Leitlinienprogramm OnkologieLungenkarzinom

22. Literaturverzeichnis – Lungenkarzinom

Version 5.1 · Juli 2026 · AWMF 020-007OL
Leitlinienprogramm Onkologie · Deutsche Krebsgesellschaft · Deutsche Krebshilfe · AWMF

1. Barta, J. A., Powell, C. A., Wisnivesky, J. P., Global Epidemiology of Lung Cancer, Ann Glob Health, 2019. 85(1):, https://www.ncbi.nlm.nih.gov/pubmed/30741509

2. Wild, Christopher, Weiderpass, Elisabete, Stewart, Bernard W., International Agency for Research on Cancer, World Health Organization, World cancer report cancer research for cancer preventionIARC Press, 2020., https://pubmed.ncbi.nlm.nih.gov/39432694/

3. Barnes, Benjamin, Kraywinkel, Klaus, Nowossadeck, Enno, Schönfeld, Ina, Starker, Anne, Wienecke, Antje, et.al. Bericht zum Krebsgeschehen in Deutschland 2016Robert Koch-Institut, 2016.

4. Hoebel, J, Kroll, LE, Fiebig, J, Lampert, T, Katalinic, A, Barnes, B, et.al. Socioeconomic Inequalities in Total and Site-Specific Cancer Incidence in Germany: A Population-Based Registry Study., Front Oncol, 2018. 8 (): p. 402., https://pubmed.ncbi.nlm.nih.gov/30319967/

5. Sidorchuk, A, Agardh, EE, Aremu, O, Hallqvist, J, Allebeck, P, Moradi, T, Socioeconomic differences in lung cancer incidence: a systematic review and meta-analysis., Cancer Causes Control, 2009. 20 (4)(4): p. 459-71., https://pubmed.ncbi.nlm.nih.gov/19184626/

6. Geyer, S, Social inequalities in the incidence and case fatality of cancers of the lung, the stomach, the bowels, and the breast., Cancer Causes Control, 2008. 19 (9)(9): p. 965-74., https://pubmed.ncbi.nlm.nih.gov/18431680/

7. Kuznetsov, L., Mielck, A., [Regional concentration of social disadvantage and of risks for lung cancer and colon cancer: systematic review and recommendations for research], Gesundheitswesen, 2012. 74(6): p. e42-51.

8. Van der Heyden, J. H., Schaap, M. M., Kunst, A. E., Esnaola, S., Borrell, C., Cox, B., et.al. Socioeconomic inequalities in lung cancer mortality in 16 European populations, Lung Cancer, 2009. 63(3): p. 322-30., https://www.ncbi.nlm.nih.gov/pubmed/18656277

9. Menvielle, G, Boshuizen, H, Kunst, AE, Dalton, SO, Vineis, P, Bergmann, MM, et.al. The role of smoking and diet in explaining educational inequalities in lung cancer incidence., J Natl Cancer Inst, 2009. 101 (5)(5): p. 321-30., https://pubmed.ncbi.nlm.nih.gov/19244178/

10. Hastert, TA, Ruterbusch, JJ, Beresford, SA, Sheppard, L, White, E, Contribution of health behaviors to the association between area-level socioeconomic status and cancer mortality., Soc Sci Med, 2016. 148 (): p. 52-8., https://pubmed.ncbi.nlm.nih.gov/26650930/

11. Finke, I, Behrens, G, Weisser, L, Brenner, H, Jansen, L, Socioeconomic Differences and Lung Cancer Survival-Systematic Review and Meta-Analysis., Front Oncol, 2018. 8 (): p. 536., https://pubmed.ncbi.nlm.nih.gov/30542641/

12. Finke, I, Behrens, G, Maier, W, Schwettmann, L, Pritzkuleit, R, Holleczek, B, et.al. Small-area analysis on socioeconomic inequalities in cancer survival for 25 cancer sites in Germany., Int J Cancer, 2021. 149 (3)(3): p. 561-572., https://pubmed.ncbi.nlm.nih.gov/33751564/

13. Wong, MCS, Lao, XQ, Ho, KF, Goggins, WB, Tse, SLA, Incidence and mortality of lung cancer: global trends and association with socioeconomic status., Sci Rep, 2017. 7 (1)(1): p. 14300., https://pubmed.ncbi.nlm.nih.gov/29085026/

14. Alberg, A. J., Samet, J. M., Epidemiology of lung cancer, in Encyclopedia of human nutrition, Sadler, M. J.Caballero, B. and Strain, J., Editors. 2005, Academic Press: London. p. 272-284., https://www.ncbi.nlm.nih.gov/pubmed/12527563

15. Wichmann H. E.; Molik B., Pott F., Jöckel K. H., Luftverunreinigungen und Lungenkrebs - Ergebnisse einer PilotstudieErich Schmidt Verlag, Umweltbundesamt, 1991.

16. Erdmann, Friederike, Spix, Claudia, Katalinic, Alexander, Christ, Monika, Folkerts, Juliane, Hansmann, Jutta, et.al. Krebs in Deutschland für 2017/2018,Robert Koch-Institut, 2021., http://dx.doi.org/10.25646/8353

17. Nowak D., Huber R. M., Berufliche Risikofaktoren, Berufskrankheit, arbeitsmedizinische Begutachtung, in Manual der Tumore der Lunge und des Mediastinums, 2020 (12. Auflage), Tumorzentrum München: München.

18. International Agency for Research on Cancer, Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 83 Tobacco Smoke and Involuntary Smoking. Lyon, World Health Organization, 2004., https://www.ncbi.nlm.nih.gov/pubmed/15285078

19. Gredner, T, Mons, U, Niedermaier, T, Brenner, H, Soerjomataram, I, Impact of tobacco control policies implementation on future lung cancer incidence in Europe: An international, population-based modeling study., Lancet Reg Health Eur, 2021. 4 (): p. 100074., https://pubmed.ncbi.nlm.nih.gov/34029359/

20. Zeeb, H, Loss, J, Starke, D, Altgeld, T, Moebus, S, Geffert, K, et.al. Public health in Germany: structures, dynamics, and ways forward., Lancet Public Health, 2025. 10 (4)(4): p. e333-e342., https://pubmed.ncbi.nlm.nih.gov/40049182/

21. United States Public Health Service Office of the Surgeon, General, National Center for Chronic Disease, Prevention, Health Promotion Office on, Smoking, Health, Publications and Reports of the Surgeon General, in Smoking Cessation: A Report of the Surgeon General, 2020, US Department of Health and Human Services. ():, https://pubmed.ncbi.nlm.nih.gov/32255575/

22. Toll, BA, Brandon, TH, Gritz, ER, Warren, GW, Herbst, RS, Assessing tobacco use by cancer patients and facilitating cessation: an American Association for Cancer Research policy statement., Clin Cancer Res, 2013. 19 (8)(8): p. 1941-8., https://pubmed.ncbi.nlm.nih.gov/23570694/

23. Gritz, ER, Talluri, R, Fokom Domgue, J, Tami-Maury, I, Shete, S, Smoking Behaviors in Survivors of Smoking-Related and Non-Smoking-Related Cancers., JAMA Netw Open, 2020. 3 (7)(7): p. e209072., https://pubmed.ncbi.nlm.nih.gov/32614423/

24. Caini, S, Del Riccio, M, Vettori, V, Scotti, V, Martinoli, C, Raimondi, S, et.al. Quitting Smoking At or Around Diagnosis Improves the Overall Survival of Lung Cancer Patients: A Systematic Review and Meta-Analysis., J Thorac Oncol, 2022. 17 (5)(5): p. 623-636., https://pubmed.ncbi.nlm.nih.gov/34995798/

25. Klosterhalfen, S, Viechtbauer, W, Kotz, D, Disposable e-cigarettes: Prevalence of use in Germany from 2016 to 2023 and associated user characteristics., Addiction, 2025. 120 (3)(3): p. 557-567., https://pubmed.ncbi.nlm.nih.gov/39488907/

26. Sahu, R, Shah, K, Malviya, R, Paliwal, D, Sagar, S, Singh, S, et.al. E-Cigarettes and Associated Health Risks: An Update on Cancer Potential., Adv Respir Med, 2023. 91 (6)(6): p. 516-531., https://pubmed.ncbi.nlm.nih.gov/37987300/

27. Sanner, T, Grimsrud, TK, Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review., Front Oncol, 2015. 5 (): p. 196., https://pubmed.ncbi.nlm.nih.gov/26380225/

28. Kundu, A, Sachdeva, K, Feore, A, Sanchez, S, Sutton, M, Seth, S, et.al. Evidence update on the cancer risk of vaping e-cigarettes: A systematic review., Tob Induc Dis, 2025. 23 ():, https://pubmed.ncbi.nlm.nih.gov/39877383/

29. National Academies of Sciences, Engineering, Medicine, Public Health Consequences of E-CigarettesThe National Academies Press, 2018. p. 774., https://nap.nationalacademies.org/catalog/24952/public-health-consequences-of-e-cigarettes

30. Bracken-Clarke, D, Kapoor, D, Baird, AM, Buchanan, PJ, Gately, K, Cuffe, S, et.al. Vaping and lung cancer - A review of current data and recommendations., Lung Cancer, 2021. 153 (): p. 11-20., https://pubmed.ncbi.nlm.nih.gov/33429159/

31. Goldberg Scott, S, Feigelson, HS, Powers, JD, Clennin, MN, Lyons, JA, Gray, MT, et.al. Demographic, Clinical, and Behavioral Factors Associated With Electronic Nicotine Delivery Systems Use in a Large Cohort in the United States., Tob Use Insights, 2023. 16 (): p. 1179173X221134855., https://pubmed.ncbi.nlm.nih.gov/36636234/

32. Bittoni, MA, Carbone, DP, Harris, RE, Vaping, Smoking and Lung Cancer Risk., J Oncol Res Ther, 2024. 9 (3)(3):, https://pubmed.ncbi.nlm.nih.gov/39210964/

33. Zeiher, Johannes, Starker, Anne, Lampert, Thomas, Kuntz, Benjamin, Passivrauchbelastung bei Erwachsenen in DeutschlandRobert Koch-Institut, 2018. p. 72 - 80.

34. Carreras, G, Lugo, A, Gallus, S, Cortini, B, Fernández, E, López, MJ, et.al. Burden of disease attributable to second-hand smoke exposure: A systematic review., Prev Med, 2019. 129 (): p. 105833., https://pubmed.ncbi.nlm.nih.gov/31505203/

35. Raupach, T, Schäfer, K, Konstantinides, S, Andreas, S, Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm., Eur Heart J, 2006. 27 (4)(4): p. 386-92., https://pubmed.ncbi.nlm.nih.gov/16230308/

36. Bridevaux, PO, Cornuz, J, Gaspoz, JM, Burnand, B, Ackermann-Liebrich, U, Schindler, C, et.al. Secondhand smoke and health-related quality of life in never smokers: results from the SAPALDIA cohort study 2., Arch Intern Med, 2007. 167 (22)(22): p. 2516-23., https://pubmed.ncbi.nlm.nih.gov/18071176/

37. Possenti, I, Romelli, M, Carreras, G, Biffi, A, Bagnardi, V, Specchia, C, et.al. Association between second-hand smoke exposure and lung cancer risk in never-smokers: a systematic review and meta-analysis., Eur Respir Rev, 2024. 33 (174)(174):, https://pubmed.ncbi.nlm.nih.gov/39537242/

38. Elkefi, S, Zeinoun, G, Tounsi, A, Bruzzese, JM, Lelutiu-Weinberger, C, Matthews, AK, Second-Hand Smoke Exposure and Risk of Lung Cancer Among Nonsmokers in the United States: A Systematic Review and Meta-Analysis., Int J Environ Res Public Health, 2025. 22 (4)(4):, https://pubmed.ncbi.nlm.nih.gov/40283819/

39. Frazer, K, Callinan, JE, McHugh, J, van Baarsel, S, Clarke, A, Doherty, K, et.al. Legislative smoking bans for reducing harms from secondhand smoke exposure, smoking prevalence and tobacco consumption., Cochrane Database Syst Rev, 2016. 2 (2)(2): p. CD005992., https://pubmed.ncbi.nlm.nih.gov/26842828/

40. Pesch B., Jöckel K. H., Wichmann H. E., Luftverunreinigung und Lungenkrebs, Biometrie und Epidemiologie in der Medizin und Biologie, 1995. p. 134-153.

41. Who, Air Quality Guidelines Global Update 2005, WHO Copenhagen, 2006.

42. Agency, Us-Epa Environmental Protection, Air Quality Criteria for Particulate Matter, EPA/600/P-99/D02bF, Washington 2004, 2004.

43. Berg, CD, Schiller, JH, Boffetta, P, Cai, J, Connolly, C, Kerpel-Fronius, A, et.al. Air Pollution and Lung Cancer: A Review by International Association for the Study of Lung Cancer Early Detection and Screening Committee., J Thorac Oncol, 2023. 18 (10)(10): p. 1277-1289., https://pubmed.ncbi.nlm.nih.gov/37277094/

44. Darby, S., Hill, D., Auvinen, A., Barros-Dios, J. M., Baysson, H., Bochicchio, F., et.al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies, BMJ, 2005. 330(7485): p. 223., https://www.ncbi.nlm.nih.gov/pubmed/15613366

45. Bundeswehr, Informationen zur Strahlung von Radargeräten der Bundeswehr und der ehemaligen Nationalen Volksarmee sowie zu möglichen Ansprüchen in diesem Zusammenhang, 2008.

46. Bruske-Hohlfeld, I., Mohner, M., Ahrens, W., Pohlabeln, H., Heinrich, J., Kreuzer, M., et.al. Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany, Am.J Ind.Med, 1999. 36(4): p. 405-414., https://pubmed.ncbi.nlm.nih.gov/10470005/

47. Bhatia, R., Lopipero, P., Smith, A. H., Diesel exhaust exposure and lung cancer, Epidemiology, 1998. 9(1): p. 84-91., https://www.ncbi.nlm.nih.gov/pubmed/9430274

48. Benbrahim-Tallaa, L., Baan, R. A., Grosse, Y., Lauby-Secretan, B., El Ghissassi, F., Bouvard, V., et.al. Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes, Lancet Oncol, 2012. 13(7): p. 663-4., https://www.ncbi.nlm.nih.gov/pubmed/22946126

49. Romero Starke, K, Bolm-Audorff, U, Reissig, D, Seidler, A, Dose-response-relationship between occupational exposure to diesel engine emissions and lung cancer risk: A systematic review and meta-analysis., Int J Hyg Environ Health, 2024. 256 (): p. 114299., https://pubmed.ncbi.nlm.nih.gov/38194821/

50. International Agency for Research on Cancer, Monographs Volume 2: Some Inorganic and Organometallic Compounds. Lyon, World Health Organization, 1973.

51. International Agency for Research on, Cancer, Monographs Volume 14: Asbestos. Lyon, World Health Organization, 1977.

52. (HVBG), Hauptverband der gewerblichen Berufsgenossenschaften, Faserjahre. Berufsgenossenschaftliche Hinweise zur Ermittlung der kumulativen Asbestfaserstaubdosis am Arbeitsplatz (Faserjahre) und Bearbeitungshinweise zur Berufskrankheit Nr. 4101 Lungenkrebs oder Kehlkopfkrebs, in BK-Report 1/2007, 2007: St. Augustin.

53. Drechsel-Schlund, C., Butz, M., Haupt, B., et al., Asbestverursachte Berufskrankheiten in Deutschland - Entstehung und Prognose. Hauptverband der gewerblichen Berufsgenossenschaften (HVBG), http://www.hvbg.de/d/pages/statist/brosch/asbest1.pdf, 2003.

54. International Agency for Research on, Cancer, Monographs Volume 33: Polynuclear Aromatic Hydrocarbons, Part 2, Carbon Blacks, Mineral Oils (Lubricant Base Oils and Derived Products) and Some Nitroarenes. Lyon, World Health Organization, 1983.

55. International Agency for Research on, Cancer, Monographs Volume 34: Polynuclear Aromatic Compounds Part 3, Industrial Exposures in Aluminium Production, Coal Gasification, Coke Production, and Iron and Steel Founding. Lyon, World Health Organization, 1984.

56. International Agency for Research on, Cancer, Monographs Volume 35: Polynuclear Aromatic Compounds Part 4, Bitumens, Coal-tars and Derived Products, Shale-oils and Soots. Lyon, World Health Organization, 1985.

57. International Agency for Research on, Cancer, Monographs Volume 68: Silica. Lyon, World Health Organization, 1997.

58. International Agency for Research on, Cancer, Monographs Volume 23: Some Metals and Metallic Compounds. Lyon, World Health Organization, 1980.

59. Wichmann H. E., Positive gesundheitliche Auswirkungen des Einsatzes von Partikelfiltern bei Dieselfahrzeugen - Risikoabschätzung für die Mortalität in Deutschland, Umweltmedizin in Forschung und Praxis, 2004. 9: p. 85-99.

60. Figueroa, W. G., Raszkowski, R. W., Lung cancer in chloromethyl methylether workers, N Engl J Med, 1973. 288: p. 1096-1097., https://www.ncbi.nlm.nih.gov/pubmed/4727973

61. Thiess, A. M., Hey, W., Zeller, H., Zur Toxikologie von Dichlordimethyl„ther - Verdacht auf kanzerogene Wirkung auch beim Menschen, Zbl Arbeitsmed Arbeitsschutz, 1973. 23: p. 97-102., https://pubmed.ncbi.nlm.nih.gov/4751658/

62. International Agency for Research on, Cancer, Monographs Volume 58: Beryllium, Cadmium, Mercury, and Exposures in the Glass Manufacturing Industry. Lyon, World Health Organization, 1993.

63. International Agency for Research on Cancer, Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 86, Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide. Lyon, World Health Organization, 2006., https://pubmed.ncbi.nlm.nih.gov/16906675/

64. GBIA, Berufsgenossenschaftliches Institut für Arbeitsschutz (BGIA), 2006.

65. Ang, L, Chan, CPY, Yau, WP, Seow, WJ, Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis., Lung Cancer, 2020. 148 (): p. 129-137., https://pubmed.ncbi.nlm.nih.gov/32892102/

66. Caini, S, Gorini, G, Del Riccio, M, Saieva, C, Carreras, G, Bonomo, P, et.al. Upgrading your best chances: postdiagnosis smoking cessation boosts life expectancy of patients with cancer - a systematic review and meta-analysis., Tob Control, 2025. ():, https://pubmed.ncbi.nlm.nih.gov/39762052/

67. Lai, H, Liu, Q, Ye, Q, Liang, Z, Long, Z, Hu, Y, et.al. Impact of smoking cessation duration on lung cancer mortality: A systematic review and meta-analysis., Crit Rev Oncol Hematol, 2024. 196 (): p. 104323., https://pubmed.ncbi.nlm.nih.gov/38462148/

68. Allbright, K, Villandre, J, Crotty Alexander, LE, Zhang, M, Benam, KH, Evankovich, J, et.al. The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes., Eur Respir J, 2024. 63 (6)(6):, https://pubmed.ncbi.nlm.nih.gov/38609098/

69. Mohapatra, S, Tiwari, A, Kandala, A, Winayak, R, Ghose, A, Das, R, et.al. The risk of lung cancer from vaping or e-cigarette usage: a systematic review., ESMO Open, 2025. 10 (12)(12): p. 105910., https://pubmed.ncbi.nlm.nih.gov/41259896/

70. A clinical practice guideline for treating tobacco use and dependence: 2008 update. A U.S. Public Health Service report., Am J Prev Med, 2008. 35 (2)(2): p. 158-76., https://pubmed.ncbi.nlm.nih.gov/18617085/

71. Gemine, RE, Davies, GR, Lanyon, K, Rees, SE, Campbell, I, Lewis, KE, Quitting smoking improves two-year survival after a diagnosis of non-small cell lung cancer., Lung Cancer, 2023. 186 (): p. 107388., https://pubmed.ncbi.nlm.nih.gov/37820539/

72. Cinciripini, PM, Kypriotakis, G, Blalock, JA, Karam-Hage, M, Beneventi, DM, Robinson, JD, et.al. Survival Outcomes of an Early Intervention Smoking Cessation Treatment After a Cancer Diagnosis., JAMA Oncol, 2024. 10 (12)(12): p. 1689-1696., https://pubmed.ncbi.nlm.nih.gov/39480450/

73. Frazer, K, Bhardwaj, N, Fox, P, Stokes, D, Niranjan, V, Quinn, S, et.al. Systematic Review of Smoking Cessation Interventions for Smokers Diagnosed with Cancer., Int J Environ Res Public Health, 2022. 19 (24)(24):, https://pubmed.ncbi.nlm.nih.gov/36554894/

74. McRobbie, H, Bullen, C, Glover, M, Whittaker, R, Wallace-Bell, M, Fraser, T, New Zealand smoking cessation guidelines., N Z Med J, 2008. 121 (1276)(1276): p. 57-70., https://pubmed.ncbi.nlm.nih.gov/18574510/

75. Lindson, N, Theodoulou, A, Ordóñez-Mena, JM, Fanshawe, TR, Sutton, AJ, Livingstone-Banks, J, et.al. Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses., Cochrane Database Syst Rev, 2023. 9 (9)(9): p. CD015226., https://pubmed.ncbi.nlm.nih.gov/37696529/

76. Selbach, C, Siebel, C, Lilienthal, J, Grouven, U, Knelangen, M, Kastaun, S, et.al. Weaning From Tobacco with Nicotine or Varenicline in Severe and Mild Tobacco Dependence—Findings of a Meta-Analysis., Dtsch Arztebl Int, 2025. 122 (1)(1): p. 7-11., https://pubmed.ncbi.nlm.nih.gov/39628402/

77. Jose, T, Schroeder, DR, Warner, DO, Changes in Cigarette Smoking Behavior in Cancer Survivors During Diagnosis and Treatment., Nicotine Tob Res, 2022. 24 (10)(10): p. 1581-1588., https://pubmed.ncbi.nlm.nih.gov/35311999/

78. Streck, JM, Rigotti, NA, Livingstone-Banks, J, Tindle, HA, Clair, C, Munafò, MR, et.al. Interventions for smoking cessation in hospitalised patients., Cochrane Database Syst Rev, 2024. 5 (5)(5): p. CD001837., https://pubmed.ncbi.nlm.nih.gov/38770804/

79. Halms, T, Strasser, M, Hasan, A, Rüther, T, Trepel, M, Raab, S, et.al. Smoking and quality of life in lung cancer patients: systematic review., BMJ Support Palliat Care, 2024. 13 (e3)(e3): p. e686-e694., https://pubmed.ncbi.nlm.nih.gov/37607808/

80. Zeng, L, Yu, X, Yu, T, Xiao, J, Huang, Y, Interventions for smoking cessation in people diagnosed with lung cancer., Cochrane Database Syst Rev, 2019. 6 (6)(6): p. CD011751., https://pubmed.ncbi.nlm.nih.gov/31173336/

81. Pipe, AL, Evans, W, Papadakis, S, Smoking cessation: health system challenges and opportunities., Tob Control, 2022. 31 (2)(2): p. 340-347., https://pubmed.ncbi.nlm.nih.gov/35241609/

82. Glantz, SA, Nguyen, N, Oliveira da Silva, AL, Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes., NEJM Evid, 2024. 3 (3)(3): p. EVIDoa2300229., https://pubmed.ncbi.nlm.nih.gov/38411454/

83. Piñeiro, B, Simmons, VN, Palmer, AM, Correa, JB, Brandon, TH, Smoking cessation interventions within the context of Low-Dose Computed Tomography lung cancer screening: A systematic review., Lung Cancer, 2016. 98 (): p. 91-98., https://pubmed.ncbi.nlm.nih.gov/27393513/

84. Cadham, CJ, Jayasekera, JC, Advani, SM, Fallon, SJ, Stephens, JL, Braithwaite, D, et.al. Smoking cessation interventions for potential use in the lung cancer screening setting: A systematic review and meta-analysis., Lung Cancer, 2019. 135 (): p. 205-216., https://pubmed.ncbi.nlm.nih.gov/31446996/

85. Iaccarino, JM, Duran, C, Slatore, CG, Wiener, RS, Kathuria, H, Combining smoking cessation interventions with LDCT lung cancer screening: A systematic review., Prev Med, 2019. 121 (): p. 24-32., https://pubmed.ncbi.nlm.nih.gov/30753860/

86. Huang, S, Tang, O, Zheng, X, Li, H, Wu, Y, Yang, L, Effectiveness of smoking cessation on the high-risk population of lung cancer with early screening: a systematic review and meta-analysis of randomized controlled trials until January 2022., Arch Public Health, 2023. 81 (1)(1): p. 101., https://pubmed.ncbi.nlm.nih.gov/37268972/

87. Moldovanu, D, de Koning, HJ, van der Aalst, CM, Lung cancer screening and smoking cessation efforts., Transl Lung Cancer Res, 2021. 10 (2)(2): p. 1099-1109., https://pubmed.ncbi.nlm.nih.gov/33718048/

88. Steliga, MA, Yang, P, Integration of smoking cessation and lung cancer screening., Transl Lung Cancer Res, 2019. 8 (Suppl 1)(Suppl 1): p. S88-S94., https://pubmed.ncbi.nlm.nih.gov/31211109/

89. Taylor, KL, Hagerman, CJ, Luta, G, Bellini, PG, Stanton, C, Abrams, DB, et.al. Preliminary evaluation of a telephone-based smoking cessation intervention in the lung cancer screening setting: A randomized clinical trial., Lung Cancer, 2017. 108 (): p. 242-246., https://pubmed.ncbi.nlm.nih.gov/28216065/

90. Taylor, KL, Williams, RM, Li, T, Luta, G, Smith, L, Davis, KM, et.al. A Randomized Trial of Telephone-Based Smoking Cessation Treatment in the Lung Cancer Screening Setting., J Natl Cancer Inst, 2022. 114 (10)(10): p. 1410-1419., https://pubmed.ncbi.nlm.nih.gov/35818122/

91. Pastorino, U, Ladisa, V, Trussardo, S, Sabia, F, Rolli, L, Valsecchi, C, et.al. Cytisine Therapy Improved Smoking Cessation in the Randomized Screening and Multiple Intervention on Lung Epidemics Lung Cancer Screening Trial., J Thorac Oncol, 2022. 17 (11)(11): p. 1276-1286., https://pubmed.ncbi.nlm.nih.gov/35908731/

92. Lococo, F, Cardillo, G, Veronesi, G, Does a lung cancer screening programme promote smoking cessation?, Thorax, 2017. 72 (10)(10): p. 870-871., https://pubmed.ncbi.nlm.nih.gov/28747323/

93. Fucito, Lisa M, Czabafy, Sharon, Hendricks, Peter S, Kotsen, Chris, Richardson, Donna, Toll, Benjamin A, et.al. Pairing smoking-cessation services with lung cancer screening: A clinical guideline from the Association for the Treatment of Tobacco Use and Dependence and the Society for Research on Nicotine and Tobacco., Cancer, 2016., https://www.ncbi.nlm.nih.gov/pubmed/26916412

94. Minnix, JA, Karam-Hage, M, Blalock, JA, Cinciripini, PM, The importance of incorporating smoking cessation into lung cancer screening., Transl Lung Cancer Res, 2018. 7 (3)(3): p. 272-280., https://pubmed.ncbi.nlm.nih.gov/30050765/

95. Joseph, AM, Rothman, AJ, Almirall, D, Begnaud, A, Chiles, C, Cinciripini, PM, et.al. Lung Cancer Screening and Smoking Cessation Clinical Trials. SCALE (Smoking Cessation within the Context of Lung Cancer Screening) Collaboration., Am J Respir Crit Care Med, 2018. 197 (2)(2): p. 172-182., https://pubmed.ncbi.nlm.nih.gov/28977754/

96. Heiden, BT, Eaton, DB, Chang, SH, Yan, Y, Schoen, MW, Chen, LS, et.al. Assessment of Duration of Smoking Cessation Prior to Surgical Treatment of Non-small Cell Lung Cancer., Ann Surg, 2023. 277 (4)(4): p. e933-e940., https://pubmed.ncbi.nlm.nih.gov/34793352/

97. Mills, E, Eyawo, O, Lockhart, I, Kelly, S, Wu, P, Ebbert, JO, Smoking cessation reduces postoperative complications: a systematic review and meta-analysis., Am J Med, 2011. 124 (2)(2): p. 144-154.e8., https://pubmed.ncbi.nlm.nih.gov/21295194/

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857. Daly, ME, Singh, N, Ismaila, N, Management of Stage III Non-Small Cell Lung Cancer: ASCO Guideline Rapid Recommendation Update., J Clin Oncol, 2024. 42 (25)(25): p. 3058-3060., https://pubmed.ncbi.nlm.nih.gov/39042842/

858. Aigner, C, Baldes, N, Begic, M, Doerr, F, Hoda, MA, Bölükbas, S, Current perspective on resectability in stage III locally advanced NSCLC - The thoracic surgeons' view., Eur J Cancer, 2025. 221 (): p. 115426., https://pubmed.ncbi.nlm.nih.gov/40239401/

859. Lorenzi, W, Mercier, O, The role of extracorporeal life support in extended lung resections for non-small cell lung cancer: a narrative review., J Thorac Dis, 2023. 15 (9)(9): p. 5232-5238., https://pubmed.ncbi.nlm.nih.gov/37868859/

860. D'Andrilli, A, Trabalza Marinucci, B, Ciccone, AM, Ibrahim, M, Andreetti, C, Messa, F, et.al. Carinal Reconstruction for Lung Cancer and Airway Tumors: Long-term Results., Ann Thorac Surg, 2025. 120 (2)(2): p. 271-281., https://pubmed.ncbi.nlm.nih.gov/39447856/

861. Provencio, M, Nadal, E, Insa, A, García-Campelo, MR, Casal-Rubio, J, Dómine, M, et.al. Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial., Lancet Oncol, 2020. 21 (11)(11): p. 1413-1422., https://pubmed.ncbi.nlm.nih.gov/32979984/

862. Provencio, Mariano, Awad, Mark M., Spicer, Jonathan, Janssens, Annelies, Moiseenko, Fedor Vladimirovich, Gao, Yang, et.al. Clinical outcomes with perioperative nivolumab (NIVO) by nodal status among patients (pts) with stage III resectable NSCLC: Results from the phase 3 CheckMate 77T study.Wolters Kluwer, Journal of Clinical Oncology, 2024. 42(17_suppl): p. LBA8007 - LBA8007., https://doi.org/10.1200/JCO.2024.42.17_suppl.LBA8007

863. Albain, K. S., Swann, R. S., Rusch, V. W., Turrisi, A. T., 3rd, Shepherd, F. A., Smith, C., et.al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial, Lancet, 2009. 374(9687): p. 379-86., https://www.ncbi.nlm.nih.gov/pubmed/19632716

864. Rusch, VW, Crowley, J, Giroux, DJ, Goldstraw, P, Im, JG, Tsuboi, M, et.al. The IASLC Lung Cancer Staging Project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer., J Thorac Oncol, 2007. 2 (7)(7): p. 603-12., https://pubmed.ncbi.nlm.nih.gov/17607115/

865. Silvestri, G. A., Gonzalez, A. V., Jantz, M. A., Margolis, M. L., Gould, M. K., Tanoue, L. T., et.al. Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 2013. 143(5 Suppl): p. e211S-50S., https://www.ncbi.nlm.nih.gov/pubmed/23649440

866. Dehing-Oberije, C, De Ruysscher, D, van der Weide, H, Hochstenbag, M, Bootsma, G, Geraedts, W, et.al. Tumor volume combined with number of positive lymph node stations is a more important prognostic factor than TNM stage for survival of non-small-cell lung cancer patients treated with (chemo)radiotherapy., Int J Radiat Oncol Biol Phys, 2008. 70 (4)(4): p. 1039-44., https://pubmed.ncbi.nlm.nih.gov/17889446/

867. Hishida, T, Yoshida, J, Nishimura, M, Nishiwaki, Y, Nagai, K, Problems in the current diagnostic standards of clinical N1 non-small cell lung cancer., Thorax, 2008. 63 (6)(6): p. 526-31., https://pubmed.ncbi.nlm.nih.gov/18024539/

868. Wang, J, Welch, K, Wang, L, Kong, FM, Negative predictive value of positron emission tomography and computed tomography for stage T1-2N0 non-small-cell lung cancer: a meta-analysis., Clin Lung Cancer, 2012. 13 (2)(2): p. 81-9., https://pubmed.ncbi.nlm.nih.gov/22056226/

869. Gómez-Caro, A, Boada, M, Cabañas, M, Sanchez, M, Arguis, P, Lomeña, F, et.al. False-negative rate after positron emission tomography/computer tomography scan for mediastinal staging in cI stage non-small-cell lung cancer., Eur J Cardiothorac Surg, 2012. 42 (1)(1): p. 93-100; discussion 100., https://pubmed.ncbi.nlm.nih.gov/22290911/

870. Pieterman, RM, van Putten, JW, Meuzelaar, JJ, Mooyaart, EL, Vaalburg, W, Koëter, GH, et.al. Preoperative staging of non-small-cell lung cancer with positron-emission tomography., N Engl J Med, 2000. 343 (4)(4): p. 254-61., https://pubmed.ncbi.nlm.nih.gov/10911007/

871. De Leyn, P, Stroobants, S, De Wever, W, Lerut, T, Coosemans, W, Decker, G, et.al. Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage IIIA-N2 Non-small-cell lung cancer: a Leuven Lung Cancer Group Study., J Clin Oncol, 2006. 24 (21)(21): p. 3333-9., https://pubmed.ncbi.nlm.nih.gov/16849747/

872. Fischer, B, Lassen, U, Mortensen, J, Larsen, S, Loft, A, Bertelsen, A, et.al. Preoperative staging of lung cancer with combined PET-CT., N Engl J Med, 2009. 361 (1)(1): p. 32-9., https://pubmed.ncbi.nlm.nih.gov/19571281/

873. Fischer, BM, Mortensen, J, Hansen, H, Vilmann, P, Larsen, SS, Loft, A, et.al. Multimodality approach to mediastinal staging in non-small cell lung cancer. Faults and benefits of PET-CT: a randomised trial., Thorax, 2011. 66 (4)(4): p. 294-300., https://pubmed.ncbi.nlm.nih.gov/21169287/

874. Annema, Jouke T., van Meerbeeck, Jan P., Rintoul, Robert C., Dooms, Christophe, Deschepper, Ellen, Dekkers, Olaf M., et.al. Mediastinoscopy vs Endosonography for Mediastinal Nodal Staging of Lung Cancer: A Randomized Trial, JAMA, 2010. 304(20): p. 2245 - 2252., https://doi.org/10.1001/jama.2010.1705

875. Yasufuku, K, Pierre, A, Darling, G, de Perrot, M, Waddell, T, Johnston, M, et.al. A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer., J Thorac Cardiovasc Surg, 2011. 142 (6)(6): p. 1393-400.e1., https://pubmed.ncbi.nlm.nih.gov/21963329/

876. Herth, FJ, Eberhardt, R, Krasnik, M, Ernst, A, Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically and positron emission tomography-normal mediastinum in patients with lung cancer., Chest, 2008. 133 (4)(4): p. 887-91., https://pubmed.ncbi.nlm.nih.gov/18263680/

877. Bousema, JE, van Dorp, M, Noyez, VJJM, Dijkgraaf, MGW, Annema, JT, van den Broek, FJC, Unforeseen N2 Disease after Negative Endosonography Findings with or without Confirmatory Mediastinoscopy in Resectable Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis., J Thorac Oncol, 2019. 14 (6)(6): p. 979-992., https://pubmed.ncbi.nlm.nih.gov/30905829/

878. Tokito, T, Azuma, K, Kawahara, A, Ishii, H, Yamada, K, Matsuo, N, et.al. Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy., Eur J Cancer, 2016. 55 (): p. 7-14., https://pubmed.ncbi.nlm.nih.gov/26771872/

879. Lin, Steven H., Lin, Yan, Price, Justina, Parker, Matthew, Gomez, Daniel Richard, Welsh, James William, et.al. DETERRED: PD-L1 blockade to evaluate the safety of lung cancer therapy using carboplatin, paclitaxel, and radiation combined with MPDL3280A (atezolizumab).Wolters Kluwer, Journal of Clinical Oncology, 2017. 35(15_suppl): p. 3064 - 3064., https://doi.org/10.1200/JCO.2017.35.15_suppl.3064

880. Durm, Greg Andrew, Althouse, Sandra K., Sadiq, Ahad Ali, Jalal, Shadia Ibrahim, Jabbour, Salma, Zon, Robin, et.al. Phase II trial of concurrent chemoradiation with consolidation pembrolizumab in patients with unresectable stage III non-small cell lung cancer: Hoosier Cancer Research Network LUN 14-179.Wolters Kluwer, Journal of Clinical Oncology, 2018. 36(15_suppl): p. 8500 - 8500., https://doi.org/10.1200/JCO.2018.36.15_suppl.8500

881. Peters, S, Felip, E, Dafni, U, Belka, C, Guckenberger, M, Irigoyen, A, et.al. Safety evaluation of nivolumab added concurrently to radiotherapy in a standard first line chemo-radiotherapy regimen in stage III non-small cell lung cancer-The ETOP NICOLAS trial., Lung Cancer, 2019. 133 (): p. 83-87., https://pubmed.ncbi.nlm.nih.gov/31200833/

882. Faivre-Finn, C, Vicente, D, Kurata, T, Planchard, D, Paz-Ares, L, Vansteenkiste, JF, et.al. Four-Year Survival With Durvalumab After Chemoradiotherapy in Stage III NSCLC-an Update From the PACIFIC Trial., J Thorac Oncol, 2021. 16 (5)(5): p. 860-867., https://pubmed.ncbi.nlm.nih.gov/33476803/

883. Antonia, SJ, Villegas, A, Daniel, D, Vicente, D, Murakami, S, Hui, R, et.al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC., N Engl J Med, 2018. 379 (24)(24): p. 2342-2350., https://pubmed.ncbi.nlm.nih.gov/30280658/

884. Hui, R, Özgüroğlu, M, Villegas, A, Daniel, D, Vicente, D, Murakami, S, et.al. Patient-reported outcomes with durvalumab after chemoradiotherapy in stage III, unresectable non-small-cell lung cancer (PACIFIC): a randomised, controlled, phase 3 study., Lancet Oncol, 2019. 20 (12)(12): p. 1670-1680., https://pubmed.ncbi.nlm.nih.gov/31601496/

885. Paz-Ares, L, Spira, A, Raben, D, Planchard, D, Cho, BC, Özgüroğlu, M, et.al. Outcomes with durvalumab by tumour PD-L1 expression in unresectable, stage III non-small-cell lung cancer in the PACIFIC trial., Ann Oncol, 2020. 31 (6)(6): p. 798-806., https://pubmed.ncbi.nlm.nih.gov/32209338/

886. Ghysen, K, Vansteenkiste, J, Immunotherapy in patients with early stage resectable nonsmall cell lung cancer., Curr Opin Oncol, 2019. 31 (1)(1): p. 13-17., https://pubmed.ncbi.nlm.nih.gov/30325753/

887. Vansteenkiste, J, Wauters, E, Reymen, B, Ackermann, CJ, Peters, S, De Ruysscher, D, Current status of immune checkpoint inhibition in early-stage NSCLC., Ann Oncol, 2019. 30 (8)(8): p. 1244-1253., https://pubmed.ncbi.nlm.nih.gov/31143921/

888. Forde, PM, Chaft, JE, Smith, KN, Anagnostou, V, Cottrell, TR, Hellmann, MD, et.al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer., N Engl J Med, 2018. 378 (21)(21): p. 1976-1986., https://pubmed.ncbi.nlm.nih.gov/29658848/

889. Hill, A, Gong, J, Wilczynski, S, Mirza, R, Erhunmwunsee, L, Salgia, R, Complete Pathologic Response When Adding Pembrolizumab to Neoadjuvant Chemotherapy in Stage IIIA Non-Small-Cell Lung Cancer., J Oncol Pract, 2018. 14 (9)(9): p. 569-571., https://pubmed.ncbi.nlm.nih.gov/30044685/

890. Shu, CA, Gainor, JF, Awad, MM, Chiuzan, C, Grigg, CM, Pabani, A, et.al. Neoadjuvant atezolizumab and chemotherapy in patients with resectable non-small-cell lung cancer: an open-label, multicentre, single-arm, phase 2 trial., Lancet Oncol, 2020. 21 (6)(6): p. 786-795., https://pubmed.ncbi.nlm.nih.gov/32386568/

891. Kwiatkowski, David J., Rusch, Valerie W., Chaft, Jamie E., Johnson, Bruce E., Nicholas, Alan, Wistuba, Ignacio Ivan, et.al. Neoadjuvant atezolizumab in resectable non-small cell lung cancer (NSCLC): Interim analysis and biomarker data from a multicenter study (LCMC3), Journal of Clinical Oncology, 2019. 37(15_suppl): p. 8503-8503., https://doi.org/10.1200/JCO.2019.37.15_suppl.8503

892. Felip, E, Altorki, N, Zhou, C, Csőszi, T, Vynnychenko, I, Goloborodko, O, et.al. Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial., Lancet, 2021. 398 (10308)(10308): p. 1344-1357., https://pubmed.ncbi.nlm.nih.gov/34555333/

893. Goss, GD, O'Callaghan, C, Lorimer, I, Tsao, MS, Masters, GA, Jett, J, et.al. Gefitinib versus placebo in completely resected non-small-cell lung cancer: results of the NCIC CTG BR19 study., J Clin Oncol, 2013. 31 (27)(27): p. 3320-6., https://pubmed.ncbi.nlm.nih.gov/23980091/

894. Tsuboi, M, Kato, H, Nagai, K, Tsuchiya, R, Wada, H, Tada, H, et.al. Gefitinib in the adjuvant setting: safety results from a phase III study in patients with completely resected non-small cell lung cancer., Anticancer Drugs, 2005. 16 (10)(10): p. 1123-8., https://pubmed.ncbi.nlm.nih.gov/16222155/

895. Pennell, NA, Neal, JW, Chaft, JE, Azzoli, CG, Jänne, PA, Govindan, R, et.al. SELECT: A Phase II Trial of Adjuvant Erlotinib in Patients With Resected Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer., J Clin Oncol, 2019. 37 (2)(2): p. 97-104., https://pubmed.ncbi.nlm.nih.gov/30444685/

896. D'Angelo, SP, Janjigian, YY, Ahye, N, Riely, GJ, Chaft, JE, Sima, CS, et.al. Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib., J Thorac Oncol, 2012. 7 (12)(12): p. 1815-1822., https://pubmed.ncbi.nlm.nih.gov/23154553/

897. Janjigian, YY, Park, BJ, Zakowski, MF, Ladanyi, M, Pao, W, D'Angelo, SP, et.al. Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations., J Thorac Oncol, 2011. 6 (3)(3): p. 569-75., https://pubmed.ncbi.nlm.nih.gov/21150674/

898. Kelly, K, Altorki, NK, Eberhardt, WE, O'Brien, ME, Spigel, DR, Crinò, L, et.al. Adjuvant Erlotinib Versus Placebo in Patients With Stage IB-IIIA Non-Small-Cell Lung Cancer (RADIANT): A Randomized, Double-Blind, Phase III Trial., J Clin Oncol, 2015. 33 (34)(34): p. 4007-14., https://pubmed.ncbi.nlm.nih.gov/26324372/

899. Zhong, WZ, Wang, Q, Mao, WM, Xu, ST, Wu, L, Shen, Y, et.al. Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase 3 study., Lancet Oncol, 2018. 19 (1)(1): p. 139-148., https://pubmed.ncbi.nlm.nih.gov/29174310/

900. Wu, Y. L., Tsuboi, M., He, J., John, T., Grohe, C., Majem, M., et.al. Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer, N Engl J Med, 2020. 383(18): p. 1711-1723., https://www.nejm.org/doi/full/10.1056/NEJMoa2027071

901. Jelinek, MJ, Aggarwal, C, Adjuvant Osimertinib: A New Standard of Care., Oncologist, 2021. 26 (4)(4): p. 263-265., https://pubmed.ncbi.nlm.nih.gov/33301209/

902. Riquet, M, Mordant, P, Pricopi, C, Legras, A, Foucault, C, Dujon, A, et.al. A review of 250 ten-year survivors after pneumonectomy for non-small-cell lung cancer., Eur J Cardiothorac Surg, 2014. 45 (5)(5): p. 876-81., https://pubmed.ncbi.nlm.nih.gov/24132299/

903. Skrzypczak, P, Kasprzyk, M, Kamiński, M, Gabryel, P, Ochman, M, Chwalba, A, et.al. Key risk factors for mortality after pneumonectomy for lung cancer: insights from a large single-center cohort study., J Thorac Dis, 2025. 17 (7)(7): p. 4536-4549., https://pubmed.ncbi.nlm.nih.gov/40809274/

904. Deslauriers, J, Grégoire, J, Jacques, LF, Piraux, M, Guojin, L, Lacasse, Y, Sleeve lobectomy versus pneumonectomy for lung cancer: a comparative analysis of survival and sites or recurrences., Ann Thorac Surg, 2004. 77 (4)(4): p. 1152-6; discussion 1156., https://pubmed.ncbi.nlm.nih.gov/15063224/

905. Beauchamp, G, Fundamentals of Standard Sleeve Resection., Thorac Surg Clin, 2018. 28 (3)(3): p. 285-289., https://pubmed.ncbi.nlm.nih.gov/30054065/

906. Chen, J, Soultanis, KM, Sun, F, Gonzalez-Rivas, D, Duan, L, Wu, L, et.al. Outcomes of sleeve lobectomy versus pneumonectomy: A propensity score-matched study., J Thorac Cardiovasc Surg, 2021. 162 (6)(6): p. 1619-1628.e4., https://pubmed.ncbi.nlm.nih.gov/32919775/

907. Ma, Z, Dong, A, Fan, J, Cheng, H, Does sleeve lobectomy concomitant with or without pulmonary artery reconstruction (double sleeve) have favorable results for non-small cell lung cancer compared with pneumonectomy? A meta-analysis., Eur J Cardiothorac Surg, 2007. 32 (1)(1): p. 20-8., https://pubmed.ncbi.nlm.nih.gov/17442581/

908. Voltolini, L, Gonfiotti, A, Viggiano, D, Borgianni, S, Farronato, A, Bongiolatti, S, Extended sleeve-lobectomy for centrally located locally advanced non-small cell lung cancer is a feasible approach to avoid pneumonectomy., J Thorac Dis, 2020. 12 (8)(8): p. 4090-4098., https://pubmed.ncbi.nlm.nih.gov/32944320/

909. Shen, H, Wang, X, Nie, Y, Zhang, K, Wei, Z, Yang, F, et.al. Minimally invasive surgery versus thoracotomy for resectable stage II and III non-small-cell lung cancers: a systematic review and meta-analysis., Eur J Cardiothorac Surg, 2021. 59 (5)(5): p. 940-950., https://pubmed.ncbi.nlm.nih.gov/33370437/

910. Li, X, Huang, K, Deng, H, Zheng, Q, Xiao, T, Yu, J, et.al. Feasibility and oncological outcomes of video-assisted thoracic surgery versus thoracotomy for pathologic N2 disease in non-small cell lung cancer: A comprehensive systematic review and meta-analysis., Thorac Cancer, 2022. 13 (21)(21): p. 2917-2928., https://pubmed.ncbi.nlm.nih.gov/36102196/

911. Liu, S, Li, S, Tang, Y, Chen, R, Qiao, G, Minimally invasive surgery vs. open thoracotomy for non-small-cell lung cancer with N2 disease: a systematic review and meta-analysis., Front Med (Lausanne), 2023. 10 (): p. 1152421., https://pubmed.ncbi.nlm.nih.gov/37324136/

912. Li, Y, Mei, J, Yang, Z, Guo, C, Liu, C, Liao, H, et.al. Ten-year survival outcomes of video-assisted thoracic surgery , Transl Lung Cancer Res, 2024. 13 (9)(9): p. 2162-2174., https://pubmed.ncbi.nlm.nih.gov/39430323/

913. Chen, T, Chan, EG, Huang, B, Bertolaccini, L, Fernando, HC, Tasoudis, PT, et.al. Outcomes following minimally invasive approaches , Transl Lung Cancer Res, 2024. 13 (2)(2): p. 334-344., https://pubmed.ncbi.nlm.nih.gov/38496690/

914. Pan, H, Chen, H, Kong, W, Ning, J, Ge, Z, Tian, Y, et.al. Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Following Neoadjuvant Immunochemotherapy in Resectable Stage III Non-Small Cell Lung Cancer Among Chinese Populations: A Multi-Center Retrospective Cohort Study., Clin Lung Cancer, 2024. 25 (5)(5): p. 395-406.e5., https://pubmed.ncbi.nlm.nih.gov/38705833/

915. Liu, S, Li, S, Tang, Y, Chen, R, Qiao, G, Minimally invasive surgery vs. open thoracotomy for non-small-cell lung cancer with N2 disease: a systematic review and meta-analysis., Front Med (Lausanne), 2023. 10 (): p. 1152421., https://pubmed.ncbi.nlm.nih.gov/37324136/

916. Tsubokawa, N, Tsutani, Y, Hishida, T, Saji, H, Wakabayashi, M, Endo, M, et.al. Quality comparison of mediastinal lymph node dissection between video-assisted thoracic surgery and open thoracotomy: a supplementary analysis of the phase 3 Japan Clinical Oncology Group 1413 trial†., Eur J Cardiothorac Surg, 2025. 67 (7)(7):, https://pubmed.ncbi.nlm.nih.gov/40578313/

917. Xu, Z, Li, C, Ni, Y, Gu, B, Zhou, H, Luo, Y, et.al. Retrospective comparative study of thoracoscopic lobectomy vs. segmentectomy: Enhancing recovery and lung function in early-stage non-small cell lung cancer., Medicine (Baltimore), 2025. 104 (47)(47): p. e45655., https://pubmed.ncbi.nlm.nih.gov/41305814/

918. Wang, C, Wu, S, Zhang, R, Jin, K, Qian, Y, Mao, N, et.al. Identifying Lung Cancer Patients Suitable for Segmentectomy: A Brief Review., Front Surg, 2021. 8 (): p. 637441., https://pubmed.ncbi.nlm.nih.gov/34307441/

919. Suzuki, S, Asakura, K, Masai, K, Kaseda, K, Hishida, T, Kazama, A, et.al. Real-World Outcomes of Limited Resection for Tumours Greater Than 20 mm in Non-Small Cell Lung Cancer., Eur J Cardiothorac Surg, 2025. 67 (10)(10):, https://pubmed.ncbi.nlm.nih.gov/41017644/

920. Kent, M, Landreneau, R, Mandrekar, S, Hillman, S, Nichols, F, Jones, D, et.al. Segmentectomy versus wedge resection for non-small cell lung cancer in high-risk operable patients., Ann Thorac Surg, 2013. 96 (5)(5): p. 1747-54; discussion 1754-5., https://pubmed.ncbi.nlm.nih.gov/23998400/

921. Lardinois, D, De Leyn, P, Van Schil, P, Porta, RR, Waller, D, Passlick, B, et.al. ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer., Eur J Cardiothorac Surg, 2006. 30 (5)(5): p. 787-92., https://pubmed.ncbi.nlm.nih.gov/16971134/

922. Mokhles, S, Macbeth, F, Treasure, T, Younes, RN, Rintoul, RC, Fiorentino, F, et.al. Systematic lymphadenectomy versus sampling of ipsilateral mediastinal lymph-nodes during lobectomy for non-small-cell lung cancer: a systematic review of randomized trials and a meta-analysis., Eur J Cardiothorac Surg, 2017. 51 (6)(6): p. 1149-1156., https://pubmed.ncbi.nlm.nih.gov/28158453/

923. Liu, Z, Liu, Y, Xie, C, Yang, J, Zeng, B, Yeung, SJ, et.al. Vagus nerve and phrenic nerve guided systematic nodal dissection for lung cancer., J Thorac Dis, 2019. 11 (9)(9): p. 4021-4027., https://pubmed.ncbi.nlm.nih.gov/31656677/

924. Liu, Y, Yang, W, Yang, J, Liao, S, Liu, Z, Zeng, B, et.al. Impact on quality of life after vagus nerve and phrenic nerve guided systematic nodal dissection for non-small cell lung cancer patients: a prospective, single-arm clinical trial., Ann Transl Med, 2021. 9 (24)(24): p. 1753., https://pubmed.ncbi.nlm.nih.gov/35071447/

925. Stoelben, E, Ludwig, C, Chest wall resection for lung cancer: indications and techniques., Eur J Cardiothorac Surg, 2009. 35 (3)(3): p. 450-6., https://pubmed.ncbi.nlm.nih.gov/19188079/

926. Elia, S, Griffo, S, Gentile, M, Costabile, R, Ferrante, G, Surgical treatment of lung cancer invading chest wall: a retrospective analysis of 110 patients., Eur J Cardiothorac Surg, 2001. 20 (2)(2): p. 356-60., https://pubmed.ncbi.nlm.nih.gov/11463557/

927. Santos, HT, Lopes, AJ, Higa, C, Nunes, RA, Saito, EH, Lung cancer with chest wall invasion: retrospective analysis comparing en-bloc resection and 'resection in bird cage'., J Cardiothorac Surg, 2014. 9 (): p. 57., https://pubmed.ncbi.nlm.nih.gov/24655354/

928. Yuan, M, Men, Y, Kang, J, Sun, X, Zhao, M, Bao, Y, et.al. Postoperative radiotherapy for pathological stage IIIA-N2 non-small cell lung cancer with positive surgical margins., Thorac Cancer, 2021. 12 (2)(2): p. 227-234., https://pubmed.ncbi.nlm.nih.gov/33247556/

929. Edwards, JG, Chansky, K, Van Schil, P, Nicholson, AG, Boubia, S, Brambilla, E, et.al. The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non-Small Cell Lung Cancer., J Thorac Oncol, 2020. 15 (3)(3): p. 344-359., https://pubmed.ncbi.nlm.nih.gov/31731014/

930. Gu, C, Wang, R, Pan, X, Huang, Q, Luo, J, Zheng, J, et.al. Comprehensive study of prognostic risk factors of patients underwent pneumonectomy., J Cancer, 2017. 8 (11)(11): p. 2097-2103., https://pubmed.ncbi.nlm.nih.gov/28819411/

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965. Garon, EB, Hellmann, MD, Rizvi, NA, Carcereny, E, Leighl, NB, Ahn, MJ, et.al. Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study., J Clin Oncol, 2019. 37 (28)(28): p. 2518-2527., https://pubmed.ncbi.nlm.nih.gov/31154919/

966. Borghaei, H, Gettinger, S, Vokes, EE, Chow, LQM, Burgio, MA, de Castro Carpeno, J, et.al. Five-Year Outcomes From the Randomized, Phase III Trials CheckMate 017 and 057: Nivolumab Versus Docetaxel in Previously Treated Non-Small-Cell Lung Cancer., J Clin Oncol, 2021. 39 (7)(7): p. 723-733., https://pubmed.ncbi.nlm.nih.gov/33449799/

967. Gandhi, L, Rodríguez-Abreu, D, Gadgeel, S, Esteban, E, Felip, E, De Angelis, F, et.al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer., N Engl J Med, 2018. 378 (22)(22): p. 2078-2092., https://pubmed.ncbi.nlm.nih.gov/29658856/

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972. Paz-Ares, L, Luft, A, Vicente, D, Tafreshi, A, Gümüş, M, Mazières, J, et.al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer., N Engl J Med, 2018. 379 (21)(21): p. 2040-2051., https://pubmed.ncbi.nlm.nih.gov/30280635/

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1009. Chiappetta, M, Leuzzi, G, Sperduti, I, Bria, E, Mucilli, F, Lococo, F, et.al. Mediastinal Up-Staging During Surgery in Non-Small-Cell Lung Cancer: Which Mediastinal Lymph Node Metastasis Patterns Better Predict The Outcome? A Multicenter Analysis., Clin Lung Cancer, 2020. 21 (5)(5): p. 464-471.e1., https://pubmed.ncbi.nlm.nih.gov/32389508/

1010. Billiet, C, De Ruysscher, D, Peeters, S, Decaluwé, H, Vansteenkiste, J, Dooms, C, et.al. Patterns of Locoregional Relapses in Patients with Contemporarily Staged Stage III-N2 NSCLC Treated with Induction Chemotherapy and Resection: Implications for Postoperative Radiotherapy Target Volumes., J Thorac Oncol, 2016. 11 (9)(9): p. 1538-49., https://pubmed.ncbi.nlm.nih.gov/27374454/

1011. Chun, SG, Hu, C, Choy, H, Komaki, RU, Timmerman, RD, Schild, SE, et.al. Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial., J Clin Oncol, 2017. 35 (1)(1): p. 56-62., https://pubmed.ncbi.nlm.nih.gov/28034064/

1012. Arriagada, R, Dunant, A, Pignon, JP, Bergman, B, Chabowski, M, Grunenwald, D, et.al. Long-term results of the international adjuvant lung cancer trial evaluating adjuvant Cisplatin-based chemotherapy in resected lung cancer., J Clin Oncol, 2010. 28 (1)(1): p. 35-42., https://pubmed.ncbi.nlm.nih.gov/19933916/

1013. Sun, X, Men, Y, Wang, J, Bao, Y, Yang, X, Zhao, M, et.al. Risk of cardiac-related mortality in stage IIIA-N2 non-small cell lung cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) database., Thorac Cancer, 2021. 12 (9)(9): p. 1358-1365., https://pubmed.ncbi.nlm.nih.gov/33728811/

1014. Rieber, J, Deeg, A, Ullrich, E, Foerster, R, Bischof, M, Warth, A, et.al. Outcome and prognostic factors of postoperative radiation therapy (PORT) after incomplete resection of non-small cell lung cancer (NSCLC)., Lung Cancer, 2016. 91 (): p. 41-7., https://pubmed.ncbi.nlm.nih.gov/26711933/

1015. Dillman, R. O., Herndon, J., Seagren, S. L., Eaton, W. L., Jr., Green, M. R., Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial, J Natl Cancer Inst, 1996. 88(17): p. 1210-5., https://www.ncbi.nlm.nih.gov/pubmed/8780630

1016. Le, Chevalier T., Arriagada, R., Quoix, E., Ruffie, P., Martin, M., Douillard, J. Y., et.al. Radiotherapy alone versus combined chemotherapy and radiotherapy in unresectable non-small cell lung carcinoma, Lung Cancer, 1994. 10 Suppl 1: p. S239-S244., https://www.ncbi.nlm.nih.gov/pubmed/8087515

1017. Behera, M, Steuer, CE, Liu, Y, Fernandez, F, Fu, C, Higgins, KA, et.al. Trimodality Therapy in the Treatment of Stage III N2-Positive Non-Small Cell Lung Cancer: A National Cancer Database Analysis., Oncologist, 2020. 25 (6)(6): p. e964-e975., https://pubmed.ncbi.nlm.nih.gov/31943520/

1018. Farray, D, Mirkovic, N, Albain, KS, Multimodality therapy for stage III non-small-cell lung cancer., J Clin Oncol, 2005. 23 (14)(14): p. 3257-69., https://pubmed.ncbi.nlm.nih.gov/15886313/

1019. Decaluwé, H, De Leyn, P, Vansteenkiste, J, Dooms, C, Van Raemdonck, D, Nafteux, P, et.al. Surgical multimodality treatment for baseline resectable stage IIIA-N2 non-small cell lung cancer. Degree of mediastinal lymph node involvement and impact on survival., Eur J Cardiothorac Surg, 2009. 36 (3)(3): p. 433-9., https://pubmed.ncbi.nlm.nih.gov/19502079/

1020. Sause, W., Kolesar, P., Taylor, S. Iv, Johnson, D., Livingston, R., Komaki, R., et.al. Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Chest, 2000. 117(2): p. 358-364., https://www.ncbi.nlm.nih.gov/pubmed/10669675

1021. Senan, S, Brade, A, Wang, LH, Vansteenkiste, J, Dakhil, S, Biesma, B, et.al. PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer., J Clin Oncol, 2016. 34 (9)(9): p. 953-62., https://pubmed.ncbi.nlm.nih.gov/26811519/

1022. van Meerbeeck, J. P., Kramer, G. W., Van Schil, P. E., Legrand, C., Smit, E. F., Schramel, F., et.al. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer, J Natl Cancer Inst, 2007. 99(6): p. 442-50., https://www.ncbi.nlm.nih.gov/pubmed/17374834

1023. Van Schil, P, Van Meerbeeck, J, Kramer, G, Splinter, T, Legrand, C, Giaccone, G, et.al. Morbidity and mortality in the surgery arm of EORTC 08941 trial., Eur Respir J, 2005. 26 (2)(2): p. 192-7., https://pubmed.ncbi.nlm.nih.gov/16055865/

1024. Junker, K, Langner, K, Klinke, F, Bosse, U, Thomas, M, Grading of tumor regression in non-small cell lung cancer : morphology and prognosis., Chest, 2001. 120 (5)(5): p. 1584-91., https://pubmed.ncbi.nlm.nih.gov/11713138/

1025. Eberhardt, WE, Stamatis, G, Stuschke, M, Surgery in stage III non-small-cell lung cancer., Lancet, 2009. 374 (9687)(9687): p. 359-60., https://pubmed.ncbi.nlm.nih.gov/19632715/

1026. Pöttgen, C, Eberhardt, W, Bildat, S, Stüben, G, Stamatis, G, Hillejan, L, et.al. Induction chemotherapy followed by concurrent chemotherapy and definitive high-dose radiotherapy for patients with locally advanced non-small-cell lung cancer (stages IIIa/IIIb): a pilot phase I/II trial., Ann Oncol, 2002. 13 (3)(3): p. 403-11., https://pubmed.ncbi.nlm.nih.gov/11996471/

1027. Vansteenkiste, J, De Ruysscher, D, Eberhardt, WE, Lim, E, Senan, S, Felip, E, et.al. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up., Ann Oncol, 2013. 24 Suppl 6 (): p. vi89-98., https://pubmed.ncbi.nlm.nih.gov/23860613/

1028. Friedel, G, Budach, W, Dippon, J, Spengler, W, Eschmann, SM, Pfannenberg, C, et.al. Phase II trial of a trimodality regimen for stage III non-small-cell lung cancer using chemotherapy as induction treatment with concurrent hyperfractionated chemoradiation with carboplatin and paclitaxel followed by subsequent resection: a single-center study., J Clin Oncol, 2010. 28 (6)(6): p. 942-8., https://pubmed.ncbi.nlm.nih.gov/20100967/

1029. Pezzetta, E, Stupp, R, Zouhair, A, Guillou, L, Taffé, P, von Briel, C, et.al. Comparison of neoadjuvant cisplatin-based chemotherapy versus radiochemotherapy followed by resection for stage III (N2) NSCLC., Eur J Cardiothorac Surg, 2005. 27 (6)(6): p. 1092-8., https://pubmed.ncbi.nlm.nih.gov/15896624/

1030. Früh, M, Betticher, DC, Stupp, R, Xyrafas, A, Peters, S, Ris, HB, et.al. Multimodal Treatment in Operable Stage III NSCLC: A Pooled Analysis on Long-Term Results of Three SAKK trials (SAKK 16/96, 16/00, and 16/01)., J Thorac Oncol, 2019. 14 (1)(1): p. 115-123., https://pubmed.ncbi.nlm.nih.gov/30267838/

1031. Pöttgen, C, Gauler, T, Bellendorf, A, Guberina, M, Bockisch, A, Schwenzer, N, et.al. Standardized Uptake Decrease on [18F]-Fluorodeoxyglucose Positron Emission Tomography After Neoadjuvant Chemotherapy Is a Prognostic Classifier for Long-Term Outcome After Multimodality Treatment: Secondary Analysis of a Randomized Trial for Resectable Stage IIIA/B Non-Small-Cell Lung Cancer., J Clin Oncol, 2016. 34 (21)(21): p. 2526-33., https://pubmed.ncbi.nlm.nih.gov/27247220/

1032. Pöttgen, C, Eberhardt, W, Stamatis, G, Stuschke, M, Definitive radiochemotherapy versus surgery within multimodality treatment in stage III non-small cell lung cancer (NSCLC) - a cumulative meta-analysis of the randomized evidence., Oncotarget, 2017. 8 (25)(25): p. 41670-41678., https://pubmed.ncbi.nlm.nih.gov/28415831/

1033. Friedel, G., Hruska, D., Budach, W., Wolf, M., Kyriss, T., Hurtgen, M., et.al. Neoadjuvant chemoradiotherapy of stage III non-small-cell lung cancer, Lung Cancer, 2000. 30(3): p. 175-185., https://www.ncbi.nlm.nih.gov/pubmed/11137202

1034. Pottgen, C., Eberhardt, W., Grannass, A., Korfee, S., Stuben, G., Teschler, H., et.al. Prophylactic cranial irradiation in operable stage IIIA non small-cell lung cancer treated with neoadjuvant chemoradiotherapy: results from a German multicenter randomized trial, J Clin Oncol, 2007. 25(31): p. 4987-92., https://pubmed.ncbi.nlm.nih.gov/17971598/

1035. Hainsworth, JD, Waterhouse, DM, Shih, KC, Boccia, RV, Priego, VM, McCleod, MJ, et.al. Phase II trial of preoperative pemetrexed plus carboplatin in patients with stage IB-III nonsquamous non-small cell lung cancer (NSCLC)., Lung Cancer, 2018. 118 (): p. 6-12., https://pubmed.ncbi.nlm.nih.gov/29572004/

1036. Vokes, E. E., Herndon, J. E., Kelley, M. J., Cicchetti, M. G., Ramnath, N., Neill, H., et.al. Induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for regionally advanced unresectable stage III Non-small-cell lung cancer: Cancer and Leukemia Group B, J.Clin.Oncol, 2007. 25(13): p. 1698-1704., https://www.ncbi.nlm.nih.gov/pubmed/17404369

1037. De Candis, D, Stani, SC, Bidoli, P, Bedini, VA, Potepan, P, Navarria, P, et.al. Induction chemotherapy with carboplatin/paclitaxel followed by surgery or standard radiotherapy and concurrent daily low-dose cisplatin for locally advanced non-small cell lung cancer (NSCLC)., Am J Clin Oncol, 2003. 26 (3)(3): p. 265-9., https://pubmed.ncbi.nlm.nih.gov/12796598/

1038. Masters, GA, Wang, X, Hodgson, L, Shea, T, Vokes, E, Green, M, A phase II trial of high dose carboplatin and paclitaxel with G-CSF and peripheral blood stem cell support followed by surgery and/or chest radiation in patients with stage III non-small cell lung cancer: CALGB 9531., Lung Cancer, 2011. 74 (2)(2): p. 258-63., https://pubmed.ncbi.nlm.nih.gov/21529989/

1039. Chambers, A, Routledge, T, Billè, A, Scarci, M, Does surgery have a role in T4N0 and T4N1 lung cancer?, Interact Cardiovasc Thorac Surg, 2010. 11 (4)(4): p. 473-9., https://pubmed.ncbi.nlm.nih.gov/20621998/

1040. Ilonen, I, Jones, DR, Initial extended resection or neoadjuvant therapy for T4 non-small cell lung cancer-What is the evidence?, Shanghai Chest, 2018. 2 ():, https://pubmed.ncbi.nlm.nih.gov/30498811/

1041. Watanabe, S, Asamura, H, Miyaoka, E, Okumura, M, Yoshino, I, Fujii, Y, et.al. Results of T4 surgical cases in the Japanese Lung Cancer Registry Study: should mediastinal fat tissue invasion really be included in the T4 category?, J Thorac Oncol, 2013. 8 (6)(6): p. 759-65., https://pubmed.ncbi.nlm.nih.gov/23608818/

1042. Reardon, ES, Schrump, DS, Extended resections of non-small cell lung cancers invading the aorta, pulmonary artery, left atrium, or esophagus: can they be justified?, Thorac Surg Clin, 2014. 24 (4)(4): p. 457-64., https://pubmed.ncbi.nlm.nih.gov/25441139/

1043. Tsukioka, T, Takahama, M, Nakajima, R, Kimura, M, Inoue, H, Yamamoto, R, Surgical outcome of patients with lung cancer involving the left atrium., Int J Clin Oncol, 2016. 21 (6)(6): p. 1046-1050., https://pubmed.ncbi.nlm.nih.gov/27263106/

1044. Stella, F, Dell'Amore, A, Caroli, G, Dolci, G, Cassanelli, N, Luciano, G, et.al. Surgical results and long-term follow-up of T(4)-non-small cell lung cancer invading the left atrium or the intrapericardial base of the pulmonary veins., Interact Cardiovasc Thorac Surg, 2012. 14 (4)(4): p. 415-9., https://pubmed.ncbi.nlm.nih.gov/22269143/

1045. Kusumoto, H, Shintani, Y, Funaki, S, Inoue, M, Okumura, M, Kuratani, T, et.al. Combined resection of great vessels or the heart for non-small lung cancer., Ann Thorac Cardiovasc Surg, 2015. 21 (4)(4): p. 332-7., https://pubmed.ncbi.nlm.nih.gov/25740448/

1046. Langer, NB, Mercier, O, Fabre, D, Lawton, J, Mussot, S, Dartevelle, P, et.al. Outcomes After Resection of T4 Non-Small Cell Lung Cancer Using Cardiopulmonary Bypass., Ann Thorac Surg, 2016. 102 (3)(3): p. 902-910., https://pubmed.ncbi.nlm.nih.gov/27209605/

1047. Muralidaran, A, Detterbeck, FC, Boffa, DJ, Wang, Z, Kim, AW, Long-term survival after lung resection for non-small cell lung cancer with circulatory bypass: a systematic review., J Thorac Cardiovasc Surg, 2011. 142 (5)(5): p. 1137-42., https://pubmed.ncbi.nlm.nih.gov/21864854/

1048. Mody, GN, Janko, M, Vasudeva, V, Chi, JH, Davidson, MJ, Swanson, S, Thoracic Endovascular Aortic Stent Graft to Facilitate Aortic Resection During Pneumonectomy and Vertebrectomy for Locally Invasive Lung Cancer., Ann Thorac Surg, 2016. 101 (4)(4): p. 1587-9., https://pubmed.ncbi.nlm.nih.gov/27000584/

1049. Curioni-Fontecedro, A, Perentes, JY, Gelpke, H, Xyrafas, A, Bouchaab, H, Mach, N, et.al. Preoperative chemotherapy and radiotherapy concomitant to cetuximab in resectable stage IIIB NSCLC: a multicentre phase 2 trial (SAKK 16/08)., Br J Cancer, 2019. 120 (10)(10): p. 968-974., https://pubmed.ncbi.nlm.nih.gov/30988393/

1050. Guberina, N, Pöttgen, C, Schuler, M, Guberina, M, Stamatis, G, Plönes, T, et.al. Comparison of early tumour-associated versus late deaths in patients with central or >7 cm T4 N0/1 M0 non-small-cell lung-cancer undergoing trimodal treatment: Only few risks left to improve., Eur J Cancer, 2020. 138 (): p. 156-168., https://pubmed.ncbi.nlm.nih.gov/32889370/

1051. De Leyn, P, Vansteenkiste, J, Lievens, Y, Van Raemdonck, D, Nafteux, P, Decker, G, et.al. Survival after trimodality treatment for superior sulcus and central T4 non-small cell lung cancer., J Thorac Oncol, 2009. 4 (1)(1): p. 62-8., https://pubmed.ncbi.nlm.nih.gov/19096308/

1052. Lococo, F, Cesario, A, Margaritora, S, Dall'Armi, V, Nachira, D, Cusumano, G, et.al. Induction therapy followed by surgery for T3-T4/N0 non-small cell lung cancer: long-term results., Ann Thorac Surg, 2012. 93 (5)(5): p. 1633-40., https://pubmed.ncbi.nlm.nih.gov/22480394/

1053. Perentes, J, Bopp, S, Krueger, T, Gonzalez, M, Jayet, PY, Lovis, A, et.al. Impact of lung function changes after induction radiochemotherapy on resected T4 non-small cell lung cancer outcome., Ann Thorac Surg, 2012. 94 (6)(6): p. 1815-22., https://pubmed.ncbi.nlm.nih.gov/23103000/

1054. Topkan, E, Selek, U, Ozdemir, Y, Besen, AA, Guler, OC, Yildirim, BA, et.al. Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients., J Oncol, 2018. 2018 (): p. 4518935., https://pubmed.ncbi.nlm.nih.gov/30515211/

1055. Phernambucq, EC, Hartemink, KJ, Smit, EF, Paul, MA, Postmus, PE, Comans, EF, et.al. Tumor cavitation in patients with stage III non-small-cell lung cancer undergoing concurrent chemoradiotherapy: incidence and outcomes., J Thorac Oncol, 2012. 7 (8)(8): p. 1271-5., https://pubmed.ncbi.nlm.nih.gov/22659960/

1056. Ito, M, Niho, S, Nihei, K, Yoh, K, Ohmatsu, H, Ohe, Y, Risk factors associated with fatal pulmonary hemorrhage in locally advanced non-small cell lung cancer treated with chemoradiotherapy., BMC Cancer, 2012. 12 (): p. 27., https://pubmed.ncbi.nlm.nih.gov/22260460/

1057. Bradley, JD, Hu, C, Komaki, RR, Masters, GA, Blumenschein, GR, Schild, SE, et.al. Long-Term Results of NRG Oncology RTOG 0617: Standard- Versus High-Dose Chemoradiotherapy With or Without Cetuximab for Unresectable Stage III Non-Small-Cell Lung Cancer., J Clin Oncol, 2020. 38 (7)(7): p. 706-714., https://pubmed.ncbi.nlm.nih.gov/31841363/

1058. Bradley, JD, Paulus, R, Komaki, R, Masters, G, Blumenschein, G, Schild, S, et.al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study., Lancet Oncol, 2015. 16 (2)(2): p. 187-99., https://pubmed.ncbi.nlm.nih.gov/25601342/

1059. Pöttgen, C, Stuschke, M, Graupner, B, Theegarten, D, Gauler, T, Jendrossek, V, et.al. Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors., BMC Cancer, 2015. 15 (): p. 363., https://pubmed.ncbi.nlm.nih.gov/25943191/

1060. Chen, Y, Peng, X, Zhou, Y, Xia, K, Zhuang, W, Comparing the benefits of chemoradiotherapy and chemotherapy for resectable stage III A/N2 non-small cell lung cancer: a meta-analysis., World J Surg Oncol, 2018. 16 (1)(1): p. 8., https://pubmed.ncbi.nlm.nih.gov/29338734/

1061. Cerfolio, RJ, Bryant, AS, Jones, VL, Cerfolio, RM, Pulmonary resection after concurrent chemotherapy and high dose (60Gy) radiation for non-small cell lung cancer is safe and may provide increased survival., Eur J Cardiothorac Surg, 2009. 35 (4)(4): p. 718-23; discussion 723., https://pubmed.ncbi.nlm.nih.gov/19233668/

1062. Suntharalingam, M, Paulus, R, Edelman, MJ, Krasna, M, Burrows, W, Gore, E, et.al. Radiation therapy oncology group protocol 02-29: a phase II trial of neoadjuvant therapy with concurrent chemotherapy and full-dose radiation therapy followed by surgical resection and consolidative therapy for locally advanced non-small cell carcinoma of the lung., Int J Radiat Oncol Biol Phys, 2012. 84 (2)(2): p. 456-63., https://pubmed.ncbi.nlm.nih.gov/22543206/

1063. Wakelee, H, Liberman, M, Kato, T, Tsuboi, M, Lee, SH, Gao, S, et.al. Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer., N Engl J Med, 2023. 389 (6)(6): p. 491-503., https://pubmed.ncbi.nlm.nih.gov/37272513/

1064. Mitsudomi, T, Heymach, JV, Reck, M, Taube, JM, Gao, S, Horio, Y, et.al. Surgical Outcomes With Neoadjuvant Durvalumab Plus Chemotherapy Followed by Adjuvant Durvalumab in Resectable NSCLC., J Thorac Oncol, 2025. 20 (11)(11): p. 1639-1654., https://pubmed.ncbi.nlm.nih.gov/40545237/

1065. Liberman, M, Jones, DR, Wakelee, H, Gao, S, Halmos, B, Nadal, E, et.al. Clinical Characteristics and Surgical Outcomes of Patients Receiving Perioperative Pembrolizumab in KEYNOTE-671., Ann Thorac Surg, 2026. 121 (2)(2): p. 281-289., https://pubmed.ncbi.nlm.nih.gov/41203001/

1066. Guberina, M, Metzenmacher, M, Pöttgen, C, Wiesweg, M, Guberina, N, Merkel-Jens, A, et.al. Pathologic Complete Response Predicts Long-Term Survival Following Neoadjuvant Induction Chemotherapy and Chemo-Radiotherapy in Stage-III Non-Small Cell Lung Cancer., Thorac Cancer, 2025. 16 (22)(22): p. e70183., https://pubmed.ncbi.nlm.nih.gov/41261778/

1067. Hamada, A, Soh, J, Hata, A, Nakamatsu, K, Shimokawa, M, Yatabe, Y, et.al. Neoadjuvant Concurrent Chemo-Immuno-Radiation Therapy Followed by Surgery and Adjuvant Immunotherapy for Resectable Stage III N2 NSCLC: Primary Results From the SQUAT Trial (WJOG 12119L)., J Thorac Oncol, 2025. 20 (8)(8): p. 1098-1107., https://pubmed.ncbi.nlm.nih.gov/40216327/

1068. Topkan, E, Selek, U, Ozdemir, Y, Yildirim, BA, Guler, OC, Ciner, F, et.al. Incidence and Impact of Pretreatment Tumor Cavitation on Survival Outcomes of Stage III Squamous Cell Lung Cancer Patients Treated With Radical Concurrent Chemoradiation Therapy., Int J Radiat Oncol Biol Phys, 2018. 101 (5)(5): p. 1123-1132., https://pubmed.ncbi.nlm.nih.gov/29887509/

1069. Hino, H, Utsumi, T, Maru, N, Matsui, H, Taniguchi, Y, Saito, T, et.al. Results of emergency salvage lung resection after chemo- and/or radiotherapy among patients with lung cancer., Interact Cardiovasc Thorac Surg, 2022. 35 (1)(1):, https://pubmed.ncbi.nlm.nih.gov/35253874/

1070. Yamanashi, K, Okumura, N, Takahashi, A, Nakashima, T, Matsuoka, T, Surgical and survival outcomes of lung cancer patients with intratumoral lung abscesses., J Cardiothorac Surg, 2017. 12 (1)(1): p. 44., https://pubmed.ncbi.nlm.nih.gov/28549477/

1071. Li, Y, Tang, Y, Li, X, Li, J, Recovery of temperature to normal may indicate the best time for surgery in patients with lung cancer complicated by a lung abscess: A case report., Oncol Lett, 2024. 28 (6)(6): p. 608., https://pubmed.ncbi.nlm.nih.gov/39525608/

1072. Lobinger, D, Hiebinger, A, Eicher, F, Groß, G, Shalabi, I, Reiche, A, et.al. Rescue surgery in palliative indication as last therapeutic option for complicated advanced stage lung cancer., Eur J Surg Oncol, 2023. 49 (12)(12): p. 107253., https://pubmed.ncbi.nlm.nih.gov/37944369/

1073. Leonardi, B, Messina, G, Vicario, G, Pica, DG, Di Filippo, V, Vinciguerra, R, et.al. Rescue Surgery for Advanced Stage Lung Cancer: A Systematic Review., Thorac Cancer, 2025. 16 (16)(16): p. e70151., https://pubmed.ncbi.nlm.nih.gov/40836713/

1074. Auperin, A., Le Pechoux, C., Rolland, E., Curran, W. J., Furuse, K., Fournel, P., et.al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer, J Clin Oncol, 2010. 28(13): p. 2181-90., https://www.ncbi.nlm.nih.gov/pubmed/20351327

1075. Xiao, W, Hong, M, Concurrent vs sequential chemoradiotherapy for patients with advanced non-small-cell lung cancer: A meta-analysis of randomized controlled trials., Medicine (Baltimore), 2021. 100 (11)(11): p. e21455., https://pubmed.ncbi.nlm.nih.gov/33725921/

1076. Flentje, M, Huber, RM, Engel-Riedel, W, Andreas, S, Kollmeier, J, Staar, S, et.al. GILT--A randomised phase III study of oral vinorelbine and cisplatin with concomitant radiotherapy followed by either consolidation therapy with oral vinorelbine and cisplatin or best supportive care alone in stage III non-small cell lung cancer., Strahlenther Onkol, 2016. 192 (4)(4): p. 216-22., https://pubmed.ncbi.nlm.nih.gov/26809652/

1077. Nestle, U, Schimek-Jasch, T, Kremp, S, Schaefer-Schuler, A, Mix, M, Küsters, A, et.al. Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial., Lancet Oncol, 2020. 21 (4)(4): p. 581-592., https://pubmed.ncbi.nlm.nih.gov/32171429/

1078. Fournel, P., Robinet, G., Thomas, P., Souquet, P. J., Lena, H., Vergnenegre, A., et.al. Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Francais de Pneumo-Cancerologie NPC 95-01 Study, J Clin Oncol, 2005. 23(25): p. 5910-5917., https://www.ncbi.nlm.nih.gov/pubmed/16087956

1079. Furuse, K., Fukuoka, M., Kawahara, M., Nishikawa, H., Takada, Y., Kudoh, S., et.al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer, J Clin Oncol, 1999. 17(9): p. 2692-2699., https://www.ncbi.nlm.nih.gov/pubmed/10561343

1080. Curran, WJ, Paulus, R, Langer, CJ, Komaki, R, Lee, JS, Hauser, S, et.al. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410., J Natl Cancer Inst, 2011. 103 (19)(19): p. 1452-60., https://pubmed.ncbi.nlm.nih.gov/21903745/

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1129. Provencio, M, Campos, B, Guirado, M, Vila, L, García Campelo, R, Dorta, M, et.al. Induction chemo-immunotherapy followed by chemo-radiotherapy and immunotherapy maintenance in stage III NSCLC (APOLO): a phase 2 trial., Nat Commun, 2025. 16 (1)(1): p. 10124., https://pubmed.ncbi.nlm.nih.gov/41436730/

1130. Filippi, AR, Agustoni, F, Arcangeli, S, Cortinovis, D, Ferrari, A, Cicognini, D, et.al. Rationale and Design of a Single-Arm, Phase 2, Multi-Center Study of Chemo-Immunotherapy Followed by Hypo-Fractionated RT and Maintenance Immunotherapy in Patients With Unresectable Stage III NSCLC: The DEDALUS Trial., Clin Lung Cancer, 2023. 24 (3)(3): p. e122-e125., https://pubmed.ncbi.nlm.nih.gov/36759266/

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1145. Paz-Ares, L, Ciuleanu, TE, Cobo, M, Schenker, M, Zurawski, B, Menezes, J, et.al. First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial., Lancet Oncol, 2021. 22 (2)(2): p. 198-211., https://pubmed.ncbi.nlm.nih.gov/33476593/

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1147. Reck, M, Rodríguez-Abreu, D, Robinson, AG, Hui, R, Csőszi, T, Fülöp, A, et.al. Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater., J Clin Oncol, 2019. 37 (7)(7): p. 537-546., https://pubmed.ncbi.nlm.nih.gov/30620668/

1148. Herbst, RS, Giaccone, G, de Marinis, F, Reinmuth, N, Vergnenegre, A, Barrios, CH, et.al. Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC., N Engl J Med, 2020. 383 (14)(14): p. 1328-1339., https://pubmed.ncbi.nlm.nih.gov/32997907/

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1373. Gadgeel, Shirish M., Shaw, Alice T., Govindan, Ramaswamy, Gandhi, Leena, Socinski, Mark A., Camidge, D. Ross, et.al. Pooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non–Small-Cell Lung Cancer, Journal of Clinical Oncology, 2016. 34(34): p. 4079-4085., https://doi.org/10.1200/JCO.2016.68.4639

1374. Kim, Dong-Wan, Tiseo, Marcello, Ahn, Myung-Ju, Reckamp, Karen L., Hansen, Karin Holmskov, Kim, Sang-We, et.al. Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase–Positive Non–Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial, Journal of Clinical Oncology, 2017. 35(22): p. 2490-2498., https://doi.org/10.1200/JCO.2016.71.5904

1375. Gettinger, S. N., Bazhenova, L. A., Langer, C. J., Salgia, R., Gold, K. A., Rosell, R., et.al. Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: a single-arm, open-label, phase 1/2 trial, Lancet Oncol, 2016. 17(12): p. 1683-1696., https://www.ncbi.nlm.nih.gov/pubmed/27836716

1376. Shaw, A. T., Kim, T. M., Crino, L., Gridelli, C., Kiura, K., Liu, G., et.al. Ceritinib versus chemotherapy in patients with ALK-rearranged non-small-cell lung cancer previously given chemotherapy and crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial, Lancet Oncol, 2017. 18(7): p. 874-886., https://www.ncbi.nlm.nih.gov/pubmed/28602779

1377. Kim, D. W., Mehra, R., Tan, D. S. W., Felip, E., Chow, L. Q. M., Camidge, D. R., et.al. Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial, Lancet Oncol, 2016. 17(4): p. 452-463., https://pubmed.ncbi.nlm.nih.gov/26973324/

1378. Shaw, A. T., Solomon, B. J., Besse, B., Bauer, T. M., Lin, C. C., Soo, R. A., et.al. ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer, J Clin Oncol, 2019. 37(16): p. 1370-1379., https://pubmed.ncbi.nlm.nih.gov/30892989/

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1387. Michels, S, Massutí, B, Schildhaus, HU, Franklin, J, Sebastian, M, Felip, E, et.al. Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial., J Thorac Oncol, 2019. 14 (7)(7): p. 1266-1276., https://pubmed.ncbi.nlm.nih.gov/30978502/

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1389. Drilon, A, Camidge, DR, Lin, JJ, Kim, SW, Solomon, BJ, Dziadziuszko, R, et.al. Repotrectinib in , N Engl J Med, 2024. 390 (2)(2): p. 118-131., https://pubmed.ncbi.nlm.nih.gov/38197815/

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1394. Cho, Byoung Chul, Drilon, Alexander E., Doebele, Robert Charles, Kim, Dong-Wan, Lin, Jessica Jiyeong, Lee, Jeeyun, et.al. Safety and preliminary clinical activity of repotrectinib in patients with advanced ROS1 fusion-positive non-small cell lung cancer (TRIDENT-1 study), Journal of Clinical Oncology, 2019. 37(15_suppl): p. 9011-9011., https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9011

1395. Solomon, B. J., Martini, J. F., Ou, S. H. I., Chiari, R., Soo, R. A., Bearz, A., et.al. Efficacy of lorlatinib in patients (pts) with ROS1-positive advanced non-small cell lung cancer (NSCLC) and ROS1 kinase domain mutations, Annals of Oncology, 2018. 29: p. viii495., https://doi.org/10.1093/annonc/mdy292.003

1396. Shaw, AT, Solomon, BJ, Chiari, R, Riely, GJ, Besse, B, Soo, RA, et.al. Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1-2 trial., Lancet Oncol, 2019. 20 (12)(12): p. 1691-1701., https://pubmed.ncbi.nlm.nih.gov/31669155/

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1404. Ng, TL, Smith, DE, Mushtaq, R, Patil, T, Dimou, A, Yang, S, et.al. ROS1 Gene Rearrangements Are Associated With an Elevated Risk of Peridiagnosis Thromboembolic Events., J Thorac Oncol, 2019. 14 (4)(4): p. 596-605., https://pubmed.ncbi.nlm.nih.gov/30543838/

1405. Planchard, D, Smit, EF, Groen, HJM, Mazieres, J, Besse, B, Helland, Å, et.al. Dabrafenib plus trametinib in patients with previously untreated BRAF, Lancet Oncol, 2017. 18 (10)(10): p. 1307-1316., https://pubmed.ncbi.nlm.nih.gov/28919011/

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1411. Drilon, A, Laetsch, TW, Kummar, S, DuBois, SG, Lassen, UN, Demetri, GD, et.al. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children., N Engl J Med, 2018. 378 (8)(8): p. 731-739., https://pubmed.ncbi.nlm.nih.gov/29466156/

1412. Drilon, A, Oxnard, GR, Tan, DSW, Loong, HHF, Johnson, M, Gainor, J, et.al. Efficacy of Selpercatinib in , N Engl J Med, 2020. 383 (9)(9): p. 813-824., https://pubmed.ncbi.nlm.nih.gov/32846060/

1413. Doebele, R. C., Drilon, A., Paz-Ares, L., Siena, S., Shaw, A. T., Farago, A. F., et.al. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials, Lancet Oncol, 2020. 21(2): p. 271-282., https://pubmed.ncbi.nlm.nih.gov/31838007/

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1415. Besse, Benjamin, Lin, Jessica J., Bazhenova, Lyudmila, Goto, Koichi, de Langen, Adrianus Johannes, Kim, Dong-Wan, et.al. Repotrectinib in NTRK fusion–positive advanced solid tumors: a phase 1/2 trial, 2026. 32(2): p. 682 - 689., https://doi.org/10.1038/s41591-025-04079-7

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1419. Gainor, Justin F., Lee, Dae Ho, Curigliano, Giuseppe, Doebele, Robert Charles, Kim, Dong-Wan, Baik, Christina S, et.al. Clinical activity and tolerability of BLU-667, a highly potent and selective RET inhibitor, in patients (pts) with advanced RET-fusion+ non-small cell lung cancer (NSCLC), Journal of Clinical Oncology, 2019. 37(15_suppl): p. 9008-9008., https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9008

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