H., Rohloff, R., et.al. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study, J Clin Oncol, 1998. 16(4): p. 1318-24.

566. Jeremic, B., Shibamoto, Y., Milicic, B., Nikolic, N., Dagovic, A., Aleksandrovic, J., et.al. Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: a prospective randomized trial, J Clin Oncol, 2000. 18(7): p. 1458-64.

567. Grau, C., Prakash Agarwal, J., Jabeen, K., Rab Khan, A., Abeyakoon, S., Hadjieva, T., et.al. Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial, Radiother Oncol, 2003. 67(1): p. 17-26.

568. Calais, G., Alfonsi, M., Bardet, E., Sire, C., Germain, T., Bergerot, P., et.al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma, J Natl Cancer Inst, 1999. 91(24): p. 2081-6.

569. Zakotnik, B., Smid, L., Budihna, M., Lesnicar, H., Soba, E., Furlan, L., et.al. Concomitant radiotherapy with mitomycin C and bleomycin compared with radiotherapy alone in inoperable head and neck cancer: final report, Int J Radiat Oncol Biol Phys, 1998. 41(5): p. 1121-7.

570. Fountzilas, G., Ciuleanu, E., Dafni, U., Plataniotis, G., Kalogera-Fountzila, A., Samantas, E., et.al. Concomitant radiochemotherapy vs radiotherapy alone in patients with head and neck cancer: a Hellenic Cooperative Oncology Group Phase III Study, Med Oncol, 2004. 21(2): p. 95-107.

571. El-Sayed, S., Nelson, N., Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region. A meta-analysis of prospective and randomized trials, J Clin Oncol, 1996. 14(3): p. 838-47.

572. Yu, E., Shenouda, G., Beaudet, M. P., Black, M. J., Impact of radiation therapy fraction size on local control of early glottic carcinoma, Int J Radiat Oncol Biol Phys, 1997. 37(3): p. 587-91.

573. Adelstein, D. J., Li, Y., Adams, G. L., Wagner, H., Jr., Kish, J. A., Ensley, J. F., et.al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer, J Clin Oncol, 2003. 21(1): p. 92-8.

574. Forastiere, A. A., Goepfert, H., Maor, M., Pajak, T. F., Weber, R., Morrison, W., et.al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer, N Engl J Med, 2003. 349(22): p. 2091-8.

575. Gupta, N. K., Swindell, R., Concomitant methotrexate and radiotherapy in advanced head and neck cancer: 15-year follow-up of a randomized clinical trial, Clin Oncol (R Coll Radiol), 2001. 13(5): p. 339-44.

576. Calais, G., Alfonsi, M., Bardet, E., Sire, C., Germain, T., Bergerot, P., et.al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma, J Natl Cancer Inst, 1999. 91(24): p. 2081-6.

577. Vermorken JB, Remenar E, Van Herpen C, J GL, Stewart S, Gorlia T, et al. Standard cisplatin/infusional 5-fluorouracil (PF) vs docetaxel (T) plus PF (TPF) as neoadjuvant chemotherapy for nonresectable locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): A phase III trial of the EORTC Head and Neck Cancer Group (EORTC #24971). Abstract No: 5508. Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition) 2004;22(14S July 15 Supplement).

578. Bonner, J. A., Harari, P. M., Giralt, J., Azarnia, N., Shin, D. M., Cohen, R. B., et.al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N Engl J Med, 2006. 354(6): p. 567-78.

579. Bartelink, H., Breur, K., Hart, G., Annyas, B., van Slooten, E., Snow, G., The value of postoperative radiotherapy as an adjuvant to radical neck dissection, Cancer, 1983. 52(6): p. 1008-1013.

580. Bernier, J., Domenge, C., Ozsahin, M., Matuszewska, K., Lefebvre, J. L., Greiner, R. H., et.al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer, N Engl J Med, 2004. 350(19): p. 1945-52.

581. Cooper, J. S., Pajak, T. F., Forastiere, A. A., Jacobs, J., Campbell, B. H., Saxman, S. B., et.al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck, N Engl J Med, 2004. 350(19): p. 1937-44.

582. Jesse, R. H., Fletcher, G. H., Treatment of the neck in patients with squamous cell carcinoma of the head and neck, Cancer, 1977. 39(Suppl 2): p. 868-872.

583. Lundahl, R. E., Foote, R. L., Bonner, J. A., Suman, V. J., Lewis, J. E., Kasperbauer, J. L., et.al. Combined neck dissection and postoperative radiation therapy in the management of the high-risk neck: a matched-pair analysis, Int J Radiat Oncol Biol Phys, 1998. 40(9486600): p. 529-534.

584. Peters, L. J., Goepfert, H., Ang, K. K., Byers, R. M., Maor, M. H., Guillamondegui, O., et.al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial, Int J Radiat Oncol Biol Phys, 1993. 26(1): p. 3-11.

585. Sanguineti, G., Richetti, A., Bignardi, M., Corvo, R., Gabriele, P., Sormani, M. P., et.al. Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter Phase III study, Int J Radiat Oncol Biol Phys, 2005. 61(3): p. 762-71.

586. Ang, K. K., Trotti, A., Brown, B. W., Garden, A. S., Foote, R. L., Morrison, W. H., et.al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer, Int J Radiat Oncol Biol Phys, 2001. 51(3): p. 571-8.

587. Awwad, H. K., Lotayef, M., Shouman, T., Begg, A. C., Wilson, G., Bentzen, S. M., et.al. Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation, Br J Cancer, 2002. 86(4): p. 517-23.

588. Bachaud, J. M., Cohen-Jonathan, E., Alzieu, C., David, J. M., Serrano, E., Daly-Schveitzer, N., Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial, Int J Radiat Oncol Biol Phys, 1996. 36(5): p. 999-1004.

589. Bataini, J. P., Bernier, J., Asselain, B., Lave, C., Jaulerry, C., Brunin, F., et.al. Primary radiotherapy of squamous cell carcinoma of the oropharynx and pharyngolarynx: tentative multivariate modelling system to predict the radiocurability of neck nodes, Int J Radiat Oncol Biol Phys, 1988. 14(3350718): p. 635-642.

590. Bernier, J., Cooper, J. S., Pajak, T. F., van Glabbeke, M., Bourhis, J., Forastiere, A., et.al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501), Head Neck, 2005. 27(10): p. 843-50.

591. Hareyama, M., Nishio, M., Saito, A., Kagami, Y., Asano, K., Oouchi, A., et.al. Results of cesium needle interstitial implantation for carcinoma of the oral tongue, Int J Radiat Oncol Biol Phys, 1993. 25(1): p. 29-34.

592. Lefebvre, J. L., Coche-Dequeant, B., Buisset, E., Mirabel, X., Van, J. T., Prevost, B., Management of early oral cavity cancer. Experience of Centre Oscar Lambret, Eur J Cancer B Oral Oncol, 1994. 30(3): p. 216-20.

593. Pernot, M., Hoffstetter, S., Peiffert, D., Luporsi, E., Marchal, C., Kozminski, P., et.al. Epidermoid carcinomas of the floor of mouth treated by exclusive irradiation: statistical study of a series of 207 cases, Radiother Oncol, 1995. 35(7480819): p. 177-185.

594. Pernot, M., Malissard, L., Hoffstetter, S., Luporsi, E., Peiffert, D., Aletti, P., et.al. The study of tumoral, radiobiological, and general health factors that influence results and complications in a series of 448 oral tongue carcinomas treated exclusively by irradiation, Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 673-9.

595. Chow, J. M., Levin, B. C., Krivit, J. S., Applebaum, E. L., Radiotherapy or surgery for subclinical cervical node metastases, Arch Otolaryngol Head Neck Surg, 1989. 115(8): p. 981-4.

596. Levendag, P. C., Nowak, P. J., van der Sangen, M. J., Jansen, P. P., Eijkenboom, W. M., Planting, A. S., et.al. Local tumor control in radiation therapy of cancers in the head and neck, Am J Clin Oncol, 1996. 19(5): p. 469-477.

597. Bernier, J., [Adjuvant treatment of head and neck cancers: advances and challenges], Bulletin du Cancer, 2007. 94(9): p. 823-7.

598. Huang, D. T., Johnson, C. R., Schmidt-Ullrich, R., Grimes, M., Postoperative radiotherapy in head and neck carcinoma with extracapsular lymph node extension and/or positive resection margins: a comparative study, Int J Radiat Oncol Biol Phys, 1992. 23(4): p. 737-742.

599. Vikram, B., Strong, E. W., Shah, J. P., Spiro, R., Failure in the neck following multimodality treatment for advanced head and neck cancer, Head Neck Surg, 1984. 6(3): p. 724-9.

600. Bartelink, H., Breur, K., Hart, G., Annyas, B., van Slooten, E., Snow, G., The value of postoperative radiotherapy as an adjuvant to radical neck dissection, Cancer, 1983. 52(6): p. 1008-1013.

601. Jesse, R. H., Fletcher, G. H., Treatment of the neck in patients with squamous cell carcinoma of the head and neck, Cancer, 1977. 39(Suppl 2): p. 868-872.

602. Lundahl, R. E., Foote, R. L., Bonner, J. A., Suman, V. J., Lewis, J. E., Kasperbauer, J. L., et.al. Combined neck dissection and postoperative radiation therapy in the management of the high-risk neck: a matched-pair analysis, Int J Radiat Oncol Biol Phys, 1998. 40(9486600): p. 529-534.

603. Kramer, F. J., Janssen, M., Eckardt, A., Second primary tumours in oropharyngeal squamous cell carcinoma, Clin Oral Investig, 2004. 8(2): p. 56-62.

604. Tupchong, L., Scott, C. B., Blitzer, P. H., Marcial, V. A., Lowry, L. D., Jacobs, J. R., et.al. Randomized study of preoperative versus postoperative radiation therapy in advanced head and neck carcinoma: long-term follow-up of RTOG study 73-03, Int J Radiat Oncol Biol Phys, 1991. 20(1): p. 21-8.

605. Peters, L. J., Weber, R. S., Morrison, W. H., Byers, R. M., Garden, A. S., Goepfert, H., Neck surgery in patients with primary oropharyngeal cancer treated by radiotherapy, Head Neck, 1996. 18(6): p. 552-9.

606. Snow, G. B., Annyas, A. A., van Slooten, E. A., Bartelink, H., Hart, A. A., Prognostic factors of neck node metastasis, Clin Otolaryngol Allied Sci, 1982. 7(3): p. 185-92.

607. Goffinet, D. R., Fee, W. E., Jr., Goode, R. L., Combined surgery and postoperative irradiation in the treatment of cervical lymph nodes, Arch Otolaryngol, 1984. 110(11): p. 736-8.

608. Barzan, L., Talamini, R., Analysis of prognostic factors for recurrence after neck dissection, Arch Otolaryngol Head Neck Surg, 1996. 122(12): p. 1299-302.

609. Hinerman, R. W., Mendenhall, W. M., Morris, C. G., Amdur, R. J., Werning, J. W., Villaret, D. B., Postoperative irradiation for squamous cell carcinoma of the oral cavity: 35-year experience, Head Neck, 2004. 26(11): p. 984-94.

610. Ang, K. K., Trotti, A., Brown, B. W., Garden, A. S., Foote, R. L., Morrison, W. H., et.al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer, Int J Radiat Oncol Biol Phys, 2001. 51(3): p. 571-8.

611. Close, L. G., Brown, P. M., Vuitch, M. F., Reisch, J., Schaefer, S. D., Microvascular invasion and survival in cancer of the oral cavity and oropharynx, Arch Otolaryngol Head Neck Surg, 1989. 115(11): p. 1304-9.

612. Foote, R. L., Buskirk, S. J., Stanley, R. J., Grambsch, P. M., Olsen, K. D., DeSanto, L. W., et.al. Patterns of failure after total laryngectomy for glottic carcinoma, Cancer, 1989. 64(1): p. 143-9.

613. Peters, L. J., Goepfert, H., Ang, K. K., Byers, R. M., Maor, M. H., Guillamondegui, O., et.al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial, Int J Radiat Oncol Biol Phys, 1993. 26(1): p. 3-11.

614. Sanguineti, G., Richetti, A., Bignardi, M., Corvo, R., Gabriele, P., Sormani, M. P., et.al. Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter Phase III study, Int J Radiat Oncol Biol Phys, 2005. 61(3): p. 762-71.

615. Awwad, H. K., Lotayef, M., Shouman, T., Begg, A. C., Wilson, G., Bentzen, S. M., et.al. Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation, Br J Cancer, 2002. 86(4): p. 517-23.

616. Bachaud, J. M., Cohen-Jonathan, E., Alzieu, C., David, J. M., Serrano, E., Daly-Schveitzer, N., Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial, Int J Radiat Oncol Biol Phys, 1996. 36(5): p. 999-1004.

617. Fietkau, R., Lautenschläger, C., Sauer, R., Dunst, J., Becker, A., MBaumann, M., et.al. Postoperative concurrent radiochemotherapy versus radiotherapy in high-risk SCCA of the head and neck: Results of the German phase III trial ARO 96-3, J Clin Oncol, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 5507

618. Mazeron, J. J., Crook, J. M., Benck, V., Marinello, G., Martin, M., Raynal, M., et.al. Iridium 192 implantation of T1 and T2 carcinomas of the mobile tongue, Int J Radiat Oncol Biol Phys, 1990. 19(6): p. 1369-1376.

619. Mazeron, J. J., Crook, J. M., Marinello, G., Walop, W., Pierquin, B., Prognostic factors of local outcome for T1, T2 carcinomas of oral tongue treated by iridium 192 implantation, Int J Radiat Oncol Biol Phys, 1990. 19(2): p. 281-5.

620. Cancer Care Ontario Practice Guidelines Initiative. Symptomatic treatment of radiation-induced xerostomia in head and neck cancer patients (revised). 2002. [cited 11 August 2006]. Available from url: http://www.cancercare.on.ca/pdf/pebc5-8s.pdf

621. Fisher, J., Scott, C., Scarantino, C. W., Leveque, F. G., White, R. L., Rotman, M., et.al. Phase III quality-of-life study results: impact on patients' quality of life to reducing xerostomia after radiotherapy for head-and-neck cancer--RTOG 97-09, Int J Radiat Oncol Biol Phys, 2003. 56(3): p. 832-6.

622. Tong, A. C., Leung, A. C., Cheng, J. C., Sham, J., Incidence of complicated healing and osteoradionecrosis following tooth extraction in patients receiving radiotherapy for treatment of nasopharyngeal carcinoma, Aust Dent J, 1999. 44(3): p. 187-94.

623. Epstein, J. B., Silverman, S., Jr., Paggiarino, D. A., Crockett, S., Schubert, M. M., Senzer, N. N., et.al. Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial, Cancer, 2001. 92(4): p. 875-85.

624. Prada, A., Chiesa, F., Effects of benzydamine on the oral mucositis during antineoplastic radiotherapy and/or intra-arterial chemotherapy, Int J Tissue React, 1987. 9(2): p. 115-9.

625. Kim, J. H., Chu, F. C., Lakshmi, V., Houde, R., Benzydamine HCl, a new agent for the treatment of radiation mucositis of the oropharynx, Am J Clin Oncol, 1986. 9(2): p. 132-4.

626. Epstein, J. B., Silverman, S., Jr., Paggiarino, D. A., Crockett, S., Schubert, M. M., Senzer, N. N., et.al. Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial, Cancer, 2001. 92(4): p. 875-85.

627. Sutherland, S. E., Browman, G. P., Prophylaxis of oral mucositis in irradiated head-and-neck cancer patients: a proposed classification scheme of interventions and meta-analysis of randomized controlled trials, Int J Radiat Oncol Biol Phys, 2001. 49(4): p. 917-30.

628. Cancer Care Ontario Practice Guidelines Initiative, The role of amifostine as a radioprotectant in the management of patients with squamous cell head and neck cancer. Practice Guideline Report #5-8 - 2004 Update. 2004. [cited 11 August 2006]. Available from url: http://www.cancercare.on.ca/pdf/pebc5-8f.pdf, 2004.

629. Clarkson, J. E., Worthington, H. V., Eden, O. B., Eden, T. O. B., Interventions for preventing oral mucositis for patients with cancer receiving treatment, Cochrane Database of Systematic Reviews, 2003., https://pubmed.ncbi.nlm.nih.gov/12917895/

630. Sprinzl, G. M., Galvan, O., de Vries, A., Ulmer, H., Gunkel, A. R., Lukas, P., et.al. Local application of granulocyte-macrophage colony stimulating factor (GM-CSF) for the treatment of oral mucositis, Eur J Cancer, 2001. 37(16): p. 2003-9.

631. Makkonen, T. A., Minn, H., Jekunen, A., Vilja, P., Tuominen, J., Joensuu, H., Granulocyte macrophage-colony stimulating factor (GM-CSF) and sucralfate in prevention of radiation-induced mucositis: a prospective randomized study, Int J Radiat Oncol Biol Phys, 2000. 46(3): p. 525-34.

632. Grotz, K. A., Wustenberg, P., Kohnen, R., Al-Nawas, B., Henneicke-von Zepelin, H. H., Bockisch, A., et.al. Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study, Br J Oral Maxillofac Surg, 2001. 39(1): p. 34-9.

633. Kaushal, V., Verma, K., Manocha, S., Hooda, H. S., Das, B. P., Clinical evaluation of human placental extract (placentrex) in radiation-induced oral mucositis, Int J Tissue React, 2001. 23(3): p. 105-10.

634. Kostrica, R., Rottenberg, J., Kvech, J., Betka, J., Jablonicky, P., Randomised, double-blind comparison of efficacy and tolerability of diclofenac mouthwash versus placebo in mucositis of oral cavity by radiotherapy, J Clin Res, 2002. 5(1-15): p. 1-15.

635. Saarilahti, K., Kajanti, M., Joensuu, T., Kouri, M., Joensuu, H., Comparison of granulocyte-macrophage colony-stimulating factor and sucralfate mouthwashes in the prevention of radiation-induced mucositis: a double-blind prospective randomized phase III study, Int J Radiat Oncol Biol Phys, 2002. 54(2): p. 479-85.

636. Stokman, M. A., Spijkervet, F. K., Burlage, F. R., Dijkstra, P. U., Manson, W. L., de Vries, E. G., et.al. Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial, Br J Cancer, 2003. 88(7): p. 1012-6.

637. Dodd, M. J., Miaskowski, C., Greenspan, D., MacPhail, L., Shih, A. S., Shiba, G., et.al. Radiation-induced mucositis: a randomized clinical trial of micronized sucralfate versus salt & soda mouthwashes, Cancer Invest, 2003. 21(1): p. 21-33.

638. El-Sayed, S., Nabid, A., Shelley, W., Hay, J., Balogh, J., Gelinas, M., et.al. Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scoring system, J Clin Oncol, 2002. 20(19): p. 3956-63.

639. Ertekin, M. V., Koc, M., Karslioglu, I., Sezen, O., Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study, Int J Radiat Oncol Biol Phys, 2004. 58(1): p. 167-74.

640. Trotti, A., Garden, A., Warde, P., Symonds, P., Langer, C., Redman, R., et.al. A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancy, Int J Radiat Oncol Biol Phys, 2004. 58(3): p. 674-81.

641. Worthington, H. V., Clarkson, J. E., Eden, O. B., Interventions for preventing oral candidiasis for patients with cancer receiving treatment, Cochrane Database Syst Rev, 2002. p. CD003807.

642. Cancer Care Ontario Practice Guidelines Initiative, Symptomatic treatment of radiation-induced xerostomia in head and neck cancer patients (revised), 2002.

643. Roy, I., Fortin, A., Larochelle, M., The impact of skin washing with water and soap during breast irradiation: a randomized study, Radiother Oncol, 2001. 58(3): p. 333-9.

644. Graham, P., Browne, L., Capp, A., Fox, C., Graham, J., Hollis, J., et.al. Randomized, paired comparison of No-Sting Barrier Film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation, Int J Radiat Oncol Biol Phys, 2004. 58(1): p. 241-6.

645. Williams, M. S., Burk, M., Loprinzi, C. L., Hill, M., Schomberg, P. J., Nearhood, K., et.al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity, Int J Radiat Oncol Biol Phys, 1996. 36(2): p. 345-9.

646. Wells, M., Macmillan, M., Raab, G., MacBride, S., Bell, N., MacKinnon, K., et.al. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial, Radiother Oncol, 2004. 73(2): p. 153-62.

647. Graham, P., Browne, L., Capp, A., Fox, C., Graham, J., Hollis, J., et.al. Randomized, paired comparison of No-Sting Barrier Film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation, Int J Radiat Oncol Biol Phys, 2004. 58(1): p. 241-6.

648. Agra, I. M., Carvalho, A. L., Pontes, E., Campos, O. D., Ulbrich, F. S., Magrin, J., et.al. Postoperative complications after en bloc salvage surgery for head and neck cancer, Arch Otolaryngol Head Neck Surg, 2003. 129(12): p. 1317-21.

649. Goodwin, W. J., Jr., Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means?, Laryngoscope, 2000. 110(3 Pt 2 Suppl 93): p. 1-18.

650. Emami, B., Bignardi, M., Spector, G. J., Devineni, V. R., Hederman, M. A., Reirradiation of recurrent head and neck cancers, Laryngoscope, 1987. 97(1): p. 85-8.

651. Haraf, D. J., Weichselbaum, R. R., Vokes, E. E., Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease, Ann Oncol, 1996. 7(9): p. 913-8.

652. Mazeron, J. J., Langlois, D., Glaubiger, D., Huart, J., Martin, M., Raynal, M., et.al. Salvage irradiation of oropharyngeal cancers using iridium 192 wire implants: 5-year results of 70 cases, Int J Radiat Oncol Biol Phys, 1987. 13(7): p. 957-62.

653. Peiffert, D., Pernot, M., Malissard, L., Aletti, P., Hoffstetter, S., Kozminski, P., et.al. Salvage irradiation by brachytherapy of velotonsillar squamous cell carcinoma in a previously irradiated field: results in 73 cases, Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 681-6.

654. Pomp, J., Levendag, P. C., van Putten, W. L., Reirradiation of recurrent tumors in the head and neck, Am J Clin Oncol, 1988. 11(5): p. 543-9.

655. Stevens, K. R., Jr., Britsch, A., Moss, W. T., High-dose reirradiation of head and neck cancer with curative intent, Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 687-98.

656. Goodwin, W. J., Jr., Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means?, Laryngoscope, 2000. 110(3 Pt 2 Suppl 93): p. 1-18.

657. Agra, I. M., Carvalho, A. L., Pontes, E., Campos, O. D., Ulbrich, F. S., Magrin, J., et.al. Postoperative complications after en bloc salvage surgery for head and neck cancer, Arch Otolaryngol Head Neck Surg, 2003. 129(12): p. 1317-21.

658. Loo, S. W., Geropantas, K., Beadsmoore, C., Montgomery, P. Q., Martin, W. M., Roques, T. W., Neck dissection can be avoided after sequential chemoradiotherapy and negative post-treatment positron emission tomography-computed tomography in N2 head and neck squamous cell carcinoma, Clin Oncol (R Coll Radiol), 2011. 23(8): p. 512-7., https://www.ncbi.nlm.nih.gov/pubmed/21501953

659. Mehanna, H., Wong, W. L., McConkey, C. C., Rahman, J. K., Robinson, M., Hartley, A. G., et.al. PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer, N Engl J Med, 2016. 374(15): p. 1444-54., https://www.ncbi.nlm.nih.gov/pubmed/27007578

660. Peiffert, D., Pernot, M., Malissard, L., Aletti, P., Hoffstetter, S., Kozminski, P., et.al. Salvage irradiation by brachytherapy of velotonsillar squamous cell carcinoma in a previously irradiated field: results in 73 cases, Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 681-6.

661. Mazeron, J. J., Langlois, D., Glaubiger, D., Huart, J., Martin, M., Raynal, M., et.al. Salvage irradiation of oropharyngeal cancers using iridium 192 wire implants: 5-year results of 70 cases, Int J Radiat Oncol Biol Phys, 1987. 13(7): p. 957-62.

662. Haraf, D. J., Weichselbaum, R. R., Vokes, E. E., Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease, Ann Oncol, 1996. 7(9): p. 913-8.

663. Pomp, J., Levendag, P. C., van Putten, W. L., Reirradiation of recurrent tumors in the head and neck, Am J Clin Oncol, 1988. 11(5): p. 543-9.

664. Stevens, K. R., Jr., Britsch, A., Moss, W. T., High-dose reirradiation of head and neck cancer with curative intent, Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 687-98.

665. Emami, B., Bignardi, M., Spector, G. J., Devineni, V. R., Hederman, M. A., Reirradiation of recurrent head and neck cancers, Laryngoscope, 1987. 97(1): p. 85-8.

666. Dawson, L. A., Myers, L. L., Bradford, C. R., Chepeha, D. B., Hogikyan, N. D., Teknos, T. N., et.al. Conformal re-irradiation of recurrent and new primary head-and-neck cancer, Int J Radiat Oncol Biol Phys, 2001. 50(2): p. 377-85.

667. Ohizumi, Y., Tamai, Y., Imamiya, S., Akiba, T., Complications following re-irradiation for head and neck cancer, Am J Otolaryngol, 2002. 23(4): p. 215-21.

668. Ohizumi, Y., Tamai, Y., Imamiya, S., Akiba, T., Complications following re-irradiation for head and neck cancer, Am J Otolaryngol, 2002. 23(4): p. 215-21.

669. Mohanti, B. K., Umapathy, H., Bahadur, S., Thakar, A., Pathy, S., Short course palliative radiotherapy of 20 Gy in 5 fractions for advanced and incurable head and neck cancer: AIIMS study, Radiother Oncol, 2004. 71(3): p. 275-80.

670. Citardi, M. J., Chaloupka, J. C., Son, Y. H., Ariyan, S., Sasaki, C. T., Management of carotid artery rupture by monitored endovascular therapeutic occlusion (1988-1994), Laryngoscope, 1995. 105(10): p. 1086-92.

671. Laccourreye, O., Lawson, G., Muscatello, L., Biacabe, B., Laccourreye, L., Brasnu, D., Carbon dioxide laser debulking for obstructing endolaryngeal carcinoma: a 10-year experience, Ann Otol Rhinol Laryngol, 1999. 108(5): p. 490-4.

672. Morrissey, D. D., Andersen, P. E., Nesbit, G. M., Barnwell, S. L., Everts, E. C., Cohen, J. I., Endovascular management of hemorrhage in patients with head and neck cancer, Arch Otolaryngol Head Neck Surg, 1997. 123(1): p. 15-9.

673. Paiva, M. B., Blackwell, K. E., Saxton, R. E., Calcaterra, T. C., Ward, P. H., Soudant, J., et.al. Palliative laser therapy for recurrent head and neck cancer: a Phase II clinical study, Laryngoscope, 1998. 108(9): p. 1277-83.

674. Paleri, V., Stafford, F. W., Sammut, M. S., Laser debulking in malignant upper airway obstruction, Head Neck, 2005. 27(4): p. 296-301.

675. Wilner, H. I., Lazo, A., Metes, J. J., Beil, K. A., Nowack, P., Jacobs, J., Embolization in cataclysmal hemorrhage caused by squamous cell carcinomas of the head and neck, Radiology, 1987. 163(3): p. 759-62.

676. A phase III randomised trial of cisplatinum, methotrextate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. Liverpool Head and Neck Oncology Group, Br J Cancer, 1990. 61(2): p. 311-5.

677. Clavel, M., Vermorken, J. B., Cognetti, F., Cappelaere, P., de Mulder, P. H., Schornagel, J. H., et.al. Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine (CABO) versus cisplatin and 5-fluorouracil (CF) versus cisplatin (C) in recurrent or metastatic squamous cell carcinoma of the head and neck. A phase III study of the EORTC Head and Neck Cancer Cooperative Group, Ann Oncol, 1994. 5(6): p. 521-6.

678. Forastiere, A. A., Metch, B., Schuller, D. E., Ensley, J. F., Hutchins, L. F., Triozzi, P., et.al. Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study, J Clin Oncol, 1992. 10(8): p. 1245-51.

679. Jacobs, C., Lyman, G., Velez-Garcia, E., Sridhar, K. S., Knight, W., Hochster, H., et.al. A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck, J Clin Oncol, 1992. 10(2): p. 257-63.

680. Schornagel, J. H., Verweij, J., de Mulder, P. H., Cognetti, F., Vermorken, J. B., Cappelaere, P., et.al. Randomized phase III trial of edatrexate versus methotrexate in patients with metastatic and/or recurrent squamous cell carcinoma of the head and neck: a European Organization for Research and Treatment of Cancer Head and Neck Cancer Cooperative Group study, J Clin Oncol, 1995. 13(7): p. 1649-55.

681. Bonner, J. A., Harari, P. M., Giralt, J., Azarnia, N., Shin, D. M., Cohen, R. B., et.al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N Engl J Med, 2006. 354(6): p. 567-78.

682. Jelic, S., Stamatovic, Lj, Vucicevic, S., Petrovic, Z., Kreacic, M., Babovic, N., et.al. Use of high-dose cytarabine to enhance cisplatin cytotoxicity-effects on the response and overall survival rates of advanced head and neck cancer patients, Eur J Cancer, 2002. 38(11): p. 1478-89.

683. Jacobs, C., Lyman, G., Velez-Garcia, E., Sridhar, K. S., Knight, W., Hochster, H., et.al. A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck, J Clin Oncol, 1992. 10(2): p. 257-63.

684. A phase III randomised trial of cisplatinum, methotrextate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. Liverpool Head and Neck Oncology Group, Br J Cancer, 1990. 61(2): p. 311-5.

685. Gibson, M. K., Li, Y., Murphy, B., Hussain, M. H., DeConti, R. C., Ensley, J., et.al. Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology Group, J Clin Oncol, 2005. 23(15): p. 3562-7., https://www.ncbi.nlm.nih.gov/pubmed/15908667

686. Gibson, M. K., Li, Y., Murphy, B., Hussain, M. H., DeConti, R. C., Ensley, J., et.al. Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology Group, J Clin Oncol, 2005. 23(15): p. 3562-7.

687. Forastiere, A. A., Leong, T., Rowinsky, E., Murphy, B. A., Vlock, D. R., DeConti, R. C., et.al. Phase III comparison of high-dose paclitaxel + cisplatin + granulocyte colony-stimulating factor versus low-dose paclitaxel + cisplatin in advanced head and neck cancer: Eastern Cooperative Oncology Group Study E1393, J Clin Oncol, 2001. 19(4): p. 1088-95.

688. Vermorken, J. B., Mesia, R., Rivera, F., Remenar, E., Kawecki, A., Rottey, S., et.al. Platinum-based chemotherapy plus cetuximab in head and neck cancer, N Engl J Med, 2008. 359(11): p. 1116-27., https://www.ncbi.nlm.nih.gov/pubmed/18784101

689. Vermorken, Jan Baptist, Remenar, Eva, Hitt, Ricardo, Kawecki, Andrzej, Rottey, Sylvie, Knierim, Luise, et.al. Platinum-based chemotherapy (CT) plus cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck cancer (R/M-SCCHN): 5-year follow-up data for the extreme trial, Journal of Clinical Oncology, 2014. 32(15_suppl): p. 6021-6021., https://doi.org/10.1200/jco.2014.32.15_suppl.6021

690. Mesia, R., Rivera, F., Kawecki, A., Rottey, S., Hitt, R., Kienzer, H., et.al. Quality of life of patients receiving platinum-based chemotherapy plus cetuximab first line for recurrent and/or metastatic squamous cell carcinoma of the head and neck, Ann Oncol, 2010. 21(10): p. 1967-73., https://www.ncbi.nlm.nih.gov/pubmed/20335368

691. Vermorken, J. B., Psyrri, A., Mesia, R., Peyrade, F., Beier, F., de Blas, B., et.al. Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial, Ann Oncol, 2014. 25(4): p. 801-7., https://www.ncbi.nlm.nih.gov/pubmed/24577117

692. Licitra, L., Mesia, R., Rivera, F., Remenar, E., Hitt, R., Erfan, J., et.al. Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study, Ann Oncol, 2011. 22(5): p. 1078-87., https://www.ncbi.nlm.nih.gov/pubmed/21048039

693. Ferris, R. L., Blumenschein, G., Jr., Fayette, J., Guigay, J., Colevas, A. D., Licitra, L., et.al. Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck, N Engl J Med, 2016. 375(19): p. 1856-1867., https://www.ncbi.nlm.nih.gov/pubmed/27718784

694. Ferris, R. L., Blumenschein, G., Jr., Fayette, J., Guigay, J., Colevas, A. D., Licitra, L., et.al. Nivolumab vs investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression, Oral Oncol, 2018. 81: p. 45-51., https://www.ncbi.nlm.nih.gov/pubmed/29884413

695. Gillison, M. L., Blumenschein, G., Jr., Fayette, J., Guigay, J., Colevas, A. D., Licitra, L., et.al. CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer, Oncologist, 2018. 23(9): p. 1079-1082., https://www.ncbi.nlm.nih.gov/pubmed/29866947

696. Burtness, B, Harrington, KJ, Greil, R, Soulières, D, Tahara, M, de Castro, G, et.al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study., Lancet, 2019. 394 (10212)(10212): p. 1915-1928., https://pubmed.ncbi.nlm.nih.gov/31679945/

697. Laccourreye, O., Lawson, G., Muscatello, L., Biacabe, B., Laccourreye, L., Brasnu, D., Carbon dioxide laser debulking for obstructing endolaryngeal carcinoma: a 10-year experience, Ann Otol Rhinol Laryngol, 1999. 108(5): p. 490-4.

698. Wilner, H. I., Lazo, A., Metes, J. J., Beil, K. A., Nowack, P., Jacobs, J., Embolization in cataclysmal hemorrhage caused by squamous cell carcinomas of the head and neck, Radiology, 1987. 163(3): p. 759-62.

699. Citardi, M. J., Chaloupka, J. C., Son, Y. H., Ariyan, S., Sasaki, C. T., Management of carotid artery rupture by monitored endovascular therapeutic occlusion (1988-1994), Laryngoscope, 1995. 105(10): p. 1086-92.

700. Morrissey, D. D., Andersen, P. E., Nesbit, G. M., Barnwell, S. L., Everts, E. C., Cohen, J. I., Endovascular management of hemorrhage in patients with head and neck cancer, Arch Otolaryngol Head Neck Surg, 1997. 123(1): p. 15-9.

701. Paiva, M. B., Blackwell, K. E., Saxton, R. E., Calcaterra, T. C., Ward, P. H., Soudant, J., et.al. Palliative laser therapy for recurrent head and neck cancer: a Phase II clinical study, Laryngoscope, 1998. 108(9): p. 1277-83.

702. Paleri, V., Stafford, F. W., Sammut, M. S., Laser debulking in malignant upper airway obstruction, Head Neck, 2005. 27(4): p. 296-301.

703. Boysen, M., Lovdal, O., Tausjo, J., Winther, F., The value of follow-up in patients treated for squamous cell carcinoma of the head and neck, Eur J Cancer, 1992. 28(2-3): p. 426-30.

704. Bissinger, O., Rau, A., Koerdt, S., Wolff, K. D., Kesting, M. R., Gotz, C., Evaluating tumour after care in oral squamous cell carcinoma: Insights into patients' health related quality of life, J Craniomaxillofac Surg, 2017. 45(2): p. 262-266., http://www.ncbi.nlm.nih.gov/pubmed/28049604

705. Hammerlid, E., Persson, L. O., Sullivan, M., Westin, T., Quality-of-life effects of psychosocial intervention in patients with head and neck cancer, Otolaryngol Head Neck Surg, 1999. 120(4): p. 507-16.

706. Hammerlid, E., Silander, E., Hornestam, L., Sullivan, M., Health-related quality of life three years after diagnosis of head and neck cancer--a longitudinal study, Head Neck, 2001. 23(2): p. 113-25.

707. Bjordal, K., Ahlner-Elmqvist, M., Hammerlid, E., Boysen, M., Evensen, J. F., Biorklund, A., et.al. A prospective study of quality of life in head and neck cancer patients. Part II: Longitudinal data, Laryngoscope, 2001. 111(8): p. 1440-52.

708. Smit, M., Balm, A. J., Hilgers, F. J., Tan, I. B., Pain as sign of recurrent disease in head and neck squamous cell carcinoma, Head Neck, 2001. 23(5): p. 372-5.

709. Nguyen, N. P., Sallah, S., Karlsson, U., Antoine, J. E., Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues, Cancer, 2002. 94(4): p. 1131-41.

710. Stokkel, M. P., Terhaard, C. H., Hordijk, G. J., van Rijk, P. P., The detection of local recurrent head and neck cancer with fluorine-18 fluorodeoxyglucose dual-head positron emission tomography, Eur J Nucl Med, 1999. 26(7): p. 767-73.

711. Shah, S. I., Applebaum, E. L., Lung cancer after head and neck cancer: role of chest radiography, Laryngoscope, 2000. 110(12): p. 2033-6.

712. Merkx, M. A., Boustahji, A. H., Kaanders, J. H., Joosten, F., Marres, H. A., Bruaset, I., et.al. A half-yearly chest radiograph for early detection of lung cancer following oral cancer, Int J Oral Maxillofac Surg, 2002. 31(4): p. 378-82.

713. Gottschlich, S., Maune, S., Maass, J. D., Gorogh, T., Hoffmann, M., Hoffmann-Fazel, A., et.al. Serum p53 autoantibodies in the follow-up of head and neck cancer patients, Oncology, 2000. 59(1): p. 31-5.

714. Krimmel, M., Hoffmann, J., Krimmel, C., Cornelius, C. P., Schwenzer, N., Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer, J Craniomaxillofac Surg, 1998. 26(4): p. 243-8.

715. Mayne, S. T., Cartmel, B., Baum, M., Shor-Posner, G., Fallon, B. G., Briskin, K., et.al. Randomized trial of supplemental beta-carotene to prevent second head and neck cancer, Cancer Res, 2001. 61(4): p. 1457-63.

716. Gotz, C., Drecoll, E., Straub, M., Bissinger, O., Wolff, K. D., Kolk, A., Impact of HPV infection on oral squamous cell carcinoma, Oncotarget, 2016. 7(47): p. 76704-76712., http://www.ncbi.nlm.nih.gov/pubmed/27732948

717. Brands, M. T., Brennan, P. A., Verbeek, A. L. M., Merkx, M. A. W., Geurts, S. M. E., Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature, Eur J Surg Oncol, 2018. 44(5): p. 559-565., http://www.ncbi.nlm.nih.gov/pubmed/29433990

718. Wensing, B. M., Merkx, M. A., Krabbe, P. F., Marres, H. A., Van den Hoogen, F. J., Oral squamous cell carcinoma and a clinically negative neck: the value of follow-up, Head Neck, 2011. 33(10): p. 1400-5., http://www.ncbi.nlm.nih.gov/pubmed/21928412

719. Jeon, J. H., Kim, M. G., Park, J. Y., Lee, J. H., Kim, M. J., Myoung, H., et.al. Analysis of the outcome of young age tongue squamous cell carcinoma, Maxillofac Plast Reconstr Surg, 2017. 39(1): p. 41., http://www.ncbi.nlm.nih.gov/pubmed/29302590

720. Digonnet, A., Hamoir, M., Andry, G., Haigentz, M., Jr., Takes, R. P., Silver, C. E., et.al. Post-therapeutic surveillance strategies in head and neck squamous cell carcinoma, Eur Arch Otorhinolaryngol, 2013. 270(5): p. 1569-80., http://www.ncbi.nlm.nih.gov/pubmed/22972497

721. Heiduschka, G., Virk, S. A., Palme, C. E., Ch'ng, S., Elliot, M., Gupta, R., et.al. Margin to tumor thickness ratio - A predictor of local recurrence and survival in oral squamous cell carcinoma, Oral Oncol, 2016. 55: p. 49-54., http://www.ncbi.nlm.nih.gov/pubmed/26861256

722. Low, T. H., Gao, K., Gupta, R., Clifford, A., Elliott, M., Ch'ng, S., et.al. Factors predicting poor outcomes in T1N0 oral squamous cell carcinoma: indicators for treatment intensification, ANZ J Surg, 2016. 86(5): p. 366-71., http://www.ncbi.nlm.nih.gov/pubmed/26991038

723. Flynn, C. J., Khaouam, N., Gardner, S., Higgins, K., Enepekides, D., Balogh, J., et.al. The value of periodic follow-up in the detection of recurrences after radical treatment in locally advanced head and neck cancer, Clin Oncol (R Coll Radiol), 2010. 22(10): p. 868-73., http://www.ncbi.nlm.nih.gov/pubmed/20650620

724. Lee, C. C., Huang, C. Y., Lin, Y. S., Chang, K. P., Chi, C. C., Lin, M. Y., et.al. Prognostic Performance of a New Staging Category to Improve Discrimination of Disease-Specific Survival in Nonmetastatic Oral Cancer, JAMA Otolaryngol Head Neck Surg, 2017. 143(4): p. 395-402., http://www.ncbi.nlm.nih.gov/pubmed/28125757

725. Lin, C. S., de Oliveira Santos, A. B., Silva, E. L., de Matos, L. L., Moyses, R. A., Kulcsar, M. A., et.al. Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma, Head Neck, 2017. 39(5): p. 960-964., http://www.ncbi.nlm.nih.gov/pubmed/28276113

726. Safi, A. F., Grandoch, A., Nickenig, H. J., Zoller, J. E., Kreppel, M., The importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the tongue, J Craniomaxillofac Surg, 2017. 45(7): p. 1058-1061., http://www.ncbi.nlm.nih.gov/pubmed/28529103

727. Dirven, R., Ebrahimi, A., Moeckelmann, N., Palme, C. E., Gupta, R., Clark, J., Tumor thickness versus depth of invasion - Analysis of the 8th edition American Joint Committee on Cancer Staging for oral cancer, Oral Oncol, 2017. 74: p. 30-33., http://www.ncbi.nlm.nih.gov/pubmed/29103748

728. Ermer, M. A., Kirsch, K., Bittermann, G., Fretwurst, T., Vach, K., Metzger, M. C., Recurrence rate and shift in histopathological differentiation of oral squamous cell carcinoma - A long-term retrospective study over a period of 13.5 years, J Craniomaxillofac Surg, 2015. 43(7): p. 1309-13., http://www.ncbi.nlm.nih.gov/pubmed/26116970

729. Kanatas, A., Bala, N., Lowe, D., Rogers, S. N., Outpatient follow-up appointments for patients having curative treatment for cancer of the head and neck: are the current arrangements in need of change?, Br J Oral Maxillofac Surg, 2014. 52(8): p. 681-7., http://www.ncbi.nlm.nih.gov/pubmed/25037165

730. Wolfer, S., Elstner, S., Schultze-Mosgau, S., Degree of Keratinization Is an Independent Prognostic Factor in Oral Squamous Cell Carcinoma, J Oral Maxillofac Surg, 2018. 76(2): p. 444-454., http://www.ncbi.nlm.nih.gov/pubmed/28738193

731. Hosni, A., McMullen, C., Huang, S. H., Xu, W., Su, J., Bayley, A., et.al. Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer, Radiother Oncol, 2017. 124(2): p. 225-231., http://www.ncbi.nlm.nih.gov/pubmed/28838425

732. Son, H. J., Roh, J. L., Cho, K. J., Choi, S. H., Nam, S. Y., Kim, S. Y., Nodal factors predictive of recurrence and survival in patients with oral cavity squamous cell carcinoma, Clin Otolaryngol, 2018. 43(2): p. 470-476., http://www.ncbi.nlm.nih.gov/pubmed/28981214

733. Allison, P. J., Locker, D., Feine, J. S., The relationship between dental status and health-related quality of life in upper aerodigestive tract cancer patients, Oral Oncol, 1999. 35(2): p. 138-43.

734. Granstrom, G., Radiotherapy, osseointegration and hyperbaric oxygen therapy, Periodontol 2000, 2003. 33: p. 145-62.

735. McCord, J. F., Michelinakis, G., Systematic review of the evidence supporting intra-oral maxillofacial prosthodontic care, Eur J Prosthodont Restor Dent, 2004. 12(3): p. 129-35.

736. Mericske-Stern, R., Perren, R., Raveh, J., Life table analysis and clinical evaluation of oral implants supporting prostheses after resection of malignant tumors, Int J Oral Maxillofac Implants, 1999. 14(5): p. 673-80.

737. Rosenberg, S. W., Oral complications of cancer therapies. Chronic dental complications, NCI Monogr, 1990. p. 173-8.

738. Toljanic, J. A., Heshmati, R. H., Bedard, J. F., Dental follow-up compliance in a population of irradiated head and neck cancer patients, Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 2002. 93(1): p. 35-8.

739. Granstrom, G., Radiotherapy, osseointegration and hyperbaric oxygen therapy, Periodontol 2000, 2003. 33: p. 145-62.

740. Mericske-Stern, R., Perren, R., Raveh, J., Life table analysis and clinical evaluation of oral implants supporting prostheses after resection of malignant tumors, Int J Oral Maxillofac Implants, 1999. 14(5): p. 673-80.

741. Tong, A. C., Leung, A. C., Cheng, J. C., Sham, J., Incidence of complicated healing and osteoradionecrosis following tooth extraction in patients receiving radiotherapy for treatment of nasopharyngeal carcinoma, Aust Dent J, 1999. 44(3): p. 187-94.

742. Ang, E., Black, C., Irish, J., Brown, D. H., Gullane, P., O'Sullivan, B., et.al. Reconstructive options in the treatment of osteoradionecrosis of the craniomaxillofacial skeleton, Br J Plast Surg, 2003. 56(2): p. 92-9.

743. Jereczek-Fossa, B. A., Orecchia, R., Radiotherapy-induced mandibular bone complications, Cancer Treat Rev, 2002. 28(1): p. 65-74.

744. Reuther, T., Schuster, T., Mende, U., Kubler, A., Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients--a report of a thirty year retrospective review, Int J Oral Maxillofac Surg, 2003. 32(3): p. 289-95.

745. Pasquier, D., Hoelscher, T., Schmutz, J., Dische, S., Mathieu, D., Baumann, M., et.al. Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review, Radiother Oncol, 2004. 72(1): p. 1-13.

746. Ang, E., Black, C., Irish, J., Brown, D. H., Gullane, P., O'Sullivan, B., et.al. Reconstructive options in the treatment of osteoradionecrosis of the craniomaxillofacial skeleton, Br J Plast Surg, 2003. 56(2): p. 92-9.

747. Reuther, T., Schuster, T., Mende, U., Kubler, A., Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients--a report of a thirty year retrospective review, Int J Oral Maxillofac Surg, 2003. 32(3): p. 289-95.

748. Pasquier, D., Hoelscher, T., Schmutz, J., Dische, S., Mathieu, D., Baumann, M., et.al. Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review, Radiother Oncol, 2004. 72(1): p. 1-13.

749. Annane, D., Depondt, J., Aubert, P., Villart, M., Gehanno, P., Gajdos, P., et.al. Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group, J Clin Oncol, 2004. 22(24): p. 4893-900.

750. Bennett, M. H., Feldmeier, J., Hampson, N., Smee, R., Milross, C., Hyperbaric oxygen therapy for late radiation tissue injury, Cochrane Database Syst Rev, 2005. p. CD005005.

751. Bennett, M. H., Feldmeier, J., Hampson, N., Smee, R., Milross, C., Hyperbaric oxygen therapy for late radiation tissue injury, Cochrane Database Syst Rev, 2005. p. CD005005.

752. Coulthard, P., Esposito, M., Worthington, H. V., Jokstad, A., Therapeutic use of hyperbaric oxygen for irradiated dental implant patients: a systematic review, J Dent Educ, 2003. 67(1): p. 64-8.

753. Glanzmann, C., Gratz, K. W., Radionecrosis of the mandibula: a retrospective analysis of the incidence and risk factors, Radiother Oncol, 1995. 36(2): p. 94-9100.

754. Aviv, J. E., Prospective, randomized outcome study of endoscopy versus modified barium swallow in patients with dysphagia, Laryngoscope, 2000. 110(4): p. 563-74.

755. Furia, C. L., Kowalski, L. P., Latorre, M. R., Angelis, E. C., Martins, N. M., Barros, A. P., et.al. Speech intelligibility after glossectomy and speech rehabilitation, Arch Otolaryngol Head Neck Surg, 2001. 127(7): p. 877-83.

756. Kreuzer, S. H., Schima, W., Schober, E., Pokieser, P., Kofler, G., Lechner, G., et.al. Complications after laryngeal surgery: videofluoroscopic evaluation of 120 patients, Clin Radiol, 2000. 55(10): p. 775-81.

757. Stenson, K. M., MacCracken, E., List, M., Haraf, D. J., Brockstein, B., Weichselbaum, R., et.al. Swallowing function in patients with head and neck cancer prior to treatment, Arch Otolaryngol Head Neck Surg, 2000. 126(3): p. 371-7.

758. Royal College of Speech and Language Therapists (RCSLT), Clinical Guidelines., 2004.

759. Sullivan, P., Guildford, A., Swallowing intervention in oncologySingular Publishing Group INC, 1999.

760. Eisbruch, A., Lyden, T., Bradford, C. R., Dawson, L. A., Haxer, M. J., Miller, A. E., et.al. Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer, Int J Radiat Oncol Biol Phys, 2002. 53(1): p. 23-8.

761. Nguyen, N. P., Moltz, C. C., Frank, C., Vos, P., Smith, H. J., Karlsson, U., et.al. Dysphagia following chemoradiation for locally advanced head and neck cancer, Ann Oncol, 2004. 15(3): p. 383-8.

762. Sullivan P, Guildford A. Swallowing intervention in oncology. San Diego: Singular Publishing Group INC; 1999.

763. Kreuzer, S. H., Schima, W., Schober, E., Pokieser, P., Kofler, G., Lechner, G., et.al. Complications after laryngeal surgery: videofluoroscopic evaluation of 120 patients, Clin Radiol, 2000. 55(10): p. 775-81.

764. Stenson, K. M., MacCracken, E., List, M., Haraf, D. J., Brockstein, B., Weichselbaum, R., et.al. Swallowing function in patients with head and neck cancer prior to treatment, Arch Otolaryngol Head Neck Surg, 2000. 126(3): p. 371-7.

765. Gillespie, M. B., Brodsky, M. B., Day, T. A., Lee, F. S., Martin-Harris, B., Swallowing-related quality of life after head and neck cancer treatment, Laryngoscope, 2004. 114(8): p. 1362-7.

766. Kulbersh, B. D., Rosenthal, E. L., McGrew, B. M., Duncan, R. D., McColloch, N. L., Carroll, W. R., et.al. Pretreatment, preoperative swallowing exercises may improve dysphagia quality of life, Laryngoscope, 2006. 116(6): p. 883-6.

767. NHS Quality Improvement Scotland, Clinical Standards: food, fluid and nutritional care in hospitals, 2003.

768. Beaver, M. E., Myers, J. N., Griffenberg, L., Waugh, K., Percutaneous fluoroscopic gastrostomy tube placement in patients with head and neck cancer, Arch Otolaryngol Head Neck Surg, 1998. 124(10): p. 1141-4.

769. Deurloo, E. E., Schultze Kool, L. J., Kroger, R., van Coevorden, F., Balm, A. J., Percutaneous radiological gastrostomy in patients with head and neck cancer, European Journal of Surgical Oncology, 2001. 27(1): p. 94-7.

770. Lee, J. H., Machtay, M., Unger, L. D., Weinstein, G. S., Weber, R. S., Chalian, A. A., et.al. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck, Arch Otolaryngol Head Neck Surg, 1998. 124(8): p. 871-5.

771. Mekhail, T. M., Adelstein, D. J., Rybicki, L. A., Larto, M. A., Saxton, J. P., Lavertu, P., Enteral nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube?, Cancer, 2001. 91(9): p. 1785-90.

772. Schweinfurth, J. M., Boger, G. N., Feustel, P. J., Preoperative risk assessment for gastrostomy tube placement in head and neck cancer patients, Head Neck, 2001. 23(5): p. 376-82.

773. Deurloo, E. E., Schultze Kool, L. J., Kroger, R., van Coevorden, F., Balm, A. J., Percutaneous radiological gastrostomy in patients with head and neck cancer, European Journal of Surgical Oncology, 2001. 27(1): p. 94-7.

774. Beaver, M. E., Myers, J. N., Griffenberg, L., Waugh, K., Percutaneous fluoroscopic gastrostomy tube placement in patients with head and neck cancer, Arch Otolaryngol Head Neck Surg, 1998. 124(10): p. 1141-4.

775. Chawla, S., Mohanti, B. K., Rakshak, M., Saxena, S., Rath, G. K., Bahadur, S., Temporal assessment of quality of life of head and neck cancer patients receiving radical radiotherapy, Qual Life Res, 1999. 8(1-2): p. 73-8.

776. Gritz, E. R., Carmack, C. L., de Moor, C., Coscarelli, A., Schacherer, C. W., Meyers, E. G., et.al. First year after head and neck cancer: quality of life, J Clin Oncol, 1999. 17(1): p. 352-60.

777. Zwahlen, R. A., Dannemann, C., Gratz, K. W., Studer, G., Zwahlen, D., Moergeli, H., et.al. Quality of life and psychiatric morbidity in patients successfully treated for oral cavity squamous cell cancer and their wives, J Oral Maxillofac Surg, 2008. 66(6): p. 1125-32.

778. Singer, S., Brown, A., Einenkel, J., Hauss, J., Hinz, A., Klein, A., et.al. Identifying tumor patients' depression, Support Care Cancer, 2011. 19(11): p. 1697-703.

779. Spelten, E. R., Sprangers, M. A., Verbeek, J. H., Factors reported to influence the return to work of cancer survivors: a literature review, Psychooncology, 2002. 11(2): p. 124-31.

780. Relic, A., Mazemda, P., Arens, C., Koller, M., Glanz, H., Investigating quality of life and coping resources after laryngectomy, Eur Arch Otorhinolaryngol, 2001. 258(10): p. 514-7.

781. Fielding, David, Agnew, Julienne, Wright, David, Hodge, Robert, Autofluorescence improves pretreatment mucosal assessment in head and neck cancer patients, Otolaryngology - Head & Neck Surgery, 2010. 142(3 Suppl 1): p. S20-6.

782. Royal College of Pathologists. Standards and Datasets for Reporting Cancers: Datasets for histopathology reports on head and neck carcinomas and salivary neoplasms. 2nd Edition. London: The Royal College of Pathologists; 2005. [cited 11 August 2006]. Available from url: http://www.rcpath.org/resources/pdf/HeadNeckDatasetJun05.pdf

783. Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005. (WHO Classification of Tumours)

784. Board of the Faculty of Clinical Oncology. Guidelines for the Management of the Unscheduled Interruption or Prolongation of a Radical Course of Radiotherapy. 2nd Edition. London: The Royal College of Radiologists; 2002. [cited 11 August 2006]. Available from url: http://www.rcr.ac.uk/docs/oncology/pdf/gaps.pdf