Leitlinienprogramm OnkologieKomplementärmedizin

14. Literaturverzeichnis – Komplementärmedizin

Version 2.0 · Mai 2024 · AWMF 032-055OL
Leitlinienprogramm Onkologie · Deutsche Krebsgesellschaft · Deutsche Krebshilfe · AWMF

1. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften - Ständige Kommission, Leitlinien, AWMF-Regelwerk "Leitlinien", 1. Auflage 2012. 09.12.2013:, https://www.awmf.org/regelwerk/

2. Hack, CC, Hüttner, NB, Fasching, PA, Beckmann, MW, Development and Validation of a Standardized Questionnaire and Standardized Diary for Use in Integrative Medicine Consultations in Gynecologic Oncology., Geburtshilfe Frauenheilkd, 2015. 75 (4)(4): p. 377-383., https://pubmed.ncbi.nlm.nih.gov/26028695/

3. Huebner, J, Muenstedt, K, Muecke, R, Micke, O, Stoll, C, Kleeberg, UR, et.al. Counseling cancer patients on complementary and alternative medicine, Strahlentherapie und Onkologie, 2013. 189(8): p. 613-617., https://pubmed.ncbi.nlm.nih.gov/23824107/

4. Huebner, J., Micke, O., Muecke, R., Buentzel, J., Prott, F. J., Kleeberg, U., et.al. User rate of complementary and alternative medicine (CAM) of patients visiting a counseling facility for CAM of a German comprehensive cancer center, Anticancer Res, 2014. 34(2): p. 943-8., https://www.ncbi.nlm.nih.gov/pubmed/24511037

5. Micke, Oliver, Bruns, Frank, Glatzel, Michael, Schönekaes, Klaus, Micke, Patrick, Mücke, Ralph, et.al. Predictive factors for the use of complementary and alternative medicine (CAM) in radiation oncology, European Journal of Integrative Medicine, 2009. 1(1): p. 19-25., https://doi.org/10.1016/j.eujim.2009.02.001

6. Molassiotis, Alexander, Fernandez-Ortega, Paz, Pud, Dorit, Ozden, Gulten, Scott, Julia A, Panteli, Vassiliki, et.al. Use of complementary and alternative medicine in cancer patients: a European survey, Annals of oncology, 2005. 16(4): p. 655-663., https://pubmed.ncbi.nlm.nih.gov/15699021/

7. Lücking, Elisabeth, Und welche Internetseite empfehlen Sie Ihren Patienten?, 2019. 2020:, https://www.aekno.de/aerzte/rheinisches-aerzteblatt/ausgabe/artikel/2019/03-2019/und-welche-internetseite-empfehlen-sie-ihren-patienten

8. Sänger, Sylvia, Lang, Britta, Klemperer, David, Thomeczek, Christian, Dierks, Marie-Luise, Manual Patienteninformation–Empfehlungen zur Erstellung evidenzbasierter Patienteninformationen, ÄZQ, Berlin, 2006., https://www.researchgate.net/publication/331862104_Manual_Patienteninformation_Empfehlung_zur_Erstellung_evidenzbasierter_Patienteninformationen

9. Rogge, A. A., Baur, I., Blettner, G., Holtkamp, U., Horneber, M., Jahn, P., et.al. Defining Criteria for Guiding Cancer Patients to Find a Reputable Complementary Medicine Provider: Results of a Literature Review and a Consensus Procedure, Patient Prefer Adherence, 2020. 14: p. 747-755., https://www.ncbi.nlm.nih.gov/pubmed/32368016

10. Witt, Claudia M, Balneaves, Lynda G, Carlson, Linda E, Cohen, Misha, Deng, Gary, Fouladbakhsh, Judith M, et.al. Education Competencies for Integrative Oncology—Results of a Systematic Review and an International and Interprofessional Consensus Procedure, Journal of Cancer Education, 2020. p. 1-9.

11. Witt, Claudia M, Helmer, Stefanie M, Schofield, Penelope, Wastell, Marisa, Canella, Claudia, Thomae, Anita V, et.al. Training oncology physicians to advise their patients on complementary and integrative medicine: An implementation study for a manual‐guided consultation, Cancer, 2020., https://pubmed.ncbi.nlm.nih.gov/32286693/

12. Garcia, M. K., McQuade, J., Haddad, R., Patel, S., Lee, R., Yang, P., et.al. Systematic review of acupuncture in cancer care: a synthesis of the evidence, J Clin Oncol, 2013. 31(7): p. 952-60., https://www.ncbi.nlm.nih.gov/pubmed/23341529

13. Rithirangsriroj, K., Manchana, T., Akkayagorn, L., Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients, Gynecol Oncol, 2015. 136(1): p. 82-6., https://www.ncbi.nlm.nih.gov/pubmed/25449310

14. Zhou, J., Fang, L., Wu, W. Y., He, F., Zhang, X. L., Zhou, X., et.al. The effect of acupuncture on chemotherapy-associated gastrointestinal symptoms in gastric cancer, Curr Oncol, 2017. 24(1): p. e1-e5., https://www.ncbi.nlm.nih.gov/pubmed/28270726

15. Enblom, A., Johnsson, A., Hammar, M., Onelov, E., Steineck, G., Borjeson, S., Acupuncture compared with placebo acupuncture in radiotherapy-induced nausea--a randomized controlled study, Ann Oncol, 2012. 23(5): p. 1353-1361., https://www.ncbi.nlm.nih.gov/pubmed/21948812

16. Pan, Y., Yang, K., Shi, X., Liang, H., Shen, X., Wang, R., et.al. Clinical Benefits of Acupuncture for the Reduction of Hormone Therapy-Related Side Effects in Breast Cancer Patients: A Systematic Review, Integr Cancer Ther, 2018. 17(3): p. 602-618., https://www.ncbi.nlm.nih.gov/pubmed/30117343

17. Hervik, J. B., Stub, T., Adverse effects of non-hormonal pharmacological interventions in breast cancer survivors, suffering from hot flashes: A systematic review and meta-analysis, Breast Cancer Res Treat, 2016. 160(2): p. 223-236., https://www.ncbi.nlm.nih.gov/pubmed/27709351

18. Lesi, G., Razzini, G., Musti, M. A., Stivanello, E., Petrucci, C., Benedetti, B., et.al. Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women With Breast Cancer: A Prospective Multicenter Randomized Controlled Trial (AcCliMaT), J Clin Oncol, 2016. 34(15): p. 1795-802., https://www.ncbi.nlm.nih.gov/pubmed/27022113

19. Walker, E. M., Rodriguez, A. I., Kohn, B., Ball, R. M., Pegg, J., Pocock, J. R., et.al. Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial, J Clin Oncol, 2010. 28(4): p. 634-40., https://www.ncbi.nlm.nih.gov/pubmed/20038728

20. Bokmand, S., Flyger, H., Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study, Breast, 2013. 22(3): p. 320-3., https://www.ncbi.nlm.nih.gov/pubmed/22906948

21. Frisk, J., Kallstrom, A. C., Wall, N., Fredrikson, M., Hammar, M., Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes, Support Care Cancer, 2012. 20(4): p. 715-24., https://www.ncbi.nlm.nih.gov/pubmed/21468626

22. Chen, L., Lin, C. C., Huang, T. W., Kuan, Y. C., Huang, Y. H., Chen, H. C., et.al. Effect of acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer: A meta-analysis of randomized controlled trials, Breast, 2017. 33: p. 132-138., https://www.ncbi.nlm.nih.gov/pubmed/28384564

23. Chiu, H. Y., Hsieh, Y. J., Tsai, P. S., Systematic review and meta-analysis of acupuncture to reduce cancer-related pain, Eur J Cancer Care (Engl), 2017. 26(2): p. 1-17., https://www.ncbi.nlm.nih.gov/pubmed/26853524

24. Hershman, D. L., Unger, J. M., Greenlee, H., Capodice, J. L., Lew, D. L., Darke, A. K., et.al. Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer: A Randomized Clinical Trial, JAMA, 2018. 320(2): p. 167-176., https://www.ncbi.nlm.nih.gov/pubmed/29998338

25. He, Y., Guo, X., May, B. H., Zhang, A. L., Liu, Y., Lu, C., et.al. Clinical Evidence for Association of Acupuncture and Acupressure With Improved Cancer Pain: A Systematic Review and Meta-Analysis, JAMA Oncol, 2020. 6(2): p. 271-278., https://www.ncbi.nlm.nih.gov/pubmed/31855257

26. Paley, C. A., Johnson, M. I., Tashani, O. A., Bagnall, A. M., Acupuncture for cancer pain in adults, Cochrane Database Syst Rev, 2015. p. CD007753., https://www.ncbi.nlm.nih.gov/pubmed/26468973

27. Ntritsou, V., Mavrommatis, C., Kostoglou, C., Dimitriadis, G., Tziris, N., Zagka, P., et.al. Effect of perioperative electroacupuncture as an adjunctive therapy on postoperative analgesia with tramadol and ketamine in prostatectomy: a randomised sham-controlled single-blind trial, Acupunct Med, 2014. 32(3): p. 215-22., https://www.ncbi.nlm.nih.gov/pubmed/24480836

28. An, L. X., Chen, X., Ren, X. J., Wu, H. F., Electro-acupuncture decreases postoperative pain and improves recovery in patients undergoing a supratentorial craniotomy, Am J Chin Med, 2014. 42(5): p. 1099-109., https://www.ncbi.nlm.nih.gov/pubmed/25169910

29. Ju, Z. Y., Wang, K., Cui, H. S., Yao, Y., Liu, S. M., Zhou, J., et.al. Acupuncture for neuropathic pain in adults, Cochrane Database Syst Rev, 2017. 12(12): p. CD012057., https://www.ncbi.nlm.nih.gov/pubmed/29197180

30. Greenlee, H., Crew, K. D., Capodice, J., Awad, D., Buono, D., Shi, Z., et.al. Randomized sham-controlled pilot trial of weekly electro-acupuncture for the prevention of taxane-induced peripheral neuropathy in women with early stage breast cancer, Breast Cancer Res Treat, 2016. 156(3): p. 453-464., https://www.ncbi.nlm.nih.gov/pubmed/27013473

31. Molassiotis, A., Suen, L. K. P., Cheng, H. L., Mok, T. S. K., Lee, S. C. Y., Wang, C. H., et.al. A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy, Integr Cancer Ther, 2019. 18: p. 1534735419836501., https://www.ncbi.nlm.nih.gov/pubmed/30905173

32. Garland, S. N., Xie, S. X., DuHamel, K., Bao, T., Li, Q., Barg, F. K., et.al. Acupuncture Versus Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: A Randomized Clinical Trial, J Natl Cancer Inst, 2019. 111(12): p. 1323-1331., https://www.ncbi.nlm.nih.gov/pubmed/31081899

33. Brinkhaus, B., Kirschbaum, B., Stockigt, B., Binting, S., Roll, S., Carstensen, M., et.al. Prophylactic acupuncture treatment during chemotherapy with breast cancer: a randomized pragmatic trial with a retrospective nested qualitative study, Breast Cancer Res Treat, 2019. 178(3): p. 617-628., https://www.ncbi.nlm.nih.gov/pubmed/31520284

34. Zeng, Y., Luo, T., Finnegan-John, J., Cheng, A. S., Meta-Analysis of Randomized Controlled Trials of Acupuncture for Cancer-Related Fatigue, Integr Cancer Ther, 2014. 13(3): p. 193-200., https://www.ncbi.nlm.nih.gov/pubmed/24282102

35. Deng, G., Chan, Y., Sjoberg, D., Vickers, A., Yeung, K. S., Kris, M., et.al. Acupuncture for the treatment of post-chemotherapy chronic fatigue: a randomized, blinded, sham-controlled trial, Support Care Cancer, 2013. 21(6): p. 1735-41., https://www.ncbi.nlm.nih.gov/pubmed/23334562

36. Choi, T. Y., Kim, J. I., Lim, H. J., Lee, M. S., Acupuncture for Managing Cancer-Related Insomnia: A Systematic Review of Randomized Clinical Trials, Integr Cancer Ther, 2017. 16(2): p. 135-146., https://www.ncbi.nlm.nih.gov/pubmed/27531549

37. Garland, S. N., Xie, S. X., Li, Q., Seluzicki, C., Basal, C., Mao, J. J., Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial, Menopause, 2017. 24(5): p. 517-523., https://www.ncbi.nlm.nih.gov/pubmed/27875389

38. Assy, Z., Brand, H. S., A systematic review of the effects of acupuncture on xerostomia and hyposalivation, BMC Complement Altern Med, 2018. 18(1): p. 57., https://www.ncbi.nlm.nih.gov/pubmed/29439690

39. Furness, S., Bryan, G., McMillan, R., Worthington, H. V., Interventions for the management of dry mouth: Nonpharmacological interventions, Cochrane Database of Systematic Reviews, 2013. 2013(8):, https://pubmed.ncbi.nlm.nih.gov/23996155/

40. Liu, Y. H., Dong, G. T., Ye, Y., Zheng, J. B., Zhang, Y., Lin, H. S., et.al. Effectiveness of Acupuncture for Early Recovery of Bowel Function in Cancer: A Systematic Review and Meta-Analysis, Evid Based Complement Alternat Med, 2017. 2017: p. 2504021., https://www.ncbi.nlm.nih.gov/pubmed/29422935

41. Jung, S. Y., Chae, H. D., Kang, U. R., Kwak, M. A., Kim, I. H., Effect of Acupuncture on Postoperative Ileus after Distal Gastrectomy for Gastric Cancer, J Gastric Cancer, 2017. 17(1): p. 11-20., https://www.ncbi.nlm.nih.gov/pubmed/28337359

42. You, X., Wang, Y., Wu, J., Liu, Q., Liu, Y., Qian, Y., et.al. Zusanli (ST36) Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus following Radical Gastrectomy for Gastric Cancer: a Randomized Clinical Trial, J Cancer, 2018. 9(13): p. 2266-2274., https://www.ncbi.nlm.nih.gov/pubmed/30026821

43. Zhao, Jiaying, Cai, Yuankun, Wang, Huipeng, Zhou, Yan, Zhang, Yanbin, Chen, Wenjie, et.al. Comparison of Pelvic Autonomic Nerve Function Recovery Between the Group only with Surgery and Group with Additional Acupuncture and Electrotherapy for Treatment in Patients with Rectal Cancer after Anus-Preserving Operation, Acupuncture & Electro-Therapeutics Research, 2018. 43(2): p. 103-118., https://doi.org/10.3727/036012918X15353852193131

44. Tong, T., Pei, C., Chen, J., Lv, Q., Zhang, F., Cheng, Z., Efficacy of Acupuncture Therapy for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients, Med Sci Monit, 2018. 24: p. 2919-2927., https://www.ncbi.nlm.nih.gov/pubmed/29735975

45. Pan-Weisz, T. M., Kryza-Lacombe, M., Burkeen, J., Hattangadi-Gluth, J., Malcarne, V. L., McDonald, C. R., Patient-reported health-related quality of life outcomes in supportive-care interventions for adults with brain tumors: A systematic review, Psychooncology, 2019. 28(1): p. 11-21., https://www.ncbi.nlm.nih.gov/pubmed/30280453

46. Molassiotis, A., Bardy, J., Finnegan-John, J., Mackereth, P., Ryder, D. W., Filshie, J., et.al. Acupuncture for cancer-related fatigue in patients with breast cancer: a pragmatic randomized controlled trial, J Clin Oncol, 2012. 30(36): p. 4470-6., https://www.ncbi.nlm.nih.gov/pubmed/23109700

47. Minchom, A., Punwani, R., Filshie, J., Bhosle, J., Nimako, K., Myerson, J., et.al. A randomised study comparing the effectiveness of acupuncture or morphine versus the combination for the relief of dyspnoea in patients with advanced non-small cell lung cancer and mesothelioma, Eur J Cancer, 2016. 61: p. 102-10., https://www.ncbi.nlm.nih.gov/pubmed/27156228

48. Mao, J. J., Farrar, J. T., Bruner, D., Zee, J., Bowman, M., Seluzicki, C., et.al. Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: a randomized trial, Cancer, 2014. 120(23): p. 3744-51., https://www.ncbi.nlm.nih.gov/pubmed/25077452

49. Bao, T., Cai, L., Snyder, C., Betts, K., Tarpinian, K., Gould, J., et.al. Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms, Cancer, 2014. 120(3): p. 381-9., https://www.ncbi.nlm.nih.gov/pubmed/24375332

50. Deng, G., Giralt, S., Chung, D. J., Landau, H., Siman, J., Search, B., et.al. Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial, Support Care Cancer, 2018. 26(2): p. 657-665., https://www.ncbi.nlm.nih.gov/pubmed/28920142

51. Deng, G., Giralt, S., Chung, D. J., Landau, H., Siman, J., Li, Q. S., et.al. Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial, Pain Med, 2020. 21(3): p. 636-642., https://www.ncbi.nlm.nih.gov/pubmed/31498394

52. Wang, N., Ou, Y., Qing, W., Combined acupuncture and general anesthesia on immune and cognitive function in elderly patients following subtotal gastrectomy for gastric cancer, Oncol Lett, 2018. 15(1): p. 189-194., https://www.ncbi.nlm.nih.gov/pubmed/29391879

53. Feng, Y., Wang, X. Y., Li, S. D., Zhang, Y., Wang, H. M., Li, M., et.al. Clinical research of acupuncture on malignant tumor patients for improving depression and sleep quality, J Tradit Chin Med, 2011. 31(3): p. 199-202., https://www.ncbi.nlm.nih.gov/pubmed/21977863

54. Hu, Y. Q., Wu, Y. F., Hou, L. L., The Effectiveness of Electrical Acupuncture Stimulation in Reducing Levels of Self-reported Anxiety of Lung Cancer Patients during Palliative Care: A Pilot Study, Iran J Public Health, 2017. 46(8): p. 1054-1061., https://www.ncbi.nlm.nih.gov/pubmed/28894706

55. Yang, Zhen-jie, Xiao, Xue-wei, Effect of acupuncture plus medium-frequency electric stimulation on bladder function after radical hysterectomy for cervical cancer, Journal of Acupuncture and Tuina Science, 2017. 15(5): p. 371-376., https://doi.org/10.1007/s11726-017-1030-y

56. Chien, T. J., Liu, C. Y., Fang, C. J., The Effect of Acupuncture in Breast Cancer-Related Lymphoedema (BCRL): A Systematic Review and Meta-Analysis, Integr Cancer Ther, 2019. 18: p. 1534735419866910., https://www.ncbi.nlm.nih.gov/pubmed/31387468

57. Ben-Aharon, I., Gafter-Gvili, A., Paul, M., Leibovici, L., Stemmer, S. M., Interventions for alleviating cancer-related dyspnea: a systematic review, J Clin Oncol, 2008. 26(14): p. 2396-404., https://www.ncbi.nlm.nih.gov/pubmed/18467732

58. Miao, J., Liu, X., Wu, C., Kong, H., Xie, W., Liu, K., Effects of acupressure on chemotherapy-induced nausea and vomiting-a systematic review with meta-analyses and trial sequential analysis of randomized controlled trials, Int J Nurs Stud, 2017. 70: p. 27-37., https://www.ncbi.nlm.nih.gov/pubmed/28231440

59. Genc, A., Can, G., Aydiner, A., The efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting, Support Care Cancer, 2013. 21(1): p. 253-61., https://www.ncbi.nlm.nih.gov/pubmed/22678407

60. Hsiung, W. T., Chang, Y. C., Yeh, M. L., Chang, Y. H., Acupressure improves the postoperative comfort of gastric cancer patients: A randomised controlled trial, Complement Ther Med, 2015. 23(3): p. 339-46., https://www.ncbi.nlm.nih.gov/pubmed/26051568

61. Kong, C., Han, M., Zhang, C., Zhao, Z., Fang, F., Zhang, Z., et.al. Auricular point acupressure improved nausea, vomiting, diarrhea and nutritional status in gastric cancer patients receiving oral s-1 therapy, International journal of clinical and experimental medicine, 2018. 11(9): p. 9200‐., https://e-century.us/files/ijcem/11/9/ijcem0068778.pdf

62. Roscoe, J. A., Bushunow, P., Jean-Pierre, P., Heckler, C. E., Purnell, J. Q., Peppone, L. J., et.al. Acupressure bands are effective in reducing radiation therapy-related nausea, J Pain Symptom Manage, 2009. 38(3): p. 381-9., https://www.ncbi.nlm.nih.gov/pubmed/19328650

63. Duong, N., Davis, H., Robinson, P. D., Oberoi, S., Cataudella, D., Culos-Reed, S. N., et.al. Mind and body practices for fatigue reduction in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis, Crit Rev Oncol Hematol, 2017. 120: p. 210-216., https://www.ncbi.nlm.nih.gov/pubmed/29198334

64. Khanghah, A. G., Rizi, M. S., Nabi, B. N., Adib, M., Leili, E. K. N., Effects of Acupressure on Fatigue in Patients with Cancer Who Underwent Chemotherapy, J Acupunct Meridian Stud, 2019. 12(4): p. 103-110., https://www.ncbi.nlm.nih.gov/pubmed/31351998

65. Beikmoradi, A., Najafi, F., Roshanaei, G., Pour Esmaeil, Z., Khatibian, M., Ahmadi, A., Acupressure and anxiety in cancer patients, Iran Red Crescent Med J, 2015. 17(3): p. e25919., https://www.ncbi.nlm.nih.gov/pubmed/26019908

66. Molassiotis, A., Russell, W., Hughes, J., Breckons, M., Lloyd-Williams, M., Richardson, J., et.al. The effectiveness of acupressure for the control and management of chemotherapy-related acute and delayed nausea: a randomized controlled trial, J Pain Symptom Manage, 2014. 47(1): p. 12-25., https://www.ncbi.nlm.nih.gov/pubmed/23602325

67. Sharifi Rizi, M., Shamsalinia, A., Ghaffari, F., Keyhanian, S., Naderi Nabi, B., The effect of acupressure on pain, anxiety, and the physiological indexes of patients with cancer undergoing bone marrow biopsy, Complement Ther Clin Pract, 2017. 29: p. 136-141., https://www.ncbi.nlm.nih.gov/pubmed/29122251

68. Zick, S. M., Sen, A., Hassett, A. L., Schrepf, A., Wyatt, G. K., Murphy, S. L., et.al. Impact of Self-Acupressure on Co-Occurring Symptoms in Cancer Survivors, JNCI Cancer Spectr, 2018. 2(4): p. pky064., https://www.ncbi.nlm.nih.gov/pubmed/30687806

69. Shin, J., Park, H., Effects of Auricular Acupressure on Constipation in Patients With Breast Cancer Receiving Chemotherapy: A Randomized Control Trial, West J Nurs Res, 2018. 40(1): p. 67-83., https://www.ncbi.nlm.nih.gov/pubmed/27903827

70. Zick, S. M., Sen, A., Wyatt, G. K., Murphy, S. L., Arnedt, J. T., Harris, R. E., Investigation of 2 Types of Self-administered Acupressure for Persistent Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Clinical Trial, JAMA Oncol, 2016. 2(11): p. 1470-1476., https://www.ncbi.nlm.nih.gov/pubmed/27388752

71. Roscoe, J. A., Matteson, S. E., Morrow, G. R., Hickok, J. T., Bushunow, P., Griggs, J., et.al. Acustimulation wrist bands are not effective for the control of chemotherapy-induced nausea in women with breast cancer, J Pain Symptom Manage, 2005. 29(4): p. 376-84., https://www.ncbi.nlm.nih.gov/pubmed/15857741

72. Roscoe, J. A., Morrow, G. R., Hickok, J. T., Bushunow, P., Pierce, H. I., Flynn, P. J., et.al. The efficacy of acupressure and acustimulation wrist bands for the relief of chemotherapy-induced nausea and vomiting. A University of Rochester Cancer Center Community Clinical Oncology Program multicenter study, J Pain Symptom Manage, 2003. 26(2): p. 731-42., https://www.ncbi.nlm.nih.gov/pubmed/12906958

73. Sharif Nia, H., Pahlevan Sharif, S., Yaghoobzadeh, A., Yeoh, K. K., Goudarzian, A. H., Soleimani, M. A., et.al. Effect of acupressure on pain in Iranian leukemia patients: A randomized controlled trial study, Int J Nurs Pract, 2017. 23(2):, https://www.ncbi.nlm.nih.gov/pubmed/28058748

74. Kroz, M., Fink, M., Reif, M., Grobbecker, S., Zerm, R., Quetz, M., et.al. Multimodal therapy concept and aerobic training in breast cancer patients with chronic cancer-related fatigue, Integr Cancer Ther, 2013. 12(4): p. 301-11., https://www.ncbi.nlm.nih.gov/pubmed/23264335

75. Kroz, M., Reif, M., Glinz, A., Berger, B., Nikolaou, A., Zerm, R., et.al. Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancer-related fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design, BMC Cancer, 2017. 17(1): p. 166., https://www.ncbi.nlm.nih.gov/pubmed/28253845

76. Carlsson, M., Arman, M., Backman, M., Flatters, U., Hatschek, T., Hamrin, E., Evaluation of quality of life/life satisfaction in women with breast cancer in complementary and conventional care, Acta Oncol, 2004. 43(1): p. 27-34., https://www.ncbi.nlm.nih.gov/pubmed/15068317

77. Carlsson, M., Arman, M., Backman, M., Flatters, U., Hatschek, T., Hamrin, E., A Five-year Follow-up of Quality of Life in Women with Breast Cancer in Anthroposophic and Conventional Care, Evid Based Complement Alternat Med, 2006. 3(4): p. 523-31., https://www.ncbi.nlm.nih.gov/pubmed/17173117

78. Carlsson, M., Arman, M., Backman, M., Hamrin, E., Perceived quality of life and coping for Swedish women with breast cancer who choose complementary medicine, Cancer Nurs, 2001. 24(5): p. 395-401., https://www.ncbi.nlm.nih.gov/pubmed/11605710

79. Poier, D., Bussing, A., Rodrigues Recchia, D., Beerenbrock, Y., Reif, M., Nikolaou, A., et.al. Influence of a Multimodal and Multimodal-Aerobic Therapy Concept on Health-Related Quality of Life in Breast Cancer Survivors, Integr Cancer Ther, 2019. 18: p. 1534735418820447., https://www.ncbi.nlm.nih.gov/pubmed/30584782

80. Heusser, P., Braun, S. B., Bertschy, M., Burkhard, R., Ziegler, R., Helwig, S., et.al. Palliative in-patient cancer treatment in an anthroposophic hospital: II. Quality of life during and after stationary treatment, and subjective treatment benefits, Forsch Komplementmed, 2006. 13(3): p. 156-66., https://www.ncbi.nlm.nih.gov/pubmed/16868361

81. Bar-Sela, G., Atid, L., Danos, S., Gabay, N., Epelbaum, R., Art therapy improved depression and influenced fatigue levels in cancer patients on chemotherapy, Psychooncology, 2007. 16(11): p. 980-4., https://www.ncbi.nlm.nih.gov/pubmed/17351987

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783. Banerjee, S., Kambhampati, S., Haque, I., Banerjee, S. K., Pomegranate sensitizes Tamoxifen action in ER-alpha positive breast cancer cells, J Cell Commun Signal, 2011. 5(4): p. 317-24., https://www.ncbi.nlm.nih.gov/pubmed/21706446

784. Auerbach, L., Rakus, J., Bauer, C., Gerner, C., Ullmann, R., Wimmer, H., et.al. Pomegranate seed oil in women with menopausal symptoms: a prospective randomized, placebo-controlled, double-blinded trial, Menopause, 2012. 19(4): p. 426-32., https://www.ncbi.nlm.nih.gov/pubmed/22240636

785. Sorokin, A. V., Duncan, B., Panetta, R., Thompson, P. D., Rhabdomyolysis associated with pomegranate juice consumption, Am J Cardiol, 2006. 98(5): p. 705-6., https://www.ncbi.nlm.nih.gov/pubmed/16923466

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788. Mirmiran, P., Fazeli, M. R., Asghari, G., Shafiee, A., Azizi, F., Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial, Br J Nutr, 2010. 104(3): p. 402-6., https://www.ncbi.nlm.nih.gov/pubmed/20334708

789. Forest, C. P., Padma-Nathan, H., Liker, H. R., Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study, Int J Impot Res, 2007. 19(6): p. 564-7., https://www.ncbi.nlm.nih.gov/pubmed/17568759

790. Sumner, M. D., Elliott-Eller, M., Weidner, G., Daubenmier, J. J., Chew, M. H., Marlin, R., et.al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease, Am J Cardiol, 2005. 96(6): p. 810-4., https://www.ncbi.nlm.nih.gov/pubmed/16169367

791. Cerdá, Begoña, Soto, C, Albaladejo, MD, Martinez, P, Sanchez-Gascon, F, Tomás-Barberán, Francisco, et.al. Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial, European journal of clinical nutrition, 2006. 60(2): p. 245-253., https://pubmed.ncbi.nlm.nih.gov/16278692/

792. Gbinigie, Oghenekome A, Onakpoya, Igho J, Spencer, Elizabeth A, Evidence for the effectiveness of pomegranate supplementation for blood pressure management is weak: A systematic review of randomized clinical trials, Nutrition Research, 2017. 46: p. 38-48., https://pubmed.ncbi.nlm.nih.gov/29173650/

793. Freedland, Stephen J, Carducci, Michael, Kroeger, Nils, Partin, Alan, Rao, Jian-yu, Jin, Yusheng, et.al. A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy, Cancer prevention research, 2013. 6(10): p. 1120-1127., https://pubmed.ncbi.nlm.nih.gov/23985577/

794. Pantuck, A. J., Pettaway, C. A., Dreicer, R., Corman, J., Katz, A., Ho, A., et.al. A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer, Prostate Cancer Prostatic Dis, 2015. 18(3): p. 242-8., https://www.ncbi.nlm.nih.gov/pubmed/26169045

795. Thomas, R., Williams, M., Sharma, H., Chaudry, A., Bellamy, P., A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study, Prostate Cancer Prostatic Dis, 2014. 17(2): p. 180-6., https://www.ncbi.nlm.nih.gov/pubmed/24614693

796. Stenner-Liewen, Frank, Liewen, Heike, Cathomas, Richard, Renner, Christoph, Petrausch, Ulf, Sulser, Tullio, et.al. Daily pomegranate intake has no impact on PSA levels in patients with advanced prostate cancer-results of a phase IIb randomized controlled trial, Journal of Cancer, 2013. 4(7): p. 597., https://pubmed.ncbi.nlm.nih.gov/24069070/

797. Kapoor, R., Ronnenberg, A., Puleo, E., Chatterton, R. T., Jr., Dorgan, J. F., Seeram, N. P., et.al. Effects of Pomegranate Juice on Hormonal Biomarkers of Breast Cancer Risk, Nutr Cancer, 2015. 67(7): p. 1113-9., https://www.ncbi.nlm.nih.gov/pubmed/26327495

798. Nuñez-Sánchez, María A, González-Sarrías, Antonio, García-Villalba, Rocío, Monedero-Saiz, Tamara, García-Talavera, Noelia V, Gómez-Sánchez, María B, et.al. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial, The Journal of nutritional biochemistry, 2017. 42: p. 126-133., https://pubmed.ncbi.nlm.nih.gov/28183047/

799. González-Sarrías, A, Núñez-Sánchez, MA, Ávila-Gálvez, MA, Monedero-Saiz, T, Rodríguez-Gil, FJ, Martínez-Díaz, Francisco, et.al. Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial, Food & function, 2018. 9(5): p. 2617-2622., https://pubmed.ncbi.nlm.nih.gov/29770393/

800. Gil, M. I., Tomas-Barberan, F. A., Hess-Pierce, B., Holcroft, D. M., Kader, A. A., Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing, J Agric Food Chem, 2000. 48(10): p. 4581-9., https://www.ncbi.nlm.nih.gov/pubmed/11052704

801. Cerdá, Begoña, Espín, Juan Carlos, Parra, Soledad, Martínez, Pedro, Tomás-Barberán, Francisco A, The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy–6H–dibenzopyran–6–one derivatives by the colonic microflora of healthy humans, European journal of nutrition, 2004. 43(4): p. 205-220., https://pubmed.ncbi.nlm.nih.gov/15309440/

802. Yildirim, N. C., Kandemir, F. M., Ceribasi, S., Ozkaraca, M., Benzer, F., Pomegranate seed extract attenuates chemotherapy-induced liver damage in an experimental model of rabbits, Cell Mol Biol (Noisy-le-grand), 2013. 59 Suppl(Suppl): p. OL1842-7., https://www.ncbi.nlm.nih.gov/pubmed/23374454

803. Hidaka, M., Okumura, M., Fujita, K., Ogikubo, T., Yamasaki, K., Iwakiri, T., et.al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats, Drug Metab Dispos, 2005. 33(5): p. 644-8., https://www.ncbi.nlm.nih.gov/pubmed/15673597

804. Nagata, M., Hidaka, M., Sekiya, H., Kawano, Y., Yamasaki, K., Okumura, M., et.al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats, Drug Metab Dispos, 2007. 35(2): p. 302-5., https://www.ncbi.nlm.nih.gov/pubmed/17132763

805. Summers, Kelly M, Potential Drug–Food Interactions with Pomegranate Juice, Annals of Pharmacotherapy, 2006. 40(7-8): p. 1472-1473., https://pubmed.ncbi.nlm.nih.gov/16804094/

806. Farkas, Dora, Oleson, Lauren E, Zhao, Yanli, Harmatz, Jerold S, Zinny, Miguel A, Court, Michael H, et.al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450‐3A activity: comparison with grapefruit juice, The Journal of Clinical Pharmacology, 2007. 47(3): p. 286-294., https://pubmed.ncbi.nlm.nih.gov/17322140/

807. Hanley, Michael J, Masse, Gina, Harmatz, Jerold S, Court, Michael H, Greenblatt, David J, Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results, Clinical Pharmacology & Therapeutics, 2012. 92(5): p. 651-657., https://pubmed.ncbi.nlm.nih.gov/23047652/

808. Misaka, S., Nakamura, R., Uchida, S., Takeuchi, K., Takahashi, N., Inui, N., et.al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers, Clin Ther, 2011. 33(2): p. 246-52., https://www.ncbi.nlm.nih.gov/pubmed/21497708

809. Park, Soo-Jin, Yeo, Chang-Woo, Shim, Eon-Jeong, Kim, Hyunmi, Liu, Kwang-Hyeon, Shin, Jae-Gook, et.al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects, European journal of drug metabolism and pharmacokinetics, 2016. 41(4): p. 339-344., https://pubmed.ncbi.nlm.nih.gov/25720525/

810. van Die, M. D., Bone, K. M., Emery, J., Williams, S. G., Pirotta, M. V., Paller, C. J., Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials, BJU Int, 2016. 117 Suppl 4: p. 17-34., https://www.ncbi.nlm.nih.gov/pubmed/26898239

811. Paller, C. J., Pantuck, A., Carducci, M. A., A review of pomegranate in prostate cancer, Prostate Cancer Prostatic Dis, 2017. 20(3): p. 265-270., https://www.ncbi.nlm.nih.gov/pubmed/28440320

812. Komperda, Kathy E, Potential interaction between pomegranate juice and warfarin, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2009. 29(8): p. 1002-1006., https://pubmed.ncbi.nlm.nih.gov/19637955/

813. Awad, R., Mallah, E., Khawaja, B. A., Dayyih, W. A., El-Hajji, F., Matalka, K. Z., et.al. Pomegranate and licorice juices modulate metformin pharmacokinetics in rats, Neuro Endocrinol Lett, 2016. 37(3): p. 202-206., https://www.ncbi.nlm.nih.gov/pubmed/27618606

814. da Costa Miranda, V., Trufelli, D. C., Santos, J., Campos, M. P., Nobuo, M., da Costa Miranda, M., et.al. Effectiveness of guarana (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study, J Altern Complement Med, 2009. 15(4): p. 431-3., https://www.ncbi.nlm.nih.gov/pubmed/19388866

815. de Oliveira Campos, M. P., Riechelmann, R., Martins, L. C., Hassan, B. J., Casa, F. B., Del Giglio, A., Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy, J Altern Complement Med, 2011. 17(6): p. 505-12., https://www.ncbi.nlm.nih.gov/pubmed/21612429

816. del Giglio, A. B., Cubero Dde, I., Lerner, T. G., Guariento, R. T., de Azevedo, R. G., Paiva, H., et.al. Purified dry extract of Paullinia cupana (guarana) (PC-18) for chemotherapy-related fatigue in patients with solid tumors: an early discontinuation study, J Diet Suppl, 2013. 10(4): p. 325-34., https://www.ncbi.nlm.nih.gov/pubmed/24237188

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825. Tangen, J. M., Tierens, A., Caers, J., Binsfeld, M., Olstad, O. K., Troseid, A. M., et.al. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study, Biomed Res Int, 2015. 2015: p. 718539., https://www.ncbi.nlm.nih.gov/pubmed/25664323

826. Ahn, W. S., Kim, D. J., Chae, G. T., Lee, J. M., Bae, S. M., Sin, J. I., et.al. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy, Int J Gynecol Cancer, 2004. 14(4): p. 589-94., https://www.ncbi.nlm.nih.gov/pubmed/15304151

827. Ulbricht, C., Weissner, W., Basch, E., Giese, N., Hammerness, P., Rusie-Seamon, E., et.al. Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration, J Soc Integr Oncol, 2009. 7(2): p. 66-72., https://www.ncbi.nlm.nih.gov/pubmed/19476741

828. Chaiyasut, C., Sivamaruthi, B.S., Anti-hyperglycemic property of Hericium erinaceus – A mini review, Asian Pacific Journal of Tropical Biomedicine, 2017. 7(11): p. 1036-1040., https://doi.org/10.1016/j.apjtb.2017.09.024

829. Zeng, X., Ling, H., Yang, J., Chen, J., Guo, S., Proteome analysis provides insight into the regulation of bioactive metabolites in Hericium erinaceus, Gene, 2018. 666: p. 108-115., https://www.ncbi.nlm.nih.gov/pubmed/29738838

830. Saitsu, Y., Nishide, A., Kikushima, K., Shimizu, K., Ohnuki, K., Improvement of cognitive functions by oral intake of Hericium erinaceus, Biomed Res, 2019. 40(4): p. 125-131., https://www.ncbi.nlm.nih.gov/pubmed/31413233

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902. Von Hagens, C., Loewe-Mesch, A., Kuehn, J., Abel, U., Gerhard, I., Prospektive kontrollierte nicht randomisierte Machbarkeits-Studie zu einer postoperativen simultanen Mistel-/Chemotherapie bei Patientinnen mit Mammakarzinom—Ergebnisse zu Rekrutier-und Randomisierbarkeit, Immunparametern, Lebensqualität und Verträglichkeit. Fortschritte in der Misteltherapie. Aktueller Stand der Forschung und klinischen Anwendung.KVC Verlag, 2005. 567-578:, https://pubmed.ncbi.nlm.nih.gov/18955332/

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988. Fallon, Marie T., Albert Lux, Eberhard, McQuade, Robert, Rossetti, Sandro, Sanchez, Raymond, Sun, Wei, et.al. Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies, British journal of pain, 2017. 11(3): p. 119-133., https://pubmed.ncbi.nlm.nih.gov/28785408/

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991. Cote, Mathieu, Trudel, Mathieu, Wang, Changshu, Fortin, Andre, Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial, The Annals of otology, rhinology, and laryngology, 2016. 125(4): p. 317-24., https://pubmed.ncbi.nlm.nih.gov/26503964/

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